Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more. Approved by the God of Education.
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The most effective strategies for managing every type of cancer by stage of presentation.
Balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist.
Important related topics such as cancer screening and prevention, palliative care, supportive oncology, and quality of life issues.
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Author(s): Vincent T. DeVita, Steven A. Rosenberg, Theodore S. Lawrence
Series: Eğitim Tanrısı
Edition: 11th
Publisher: LWW
Year: 2018
Language: English
Commentary: CONVERTED PDF
Pages: 4361
City: Ankara
Tags: Cancer; Oncology
1. Cover......Page 2
2. Title Page......Page 3
3. Editors......Page 4
4. Copyright......Page 7
5. Contributing Authors......Page 8
6. PREFACE......Page 53
7. ACKNOWLEDGMENT......Page 54
8. CONTENTS......Page 55
9. Part I: Molecular Biology of Cancer......Page 90
10. 1 The Cancer Genome......Page 91
11. 2 Molecular Methods in Cancer......Page 128
12. 3 Hallmarks of Cancer: An Organizing Principle for Cancer Medicine......Page 159
13. 4 Microbiome and Cancer......Page 197
14. 5 Cancer Susceptibility Syndromes......Page 216
15. Part II: Etiology and Epidemiology of Cancer......Page 236
16. Section 1 Etiology of Cancer......Page 237
17. 6 Tobacco......Page 238
18. 7 Oncogenic Viruses......Page 252
19. 8 Inflammation......Page 277
20. 9 Chemical Factors......Page 288
21. 10 Physical Factors......Page 297
22. 11 Dietary Factors......Page 311
23. 12 Obesity and Physical Activity......Page 331
24. Section 2 Epidemiology of Cancer......Page 342
25. 13 Epidemiologic Methods......Page 343
26. 14 Global Cancer Incidence and Mortality......Page 357
27. Part III: Cancer Therapeutics......Page 393
28. 15 Precision Medicine in Oncology......Page 394
29. 16 Essentials of Radiation Therapy......Page 411
30. 17 Cancer Immunotherapy......Page 456
31. 18 Pharmacokinetics and Pharmacodynamics of Anticancer Drugs......Page 478
32. 19 Pharmacogenomics......Page 492
33. 20 Alkylating Agents......Page 503
34. 21 Platinum Analogs......Page 520
35. 22 Antimetabolites......Page 535
36. 23 Topoisomerase-Interacting Agents......Page 551
37. 24 Antimicrotubule Agents......Page 571
38. 25 Kinase Inhibitors as Anticancer Drugs......Page 586
39. 26 Histone Deacetylase Inhibitors and Demethylating Agents......Page 610
40. 27 Proteasome Inhibitors......Page 624
41. 28 Poly(ADP-Ribose) Polymerase Inhibitors for Tumors with Defects in DNA Repair......Page 643
42. 29 Miscellaneous Chemotherapeutic Agents......Page 651
43. 30 Hormonal Agents......Page 667
44. 31 Monoclonal Antibodies......Page 686
45. 32 Immunotherapy Agents......Page 705
46. Part IV: Cancer Prevention and Screening......Page 732
47. 33 Tobacco Use and the Cancer Patient......Page 733
48. 34 Role of Surgery in Cancer Prevention......Page 755
49. 35 Cancer Risk–Reducing Agents......Page 785
50. 36 Prophylactic Cancer Vaccines......Page 831
51. 37 Cancer Screening......Page 848
52. 38 Genetic Counseling......Page 878
53. Part V: Practice of Oncology......Page 902
54. 39 Design and Analysis of Clinical Trials......Page 903
55. 40 Assessment of Clinical Response......Page 928
56. 41 Vascular Access......Page 947
57. 42 Endoscopic and Robotic Surgery......Page 959
58. 43 Tumor Biomarkers......Page 973
59. Section 1 Cancer of the Head and Neck......Page 986
60. 44 The Molecular Biology of Head and Neck Cancers......Page 987
61. 45 Cancer of the Head and Neck......Page 999
62. Differential Diagnosis and Staging......Page 1045
63. 46 Rehabilitation After Treatment of Head and Neck Cancer......Page 1098
64. Section 2 Cancer of the Thoracic Cavity......Page 1114
65. 47 The Molecular Biology of Lung Cancer......Page 1115
66. 48 Non–small-cell Lung Cancer......Page 1135
67. Stage IV (M1)......Page 1186
68. 49 Small Cell and Neuroendocrine Tumors of the Lung......Page 1223
69. 50 Neoplasms of the Mediastinum......Page 1274
70. Section 3 Cancers of the Gastrointestinal Tract......Page 1296
71. 51 Molecular Biology of the Esophagus and Stomach......Page 1297
72. 52 Cancer of the Esophagus......Page 1307
73. Treatment of Localized Disease (.T2, Nany, M0)......Page 1352
74. 53 Cancer of the Stomach......Page 1386
75. Gastric Cancer in the Elderly......Page 1431
76. 54 The Molecular Biology of Pancreas Cancer......Page 1447
77. 55 Cancer of the Pancreas......Page 1460
78. Conclusion......Page 1500
79. 56 Molecular Biology of Liver Cancer......Page 1515
80. 57 Cancer of the Liver......Page 1528
81. 58 Cancer of the Biliary Tree......Page 1564
82. 59 Small Bowel Cancer......Page 1595
83. 60 Gastrointestinal Stromal Tumor......Page 1614
84. 61 Molecular Biology of Colorectal Cancer......Page 1634
85. 62 Cancer of the Colon......Page 1652
86. Oxaliplatin......Page 1704
87. 63 Cancer of the Rectum......Page 1742
88. 64 Cancer of the Anal Region......Page 1787
89. 65 Molecular Biology of Kidney Cancer......Page 1816
90. Section 4 Cancers of the Genitourinary System......Page 1826
91. 66 Cancer of the Kidney......Page 1827
92. 67 Molecular Biology of Bladder Cancer......Page 1864
93. 68 Cancer of the Bladder, Ureter, and Renal Pelvis......Page 1878
94. 69 The Molecular Biology of Prostate Cancer......Page 1924
95. 70 Cancer of the Prostate......Page 1942
96. Radiotherapy for Localized Prostate Cancer......Page 1978
97. 71 Cancer of the Urethra and Penis......Page 2027
98. 72 Cancer of the Testis......Page 2042
99. Section 5 Gynecologic Cancers......Page 2074
100. 73 Molecular Biology of Gynecologic Cancers......Page 2075
101. 74 Cancer of the Cervix, Vagina, and Vulva......Page 2090
102. Treatment of Metastatic Disease......Page 2145
103. 75 Cancer of the Uterine Body......Page 2159
104. 76 Gestational Trophoblastic Neoplasia......Page 2187
105. 77 Ovarian Cancer......Page 2196
106. Section 6 Cancer of the Breast......Page 2242
107. 78 Molecular Biology of Breast Cancer......Page 2243
108. 79 Malignant Tumors of the Breast......Page 2261
109. Mastectomy......Page 2296
110. Section 7 Cancer of the Endocrine System......Page 2341
111. 80 Molecular Biology of Endocrine Tumors......Page 2342
112. 81 Thyroid Tumors......Page 2358
113. 82 Parathyroid Tumors......Page 2378
114. 83 Adrenal Tumors......Page 2388
115. 84 Pancreatic Neuroendocrine Tumors......Page 2403
116. 85 Carcinoid Tumors and the Carcinoid Syndrome......Page 2429
117. 86 Multiple Endocrine Neoplasia......Page 2446
118. Section 8 Sarcomas of Soft Tissue and Bone......Page 2458
119. 87 Molecular Biology of Sarcomas......Page 2459
120. 88 Soft Tissue Sarcoma......Page 2488
121. Serious Complications of Primary Treatment......Page 2537
122. 89 Sarcomas of Bone......Page 2573
123. Section 9 Cancers of the Skin......Page 2613
124. 90 Cancer of the Skin......Page 2614
125. 91 Molecular Biology of Cutaneous Melanoma......Page 2659
126. 92 Cutaneous Melanoma......Page 2674
127. Treatment of Unresectable Metastatic (Stage IV) Melanoma......Page 2729
128. Section 10 Neoplasms of the Central Nervous System......Page 2758
129. 93 Molecular Biology of Central Nervous System Tumors......Page 2759
130. 94 Neoplasms of the Central Nervous System......Page 2770
131. Chemotherapy......Page 2814
132. Section 11 Cancers in Adolescents and Young Adults......Page 2853
133. 95 Adolescents and Young Adults with Cancer......Page 2854
134. 96 Molecular Biology of Lymphoma......Page 2879
135. Section 12 Lymphomas in Adults......Page 2908
136. 97 Hodgkin Lymphoma......Page 2909
137. 98 Non-Hodgkin Lymphoma......Page 2948
138. HIV-associated Non-Hodgkin Lymphoma......Page 2995
139. 99 Cutaneous Lymphomas......Page 3012
140. 100 Primary Central Nervous System Lymphoma......Page 3035
141. Section 13 Leukemias and Plasma Cell Tumors......Page 3047
142. 101 Molecular Biology of Acute Leukemias......Page 3048
143. 102 Management of Acute Leukemias......Page 3070
144. 103 Molecular Biology of Chronic Leukemias......Page 3108
145. 104 Chronic Myeloid Leukemia......Page 3125
146. 105 Chronic Lymphocytic Leukemias......Page 3146
147. 106 Myelodysplastic Syndromes......Page 3176
148. 107 Plasma Cell Neoplasms......Page 3202
149. POEMS Syndrome......Page 3248
150. Section 14 Other Cancers......Page 3262
151. 108 Cancer of Unknown Primary......Page 3263
152. 109 Benign and Malignant Mesothelioma......Page 3274
153. 110 Peritoneal Metastases and Peritoneal Mesothelioma......Page 3317
154. 111 Intraocular Melanoma......Page 3335
155. Section 15 Oncologic Emergencies......Page 3353
156. 112 Superior Vena Cava Syndrome......Page 3354
157. 113 Increased Intracranial Pressure......Page 3364
158. 114 Spinal Cord Compression......Page 3374
159. 115 Metabolic Emergencies......Page 3384
160. Section 16 Treatment of Metastatic Cancer......Page 3393
161. 116 Metastatic Cancer to the Brain......Page 3394
162. 117 Metastatic Cancer to the Lung......Page 3415
163. 118 Metastatic Cancer to the Liver......Page 3434
164. 119 Metastatic Cancer to the Bone......Page 3456
165. 120 Malignant Pleural and Pericardial Effusions......Page 3479
166. 121 Malignant Ascites......Page 3493
167. 122 Paraneoplastic Syndromes......Page 3504
168. Section 17 Stem Cell Transplantation......Page 3521
169. 123 Autologous Hematopoietic Cell Transplantation......Page 3522
170. 124 Allogeneic Stem Cell Transplantation......Page 3540
171. Section 18 Management of Adverse Effects of Treatment......Page 3569
172. 125 Infections in the Cancer Patient......Page 3570
173. 126 Neutropenia and Thrombocytopenia......Page 3624
174. 127 Nausea and Vomiting......Page 3638
175. 128 Diarrhea and Constipation......Page 3653
176. 129 Oral Complications......Page 3669
177. 130 Pulmonary Toxicity......Page 3694
178. 131 Cardiac Toxicity......Page 3711
179. 132 Hair Loss and Other Hair Changes......Page 3726
180. 133 Gonadal Dysfunction......Page 3734
181. 134 Fatigue......Page 3760
182. 135 Second Cancers......Page 3772
183. 136 Neurocognitive Effects......Page 3804
184. 137 Cancer Survivorship......Page 3815
185. Part VI: Palliative and Alternative Care......Page 3828
186. Section 1 Supportive Care and Quality of Life......Page 3829
187. 138 Management of Cancer Pain......Page 3830
188. 139 Nutrition Support......Page 3868
189. 140 Sexual Problems......Page 3881
190. 141 Psychological Issues......Page 3898
191. 142 Communicating News to the Cancer Patient......Page 3914
192. 143 Specialized Care of the Terminally Ill......Page 3919
193. 144 Rehabilitation of the Cancer Patient......Page 3931
194. Section 2 Complementary, Alternative, and Integrative Therapies......Page 3966
195. 145 Complementary, Alternative, and Integrative Therapies in Cancer Care......Page 3967
196. INDEX......Page 3993
197. INDEX......Page 4037
198. INDEX......Page 4083
199. INDEX......Page 4122
200. INDEX......Page 4169
201. INDEX......Page 4217
202. INDEX......Page 4240
203. INDEX......Page 4278
204. INDEX......Page 4326
