This clinical casebook provides a comprehensive yet concise state-of-the-art review of gluten-associated disorders. Presented in a case-based format, the casebook reviews the overall management of celiac disease (from seronegative through classical to refractory disease) as well as non-celiac gluten/wheat sensitivity, with an emphasis on gastrointestinal and extra-intestinal manifestations of these disorders. Specific topics presented in these cases include, for instance, dermatitis herpetiformis, celiac disease and the liver, non-responsive celiac disease, celiac crisis, overlap with functional gastrointestinal disorders, and fructan intolerance. Two chapters written by expert dieticians share their experience in managing celiac disease and gluten/wheat sensitivity. Written by international experts in the field, Diagnosis and Management of Gluten-Associated Disorders: A Clinical Casebook is a valuable resource for both adult and pediatric gastroenterologists, hepatologists, primary care physicians, dermatologists, registered dieticians, trainees, and researchers interested in gluten-associated disorders.
Author(s): Guy A. Weiss
Publisher: Springer
Year: 2020
Language: English
Pages: 225
City: Cham
Preface
Contents
Contributors
Abbreviations
Chapter 1: From Classical to Non-classical Celiac Disease
Case Presentation
Diagnosis
Screening
Histology
Management
Monitoring
Case Outcome
References
Chapter 2: Dermatitis Herpetiformis
Case Presentation
Diagnosis
Management
Case Outcome
References
Chapter 3: Celiac Disease and the Liver
Case Presentation
Diagnosis and Management
Case Outcome
References
Chapter 4: Pediatric Celiac Disease
Case Presentation
Diagnosis and Management
Celiac Disease in Children, Not Just a Gastrointestinal Disorder
What Causes Celiac Disease?
A Careful Diagnosis
Screening Children/Siblings of Celiac Patients
Treatment and Follow-Up
Case Outcome
References
Chapter 5: Celiac Disease and Women’s Health
Case Presentation
Diagnosis and Management
Outcome
References
Chapter 6: Gluten Challenge in Gluten-Associated Disorders
Case Presentation
Diagnosis and Management
Indications for Gluten Challenge in Different Populations
Principles of Gluten Challenge
Setting
Blinding
Gluten formulation
Dose and Duration
Endpoints of Gluten Challenge
Symptomatic Endpoints of Gluten Challenge
Celiac Disease
Non-celiac Gluten Sensitivity
Serologic Tests Following a Gluten Challenge
Celiac Disease
NCGS
Evaluation of Small Intestinal Mucosa Following a Gluten Challenge
Celiac Disease
NCGS
Emerging Biomarkers
Lactulose-to-Mannitol (LAMA) Ratio
Serum Intestinal-Fatty Acid Binding Protein (Serum I-FABP)
Gluten-Reactive T-Cells
HLA-DQ Gluten Tetramer
Intraepithelial Lymphocyte Immunophenotyping
Potential NCGS Biomarkers
Case Outcome
References
Chapter 7: Seronegative Celiac Disease
Case Presentation
Diagnosis and Management
Pathogenesis
Diagnosis
Clinical Course and Natural History
Treatment
Case Outcome
Bibliography
Chapter 8: Non-Responsive Celiac Disease
Case Presentation
Diagnosis
Management
Case Outcome
References
Chapter 9: Type I Refractory Celiac Disease
Case Presentation
Diagnosis
Management
Case Outcome
References
Chapter 10: Type II Refractory Celiac Disease
Case Presentation
Diagnosis
Management
Case Outcome
References
Chapter 11: Enteropathy-Associated T-Cell Lymphoma
Case Presentation
Diagnosis
Clinical Presentation and Risk Factors
Pathologic Features
Staging
Management
Case Outcome
References
Chapter 12: Celiac Crisis
Case Presentation
Diagnosis and Management
Review of the Literature
Case Outcome
References
Chapter 13: The Role of Capsule Endoscopy in Celiac Disease
Introduction
Capsule Endoscopy in Patients with Suspected Celiac Disease
Capsule Endoscopy in Patients with Non-Responsive Celiac Disease
Future Directions
Conclusion
References
Chapter 14: Between Functional Gastrointestinal Disorders and Celiac Disease
Case Presentation
Diagnosis
Management
Case Outcome
References
Chapter 15: The Dietitian Role in Celiac Disease
Case Presentation
Diagnosis and Management
Nutrition-Related Diagnosis
Medications and Supplements
Nonconsumable Sources of Gluten
Reading Food Labels
Cross-Contact at Home
Dining Out
Oat Intake
Screening for Micronutrient Deficiencies
Recommendations Based on Dietary Assessment
Case Outcome
References
Chapter 16: Non-Celiac Gluten Sensitivity
Case Presentation
Diagnosis
Management
Case Outcome
References
Chapter 17: The Dietitian Role in Non-Celiac Gluten Sensitivity
Case Presentation
Diagnosis and Management
Case Outcome
References
Chapter 18: Fructan Intolerance
Case Presentation
Diagnosis
Management
Case Outcome
References
Index