This book will assemble the views of many of the world's experts in the field of viruses and diabetes. It will look critically at some unanswered questions, in the field. Among these, How do viruses destroy or modify the pancreatic islet? Which viruses are involved? What is the role of virus-induced cytokines> Could vaccines prevent virus-induced diabetes? Until recent technological advances, progress in the understanding of the relationship between viruses and diabetes has been hampered. New technologies are helping shed new light on these mysteries. This will be the first comprehensive volume on this topic.
Author(s): Keith W. Taylor M.B.B.S., Ph.D., F.R.C.P. (auth.), Keith Taylor, Heikki Hyöty, Antonio Toniolo, Arie J. Zuckerman (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2013
Language: English
Pages: 373
Tags: Virology; Infectious Diseases; Immunology; Pharmacology/Toxicology
Front Matter....Pages i-xxi
Front Matter....Pages 1-1
Historical Background: Earlier Studies on the Connexion Between Viruses and Diabetes....Pages 3-6
Viruses and Autoimmune Diabetes: A History....Pages 7-12
Genetics of Type 1 Diabetes....Pages 13-24
Non-Genetic Factors in the Pathogenesis of Type 1 Diabetes....Pages 25-34
Front Matter....Pages 35-35
Encephalomyocarditis Virus....Pages 37-48
Enteroviruses in the Mouse Model of Type 1 Diabetes....Pages 49-56
Viruses and Autoimmune Diabetes in Rats....Pages 57-70
Reovirus....Pages 71-80
Ljungan Virus and Diabetes....Pages 81-86
Virus-Related Diabetes in Cattle....Pages 87-97
Front Matter....Pages 99-99
Epidemiology of Viruses in Type 1 Diabetes: Seasonal Incidence, Family Studies, Clustering....Pages 101-107
Molecular Biology and Classification of Enteroviruses....Pages 109-115
Laboratory Diagnosis of Enterovirus Infection: Optimal Methods for Studies of Diabetes....Pages 117-128
Enterovirus Immunity and the “Hygiene Hypothesis”....Pages 129-141
Enteroviruses in Blood....Pages 143-155
Coxsackieviruses and Insulitis....Pages 157-166
Viruses in the Human Pancreas....Pages 167-175
Rotavirus and Type 1 Diabetes....Pages 177-186
Viruses, Diabetes, and Autoimmunity: Studies of Subjects at Genetic Risk for Type 1 Diabetes....Pages 187-194
Type 1 Diabetes in the Tropics: A Link with Enterovirus Infections....Pages 195-205
Front Matter....Pages 99-99
Diabetes and Viruses in Australia and the Asia-Pacific Region....Pages 207-217
Fulminant Type 1 Diabetes in Japan....Pages 219-229
Front Matter....Pages 231-231
Defining Causal Relationships Between Viral Infections and Human Diabetes....Pages 233-243
The JDRF Network for the Pancreatic Organ Donor with Diabetes (nPOD): A novel Resource and Study Approach in Type 1 Diabetes Research....Pages 245-255
Front Matter....Pages 257-257
Virus-Induced Models for Type 1 Diabetes in Mice....Pages 259-269
The Role of T Lymphocytes in the Pathogenesis of Autoimmune Type 1 Diabetes: Implications for Potential Virus-Mediated Pathways....Pages 271-286
Innate Immune Responses to Viruses Inducing Diabetes....Pages 287-297
Enterovirus Infection of Cultured Human Pancreatic Islets....Pages 299-312
Innate Immunity of Human Pancreatic Islets Infected with Different Enterovirus Types....Pages 313-323
Antibody-Dependent Enhancement of Coxsackievirus-B Infection: Role in the Pathogenesis of Type 1 Diabetes....Pages 325-335
Front Matter....Pages 337-337
Speculation on Prevention of Type 1 Diabetes....Pages 339-347
Viruses as Major Environmental Factors in the Induction of Diabetes....Pages 349-355
Reflections on Viruses and Diabetes Mellitus....Pages 357-363
Back Matter....Pages 365-373
