These proceedings contain selected contributions from the participants to the Fourth International Symposium on Dendritic cells that was held in Venice (Lido) Italy, from Oc tober 5 to 10, 1996. The symposium was attended by more than 500 scientists coming from 24 different countries. Studies on dendritic cells (DC) have been greatly hampered by the difficulties in preparing sufficient cell numbers and in a reasonable pure form. At this meeting it has been shown that large quantities of DC can be generated from precursors in both mice and humans, and this possibility has enormously encouraged studies aimed to characterize DC physiology and DC-specific genes, and to employ DC therapeutically as adjuvants for im munization. The possibility of generating large numbers of autologous DC that can be used in the manipulation of the immune response against cancer and infectious diseases has tremendously boosted dendritic cell research and the role of DC in a number of medi cal areas has been heatedly discussed.
Author(s): Ralph M. Steinman, Maggie Pack, Kayo Inaba (auth.), Dr. Paola Ricciardi-Castagnoli (eds.)
Series: Advances in Experimental Medicine and Biology (417)
Edition: 1
Publisher: Springer US
Year: 1997
Language: English
Pages: 594
Tags: Immunology; Anatomy
Front Matter....Pages i-xvi
Dendritic Cell Development and Maturation....Pages 1-6
Generation of Mature Dendritic Cells from Human Blood....Pages 7-13
Growth and Differentiation of Human Dendritic Cells from CD34 + Progenitors....Pages 15-19
CD34 + Hematopoietic Progenitors from Human Cord Blood Differentiate Along two Independent Dendritic Cell Pathways in Response to GM-CSF+TNFα....Pages 21-25
Myeloid DCs Deduced from Monocytes....Pages 27-32
Dramatic Numerical Increase of Functionally Mature Dendritic Cells in FLT3 Ligand-Treated Mice....Pages 33-40
Selective Expression of Human Fascin (p55) by Dendritic Leukocytes....Pages 41-46
Dendritic-Like Cells from relB Mutant Mice....Pages 47-54
Driving Gene Expression Specifically in Dendritic Cells....Pages 55-57
Checkpoints and Functional Stages in DC Maturation....Pages 59-64
T Cell-Mediated Terminal Maturation of Dendritic cells....Pages 65-69
Migration of Cultured Chimpanzee Dendritic Cells Following Intravenous and Subcutaneous Injection....Pages 71-75
The Liver Sinusoids as a Specialized Site for Blood-Lymph Translocation of Rat Dendritic Cells....Pages 77-81
Regulation of CD44 Isoform Expression and CD44-Mediated Signaling in Human Dendritic Cells....Pages 83-90
Mouse Spleen Dendritic Cells....Pages 91-95
Migration of Dendritic Cells in 3D-Collagen Lattices....Pages 97-103
Dendritic Cells of the Murine Peyer’s Patches Colocalize with Salmonella Typhimurium Avirulent Mutants in the Subepithelial Dome....Pages 105-109
The Role of CD11c + Cells as Possible Candidates for Immature Dendritic Cells in the Murine Peyer’s Patches....Pages 111-114
The Influence of Collagen, Fibronectin, and Laminin on the Maturation of Dendritic Cell Progenitors Propagated from Normal or Flt3-Ligand-Treated Mouse Liver....Pages 115-120
Stimulation of Langerhans Cell Migration in Mice by Tumour Necrosis Factor α and Interleukin 1β....Pages 121-124
Langerhans Cells Require Signals from Both Tumour Necrosis Factor α and Interleukin 1β for Migration....Pages 125-128
α6 Integrins are Required for Langerhans Cell Migration....Pages 129-132
Functional Expression and Modulation of C5a Receptor (CD88) on Skin Dendritic Cells....Pages 133-138
Unilineage Dendritic Cell Cultures Generated by Purified Human Hematopoietic Progenitor Cells....Pages 139-143
CD14 is Expressed by Subsets of Murine Dendritic Cells and Upregulated by Lipopolysaccharide....Pages 145-159
TGF-β1 Dependent Generation of LAG + Dendritic Cells from CD34 + Progenitors in Serum-Free Medium....Pages 161-165
A Newly Identified Antigen Retention Compartment in the FSDC Precursor Dendritic Cell Line....Pages 167-169
Mannose Receptor Mediated Uptake of Antigens Strongly Enhances HLA-Class II Restricted Antigen Presentation by Cultured Dendritic Cells....Pages 171-174
Mechanisms of FcεRI-IgE-Facilitated Allergen Presentation by Dendritic Cells....Pages 175-178
Localization and Intracellular Transport of MHC Class II Molecules in Bone Marrow-Derived Dendritic Cells....Pages 179-182
Mannose Receptor Mediated Antigen Uptake and Presentation in Human Dendritic Cells....Pages 183-187
Enhanced Antigen Presenting Cell Function Following in Vivo Priming....Pages 189-193
Dendritic Cells from Mice Lacking the Invariant Chain Express High Levels of Membrane MHC Class II Molecules in Vivo ....Pages 195-201
T Lymphocyte Mediated Regulation of Costimulator Molecule Expression on Human Dendritic Cells....Pages 203-206
Activation of Immature Dendritic Cells Via Membrane Sialophorin (CD43)....Pages 207-212
Processing of Exogenous Protein Antigen by Murine Dendritic Cells for Presentation to Cytotoxic T Lymphocytes....Pages 213-220
The TH1 Lymphokine Interferon-γ is a Potent Upregulator of Dendritic Cells with Phagocytic Capacity in GM-CSF Supplemented Bone Marrow Cultures....Pages 221-225
Functional Role of CD101 on Skin Dendritic Cells....Pages 227-232
Presentation of Tetanus Toxoid to Autologous T Cells by Dendritic Cells Generated from Human Blood....Pages 233-237
The Regulation of T Cell Responses by a Subpopulation of CD8 + DEC205 + Murine Dendritic Cells....Pages 239-248
Constructing Artificial Antigen-Presenting Cells from Drosophila Cells....Pages 249-254
Role of Dendritic Cells in Induction of Tolerance and Immunity in Vivo ....Pages 255-263
B7-2 + Low Density APCS are as Effective as B7-2 − Small Resting B Cells in Inducing Specific Unresponsiveness to Minor Histocompatibility (miH) Antigen(S) in Vivo ....Pages 265-268
An Attempt to Induce Tolerance with Infusion of Donor Bone Marrow in Organ Allograft Recipients....Pages 269-274
Blocking of the B7-CD28 Pathway Increases the Capacity of FasL + (CD95L + ) Dendritic Cells to Kill Alloactivated T Cells....Pages 275-282
Generation of Nitric Oxide by Mouse Dendritic Cells and Its Implications for Immune Response Regulation....Pages 283-290
Dendritic Cells in the Autoimmune Insulitis in NOD Mouse Models of Diabetes....Pages 291-294
Dendritic Cells in Inflammatory Responses in the CNS....Pages 295-299
Th-1/Th-2 Switch Regulation in Immune Responses to Inhaled Antigens....Pages 301-306
Langerhans Cells in the TGFβ1 Null Mouse....Pages 307-310
Maturation and Migration of Murine Dendritic Cells in Situ....Pages 311-315
Antigen Presentation and IL-12 Production by Dendritic Cells in Vivo....Pages 317-321
IL-10 Prevents the Generation of Dendritic Cells from CD14+ Blood Monocytes, Promotes the Differentiation to Mature Macrophages and Stimulates Endocytosis of FITC-dextran....Pages 323-327
Human Dendritic/Langerhans Cells Control Growth and Differentiation of CD40 Activated B Cells....Pages 329-334
Activation of Dendritic Cells by Surrogate T Cell Interactions Leads to Enhanced Costimulation, Secretion of TH1-Associated Cytokines, and CTL Inductive Capacity....Pages 335-343
Soluble CD16/FcγRIII Induces Maturation of Dendritic Cells and Production of Several Cytokines Including IL-12....Pages 345-352
Induction of FcεRIα mRNA and Protein Synthesis by Interleukin 4 in CD34 + Cells-Derived Cd1a + Dendritic Cells....Pages 353-355
FACS-Sorted Spleen and Peyer’s Patch Dendritic Cells Induce Different Responses in Th0 Clones....Pages 357-362
Dendritic Cells, Obtained from Peripheral Blood Precursors in the Presence of PGE 2 , Promote Th2 Responses....Pages 363-367
Dendritic Cells and Macrophages Induce the Development of Distinct T Helper Cell Populations in Vivo ....Pages 369-373
A Potential Pathway of Th2 Development during Primary Immune Response....Pages 375-381
Dendritic Cells as Immunogens for Human CTL Responses....Pages 383-387
Dendritic Cells as Targets for Cytotoxic T Lymphocytes....Pages 389-394
Cutaneous Dendritic Cells Promote Replication of Immunodeficiency Viruses....Pages 395-399
Dendritic Cells Express and Use Multiple HIV Coreceptors....Pages 401-406
In Vitro HIV Infection of Dendritic Cell Precursors....Pages 407-410
The Role of Dendritic Cells in the Transport of HIV to Lymph Nodes Analysed in Mouse....Pages 411-414
The HIV-1 Life Cycle is Blocked at Two Different Points in Mature Dendritic Cells....Pages 415-419
Infection of Human Dendritic Cells by Measles Virus Induces Immune Suppression....Pages 421-423
Immortalized Cell Lines with Dendritic Morphology Derived from Mice Lacking Both Type I and Type II Interferon Receptors Present MHC II Restricted Antigen to T Cells and Induce Mixed Leukocyte Reactions....Pages 425-432
Infection of Human Thymic Dendritic Cells with HIV-1 Induces the Release of a Cytotoxic Factor(s)....Pages 433-438
Dendritic Cell Surface Molecules....Pages 439-442
Analysis of Dendritic Cells at the Genetic Level....Pages 443-448
Subtractive cDNA Cloning....Pages 449-454
Increased Level of Phosphotyrosine in Human Dendritic Cells under Stimulation with Contact Sensitizers but Not Irritants....Pages 455-459
Insulin-Like Growth Factor Type I (IGF-I) Supports Growth of V-relER Dendritic Cell Progenitors....Pages 461-465
Differential mRNA Expression in Untreated and TNF-α Elicited Murine Dendritic Cells Precursors....Pages 467-473
Differential Gene Expression in Cultured Human Langerhans Cells in Response to Phagocytic Stimulation....Pages 475-480
Isolation of Differentially Expressed Genes in Epidermal Langerhans Cells....Pages 481-486
Absence of Follicular Dendritic Cells (FDC) in Mutant Mice with Deficient TNF/Lymphotoxin (LT) Signaling....Pages 487-491
A Role for CR2 in FDC-B Cell Interactions....Pages 493-497
Disappearance of the Antigen Exchanging Ability of FDC Induced by Repeated Antigen Injections....Pages 499-502
In Vitro Priming to Tumor-Associated Proteins....Pages 503-509
Development of Dendritic Cell-Based Genetic Vaccines for Cancer....Pages 511-518
Immunotherapy of Cancer....Pages 519-524
Tumor-Infiltrating Dendritic Cells are Defective in Their Antigen-Presenting Function and Inducible B7 Expression....Pages 525-528
Role of B7 Costimulation in the Induction of T and B Cell Responses by Dendritic Cells in vivo ....Pages 529-533
Positive and Negative Regulation of Dendritic Cell Function by Lipopolysaccharide in Vivo ....Pages 535-540
Dendritic Cells Induce Immunity to Cutaneous Leishmaniasis in Mice....Pages 541-545
Immune Response in Dendritic Cell Depleted Mice....Pages 547-550
Dendritic Cell Based Therapy of Cancer....Pages 551-569
Identification and Isolation of CD1a Positive Putative Tumour Infiltrating Dendritic Cells in Human Breast Cancer....Pages 571-577
Dendritic Cells and Interleukin 12 as Adjuvants for Tumor-Specific Vaccines....Pages 579-582
Generation of in Vitro Autologous Human Cytotoxic T-Cell Response to E7 and HER-2/Neu Oncogene Products Using Ex-Vivo Peptide Loaded Dendritic Cells....Pages 583-589
Back Matter....Pages 591-593
