This new volume in the Foundations in Diagnostic Pathology Series packs all of today's most essential dermatopathology know-how into a compact, high-yield format! Its pragmatic, well-organized approach, abundant full-color illustrations, and at-a-glance tables make the information you need easy to access. Over 1,100 full-color photographs capture the appearance of a full range of skin lesions. And, Expert Consult functionality gives you easy access to the full text online as well as all of the book's images for enhanced visual guidance. . Features online access to the full text and all the illustrations from the book, with links to PubMed, for easy referencing at expertconsult.com. . Covers both neoplastic and non-neoplastic disorders of the skin. . Provides detailed discussions of metabolic, systemic, allergic, infectious, and inflammatory skin diseases as well as cutaneous neoplasms giving you well-rounded, comprehensive coverage. . Offers over 1,100 full-color, high-quality photographs that demonstrate the key features of a wide variety of pathologic lesions offering enhanced diagnostic guidance. . Employs a consistent, user-friendly organization throughout to present each pathologic entity's gross and microscopic features, prognostic and therapeutic considerations, ancillary studies, and differential diagnoses. . Presents information in boxes and tables for at-a-glance reference.The Foundations in Diagnostic Pathology Series answers the call for fresh, affordable, and easy-to-use guidance. Each region-specific volume provides all of the most essential information on the pathologic entities encountered in practice. Series Editor: John R. Goldblum, MD, FACP, FASCP, FACGWith 13 additional contributing experts.
Author(s): Klaus J. Busam MD
Edition: Har/Psc
Year: 2009
Language: English
Pages: 690
Copyright......Page 2
Dedication......Page 3
Foreword......Page 4
Preface......Page 5
Contributors......Page 6
Melanocytes......Page 9
Langerhans Cells......Page 10
Dermis......Page 11
Eccrine Glands......Page 12
Sebaceous Glands......Page 13
Catagen Phase......Page 14
Nail......Page 15
Suggested further Reading......Page 16
Clinical Findings......Page 17
Differential Diagnosis......Page 19
Clinical Findings......Page 20
Clinical Findings......Page 21
Histologic Features......Page 22
Histologic Features......Page 23
Clinical Findings......Page 24
Differential Diagnosis......Page 25
Histologic Features......Page 26
Clinical Findings......Page 27
Ancillary Studies......Page 28
Differential Diagnosis......Page 29
Clinical Findings......Page 31
Clinical Findings......Page 32
Differential Diagnosis......Page 33
Interface Dermatitis
......Page 34
Histologic Features......Page 36
Ancillary Studies......Page 38
Differential Diagnosis......Page 39
Histologic Features......Page 40
Differential Diagnosis......Page 42
Differential Diagnosis......Page 43
Prognosis and Treatment......Page 44
Histologic Features......Page 45
Prognosis and Treatment......Page 47
Ancillary Studies......Page 48
Histologic Features......Page 49
Clinical Findings......Page 51
Differential Diagnosis......Page 52
Differential Diagnosis......Page 53
Granulomatous Dermatitis
......Page 54
Ancillary Studies......Page 55
Prognosis and Treatment......Page 56
Ancillary Studies......Page 57
Differential Diagnosis......Page 58
Rheumatoid Nodule
......Page 59
Differential Diagnosis......Page 60
Histologic Features......Page 61
Differential Diagnosis......Page 62
Prognosis and Treatment......Page 63
Clinical Findings......Page 64
Histologic Features......Page 65
Prognosis and Treatment......Page 66
Histologic Features......Page 67
Differential Diagnosis......Page 68
Clinical Findings......Page 69
Histologic Features......Page 70
Clinical Findings......Page 71
Differential Diagnosis......Page 72
Differential Diagnosis......Page 73
Differential Diagnosis......Page 74
Miscellaneous Inflammatory Disorders
......Page 75
Differential Diagnosis......Page 76
Histologic Features......Page 77
Histologic Features......Page 78
Differential Diagnosis......Page 79
Histologic Features......Page 80
Clinical Findings......Page 81
Differential Diagnosis......Page 82
Ancillary Studies......Page 83
Prognosis and Treatment......Page 84
Differential Diagnosis......Page 85
Histologic Features......Page 86
Suggested Further Reading
......Page 87
Panniculitis Without Prominent Vasculitis......Page 88
Mixed Patterns......Page 89
Clinical Findings......Page 90
Histologic Features......Page 91
Clinical Findings......Page 92
Clinical Findings......Page 93
Differential Diagnosis......Page 94
Ancillary Studies......Page 95
Macrophagic Panniculitis......Page 96
Differential Diagnosis......Page 98
Clinical Findings......Page 100
Histologic Features......Page 101
Differential Diagnosis......Page 102
Prognosis and Treatment......Page 103
Ancillary Studies......Page 104
Morphea And Sclerodermoid Panniculitis......Page 105
Lobular Neutrophilic Panniculitis......Page 106
Eosinophilic Lobular Panniculitis......Page 107
Clinical Findings......Page 108
Differential Diagnosis......Page 109
Suggested Further Reading......Page 110
4......Page 111
Clinical Findings......Page 190
Biopsy: Timing and Choice of Lesions......Page 191
Histologic Diagnosis of Vasculitis......Page 192
Other Histologic Findings Associated with Vasculitis......Page 195
Direct Immunofluorescent Studies......Page 196
Differential Diagnosis......Page 197
Cutaneous Leukocytoclastic Angiitis......Page 200
Clinical Findings......Page 201
Clinical Findings......Page 202
Clinical Findings......Page 203
Histologic Features......Page 204
Clinical Findings......Page 205
Histologic Features......Page 206
Clinical Findings......Page 207
Histologic Features......Page 208
Clinical Findings......Page 209
Clinical Findings......Page 210
Pseudovasculitis......Page 211
Suggested Further Reading......Page 215
Histologic Features......Page 216
Ancillary Studies......Page 217
Clinical Findings......Page 218
Staphylococcal Scalded Skin Syndrome
......Page 219
Transient Neonatal Pustular Melanosis
......Page 220
Histologic Features......Page 221
Histologic Features......Page 222
Histologic Features......Page 223
Clinical Findings......Page 224
Ancillary Studies......Page 225
Prognosis and Treatment......Page 226
Clinical Findings......Page 227
Ancillary Studies......Page 228
Histologic Features......Page 229
Prognosis and Treatment......Page 230
Immunoprecipitation......Page 231
Darier’s Disease
......Page 232
Ancillary Studies......Page 233
Acantholytic Dermatosis Of The Genitocrural Region
......Page 234
Prognosis and Treatment......Page 235
Intraepidermal Blister Associated With Epidermolytic Hyperkeratosis
......Page 236
Clinical Findings......Page 237
Histologic Features......Page 238
Cicatricial Pemphigoid
......Page 239
Histologic Features......Page 240
Ancillary Studies......Page 241
Clinical Findings......Page 242
Prognosis and Treatment......Page 243
Clinical Findings......Page 244
Clinical Findings......Page 245
Differential Diagnosis......Page 246
Subepidermal Vesicular Lichenoid Dermatitis
......Page 247
Clinical Findings......Page 248
Porphyria Cutanea Tarda
......Page 249
Histologic Features......Page 250
Histologic Fe atures......Page 251
Bullous Diabeticorum
......Page 252
Blisters Caused By Heat Or Cold
......Page 253
Blisters Associated With A Superficial Dermal Neoplastic Infiltrate
......Page 254
Suggested Further Reading
......Page 255
Clinical Findings......Page 256
Histologic Features......Page 257
Scleredema......Page 258
Follicular Mucinosis......Page 259
Differential Diagnosis......Page 260
Systemic Amyloidosis......Page 261
Localized Cutaneous Amyloidosis......Page 262
Systemic Amyloidosis......Page 263
Prognosis and Treatment......Page 264
Ancillary Studies......Page 265
Histologic Features......Page 266
Clinical Findings......Page 267
Clinical Findings......Page 268
Exogenous (Foreign) Material......Page 269
Prognosis and Treatment......Page 270
Suggested Further Reading......Page 271
Clinical Findings......Page 272
Clinical Findings......Page 273
Drug-Induced Hyperpigmentation......Page 274
Prognosis and Treatment......Page 275
Histologic Features......Page 276
Ancillary Studies......Page 277
Histologic Features......Page 278
Prognosis and Treatment......Page 279
Histologic Features......Page 280
Clinical Findings......Page 281
Suggested Further Reading......Page 282
Non-Neoplastic Disorders of Hair......Page 283
Histologic Features......Page 284
Prognosis and Treatment......Page 285
Histologic Features......Page 286
Histologic Features......Page 287
Histologic Features......Page 289
Histologic Features......Page 290
Clinical Findings......Page 291
Histologic Features......Page 292
Scarring (Permanent) Alopecias......Page 293
Histologic Features......Page 294
Clinical Findings......Page 295
Histologic Features......Page 296
Histologic Features......Page 297
Prognosis and Treatment......Page 298
Gene Rearrangement and Immunohistochemical Studies......Page 299
Histologic Features......Page 300
Differential Diagnosis......Page 301
Folliculitis (Acne) Keloidalis......Page 302
Prognosis and Treatment......Page 303
Prognosis and Treatment......Page 304
Suggested Further Reading......Page 305
Cysts and Sinuses......Page 306
Cysts Arising From the Infundibular Portion of the Hair Follicle......Page 307
Differential Diagnosis......Page 308
Histologic Features......Page 309
Clinical Findings......Page 311
Histologic Features......Page 312
Clinical Findings......Page 313
Histologic Features......Page 314
Histologic Features......Page 316
Clinical Findings......Page 317
Clinical Findings......Page 318
Histologic Features......Page 319
Clinical Findings......Page 320
Prognosis and Treatment......Page 321
Histologic Features......Page 322
Clinical Findings......Page 323
Histologic Features......Page 324
Histologic Features......Page 325
Differential Diagnosis......Page 326
Differential Diagnosis......Page 327
Histologic Features......Page 328
Histologic Features......Page 329
Prognosis and Treatment of Pseudocysts......Page 330
Differential Diagnosis......Page 331
Histologic Features......Page 332
Clinical Findings......Page 333
Differential Diagnosis......Page 334
Suggested Further Reading......Page 335
Clinical Findings......Page 336
Histologic Features......Page 337
Differential Diagnosis......Page 338
Clinical Findings......Page 339
Histologic Features......Page 340
Seborrheic Keratosis versus Squamous Cell Carcinoma In Situ......Page 344
Prognosis and Treatment......Page 345
Clinical Findings......Page 346
Histologic Features......Page 347
Histologic Features......Page 348
Histologic Features......Page 349
Lichenoid Keratosis versus Inflamed Actinic Keratosis......Page 350
Clinical Findings......Page 351
Differential Diagnosis......Page 352
Clinical Findings......Page 353
Histologic Features......Page 354
Actinic Keratosis versus Benign Keratoses......Page 357
Bowenoid Squamous Cell Carcinoma In Situ (Bowen’s Disease and Its Variants)......Page 358
Histologic Features......Page 359
Differential Diagnosis......Page 361
High-Grade Dysplasia (Intraepithelial Lesion Grades II and III)......Page 362
Differentiated (Simplex-Type) of Dysplasia......Page 363
Clinical Findings......Page 364
Clinical Findings......Page 365
Histologic Features......Page 366
Warty Squamous Cell Carcinoma......Page 369
Verrucous Carcinoma......Page 370
Spindle Cell Squamous Cell Carcinoma......Page 371
Desmoplastic or Sclerosing Squamous Cell Carcinoma......Page 372
Squamous Cell Carcinoma with Single Cell Infiltrative Pattern......Page 373
Differential Diagnosis......Page 375
Invasive Versus In Situ Squamous Cell Carcinoma......Page 376
Squamous Cell Carcinoma versus Adnexal Carcinomas with Squamous Differentiation (Porocarcinoma, Trichilemmal Carcinoma)......Page 377
Squamous Cell Carcinoma versus Sarcoma......Page 378
Grades of Differentiation......Page 379
Pathologist’s Reporting of SCC......Page 380
Histologic Features......Page 381
Prognosis and Treatment......Page 382
Suggested Further Reading......Page 383
12......Page 384
13......Page 440
Clinical Findings......Page 502
Histologic Features......Page 503
Dermatofibroma versus Dermatofibrosarcoma Protuberans......Page 505
Histologic Features......Page 506
Prognosis and Treatment......Page 507
Differential Diagnosis......Page 508
Histologic Features......Page 509
Histologic Features......Page 510
Prognosis and Treatment......Page 511
Histologic Features......Page 512
Differential Diagnosis......Page 513
Histologic Features......Page 514
Clinical Findings......Page 515
Histologic Features......Page 516
Immunohistochemistry......Page 517
Dermatofibrosarcoma Protuberans versus Dermatofibroma......Page 518
Differential Diagnosis......Page 519
Histologic Features......Page 520
Prognosis and Treatment......Page 521
Histologic Features......Page 522
Histologic Features......Page 523
Ancillary Studies......Page 524
Pleomorphic Sarcoma (Malignant Fibrous Histiocytoma)......Page 525
Ancillary Studies......Page 526
Histologic Features......Page 527
Clinical Findings......Page 528
Immunohistochemistry......Page 529
Clinical Findings......Page 530
Differential Diagnosis......Page 531
Histologic Features......Page 532
Clinical Features......Page 533
Differential Diagnosis......Page 534
Clinical Findings......Page 535
Ancillary Studies......Page 536
Ancillary Studies......Page 537
Rudimentary Polydactyly......Page 538
Clinical Findings......Page 539
Differential Diagnosis......Page 540
Histologic Features......Page 541
Clinical Findings......Page 542
Ancillary Studies......Page 543
Differential Diagnosis......Page 544
Extracranial Meningioma......Page 545
Ancillary Studies......Page 546
Cutaneous Ewing’S Sarcoma......Page 547
Pyogenic Granulomas (Lobular Capillary Hemangioma)......Page 549
Spindle Cell Hemangioma......Page 550
Differential Diagnosis......Page 551
Histologic Features......Page 552
Differential Diagnosis......Page 553
Histologic Features......Page 554
Differential Diagnosis......Page 555
Clinical Findings......Page 556
Ancillary Studies......Page 557
Differential Diagnosis......Page 558
Clinical Findings......Page 559
Differential Diagnosis......Page 560
Differential Diagnosis......Page 561
Histologic Features......Page 562
Mesenchymal Chondrosarcoma......Page 563
Clinical Findings......Page 564
Prognosis and Treatment......Page 565
Cutaneous Angiomyolipoma......Page 566
SUGGESTED further READING......Page 567
15......Page 568
Letterer-Siwe Disease......Page 622
Differential Diagnosis......Page 623
Indeterminate Cell Histiocytosis......Page 624
Clinical Findings......Page 625
Differential Diagnosis......Page 626
Histologic Features......Page 627
Differential Diagnosis......Page 628
Differential Diagnosis......Page 629
Clinical Features......Page 630
Histologic Features......Page 631
Prognosis and Treatment......Page 632
Suggested Further Reading......Page 633
Histologic Features......Page 634
Immunohistochemistry......Page 636
Differential Diagnosis......Page 637
Prognosis and Treatment......Page 638
Suggested Further Reading......Page 639
Pathophysiology......Page 640
Anatomic Localization......Page 641
Biopsy Specimens......Page 642
General Comments......Page 643
Ancillary Studies......Page 645
Adenocarcinoma
......Page 646
Neuroendocrine Carcinomas
......Page 650
Melanoma
......Page 651
Suggested Further Reading
......Page 653
Mohs Technique......Page 654
Indications......Page 655
Role of the Dermatopathologist......Page 656
Suggested further Reading......Page 657
A......Page 658
B......Page 661
C......Page 663
D......Page 667
E......Page 668
F......Page 669
H......Page 671
I......Page 673
L......Page 675
M......Page 677
N......Page 679
P......Page 681
R......Page 684
S......Page 685
T......Page 688
V......Page 689
Z......Page 690
