These Proceedings contain the contributions of the partIcIpants of the Third International Symposium on Dendritic Cells that was held in Annecy, France, from June 19 to June 24, 1994. This symposium represented a follow-up of the first and second international symposia that were held in Japan in 1990 and in the Netherlands in 1992. Dendritic cells are antigen-presenting cells, and are found in all tissues and organs of the body. They can be classified into: (1) interstitial dendritic cells of the heart, kidney, gut, and lung;(2) Langerhans cells in the skin and mucous membranes; (3) interdigitating dendritic cells in the thymic medulla and secondary lymphoid tissue; and (4) blood dendritic cells and lymph dendritic cells (veiled cells). Although dendritic cells in each of these compartments are all CD45+ leukocytes that arise from the bone marrow, they may exhibit differences that relate to maturation state and microenvironment. Dendritic cells are specialized antigen-presenting cells for T lymphocytes: they process and present antigens efficiently in situ, and stimulate responses from naive and memory T cells in the paracortical area of secondary lymphoid organs. Recent evidence also demonstrates their role in induction of tolerance. By contrast, the primary and secondary B-cell follicles contain follicular dendritic cells that trap and retain intact antigen as immune complexes for long periods of time. The origin of follicular dendritic cells is not clear, but most investigators believe that these cells are not leukocytes.
Author(s): C. Caux, B. Vanbervliet, C. Massacrier, B. Dubois, C. Dezutter-Dambuyant, D. Schmitt (auth.), Dr. Jacques Banchereau, Dr. Daniel Schmitt (eds.)
Series: Advances in Experimental Medicine and Biology (378)
Edition: 1
Publisher: Springer US
Year: 1995
Language: English
Pages: 572
Tags: Hematology; Immunology; Animal Anatomy / Morphology / Histology; Plant Sciences
Front Matter....Pages i-xix
Characterization of Human CD34 + Derived Dendritic/Langerhans Cells (D-Lc)....Pages 1-5
Stem Cell Factor Enhances Dendritic Cell Development....Pages 7-11
Synergistic Interaction between c-kit Ligand (SCF), GM-CSF and TNF Promotes Optimal Dendritic Langerhans Cell Proliferation from Primitive Progenitors in Human Bone Marrow....Pages 13-16
Progenitor Recruitment and in Vitro Expansion of Immunostimulatory Dendritic Cells from Human CD34 + Bone Marrow Cells by c- kit -Ligand, GM-CSF, and TNFα....Pages 17-20
Thymic Dendritic Cells: Surface Phenotype, Developmental Origin and Function....Pages 21-29
Recombinant GM-CSF Induces Cytokine Production in Mouse Dendritic Cell Clones....Pages 31-34
Review of the Characteristics of Six Cell Lines with Langerhans Cell Phenotype....Pages 35-37
Immortalized Murine Dendritic Cells: Phenotypic and Functional Characterization....Pages 39-41
Production and Properties of Large Numbers of Dendritic Cells from Human Blood....Pages 43-52
A Simplified Method for Growing Dendritic Cells from Rat Bone Marrow....Pages 53-55
Transition of T 3 -Induced Monocyte-Derived Veiled/Dendritic Cells into Macrophage-Like Cells by Lipopolysaccharide....Pages 57-59
Immunophenotypical and Functional Characterization of Bone Marrow Derived Dendritic Cells....Pages 61-63
Expression of B7 Costimulator Molecules on Mouse Dendritic Cells....Pages 65-70
Development of Rat DC by in Vitro Culture of Bone Marrow Cells....Pages 71-73
Dendritic Cells Differentiated from Human Monocytes through a Combination of IL-4, GM-CSF and IFN-γ Exhibit Phenotype and Function of Blood Dendritic Cells....Pages 75-78
Functional CD40 Antigen on B Cells, Dendritic Cells and Fibroblasts....Pages 79-83
Characterization of Human Blood Dendritic Cells: Cytokine Profiles....Pages 85-87
Purification of Human Lung Dendritic Cells by Three Color Flow Cytometry....Pages 89-91
Identification of a Novel Cell Surface Protein Expressed by Murine Epidermal Langerhans Cells and Some Lymphoid Dendritic Cells....Pages 93-95
Characterisation of Adhesion Molecules on the Surface of Dendritic Cells Isolated from Human Blood....Pages 97-99
In Situ Expression of Activation Markers by Langerhans’ Cells Containing GM-CSF....Pages 101-103
Phenotypic Variation and Functional Differences within Dendritic Cells Isolated from Afferent Lymph....Pages 105-107
Expression of Somatostatin on Langerhans Cells....Pages 109-110
Dermal Dendritic Cells are Important Members of the Skin Immune System....Pages 111-116
Expression of CD44 Antigen by Langerhans Cells and Thy1+ Dendritic Epidermal Cells - Ontogenetic Variation and Its Role in Migration....Pages 117-119
Distribution of Human Colonic Dendritic Cells and Macrophages - Functional Implications....Pages 121-123
Morphologic and Antigenic Features of Dendritic Cells in Immune-Mediated Dermatoses: A Hypothesis of Differentiation....Pages 125-128
Tumor Necrosis Factor Receptors of the Monocyte Derived Langerhans Cell Phenotype “MoLC”....Pages 129-133
Expression of the High Affinity Receptor for Immunoglobulin E (IgE) by Dendritic Cells in Normals and Asthmatics....Pages 135-138
A Comparative Study on Langerhans Cells in Lymph Nodes with Dermatopathic Lymphadenopathy and Histiocytosis X Cells....Pages 139-141
Role of the Interaction of Fibronectin with Epidermal Langerhans Cells in Regulating Their Migratory Pathway....Pages 143-145
Expression of Neuropeptides on Human Epidermal Langerhans Cells....Pages 147-150
Monocyte Derived Dendritic Cells (MODC) Present Phenotype and Functional Activities of Langerhans Cells / Dendritic Cells....Pages 151-153
Development and Distribution of T Cell-Associated Dendritic Cells in Organs and Tissues of Mice Depleted of Blood Monocytes by Administration of Strontium-89....Pages 155-157
Establishment and Characterization of Antigen-Presenting Cell Lines (XS Series) Derived from Newborn Mouse Epidermis....Pages 159-162
Migration of Rat Dendritic Cells and Macrophages from the Peritoneal Cavity to the Parathymic Lymph Nodes....Pages 163-167
In Vitro Migration Capacity of Epidermal Langerhans Cells....Pages 169-171
Epidermal Langerhans Cell Migration: Signals and Mechanisms....Pages 173-175
Population Dynamics and Functions of Respiratory Tract Dendritic Cells in the Rat....Pages 177-181
Regulation of the Humoral Response by the Antigen-Presenting Cells in Vivo ....Pages 183-185
Antigen Presenting and Primary in Vitro Sensitizing Capacity of CD1a + Dendritic Cells Generated from Human Blood....Pages 187-189
Annexin Expression in Human Dendritic Cells....Pages 191-193
Spleen Accessory Cell Antigen Processing and in vitro Induction of Specific Lymphocyte Proliferation in BALB/c Mice Infested with Nymphal Ixodes ricinus Ticks....Pages 195-197
Functional Dichotomy of Dendritic Cells Isolated from Blood and Lymph Nodes....Pages 199-201
Antigen Processing Capacity of Dendritic Cells from Mice of Different MHC Backgrounds: Down-Regulation upon Culture and Evidence for Heterogeneity of Dendritic Cell Populations....Pages 203-206
TNFα Interrupts Antigen-Presenting Function of Langerhans Cells by Two Mechanisms: Loss of Immunogenic Peptides and Impairment of Antigen-Independent T Cell Clustering....Pages 207-209
The Role of Cis -Urocanic Acid in UVB-Induced Immunosuppression....Pages 211-213
Antigen Processing by Rat Lymph-Borne Dendritic Cells....Pages 215-217
Evidence that Langerhans Cells Migrate to Regional Lymph Nodes During Experimental Contact Sensitization in Dogs....Pages 219-221
Analysis of Invariant Chain Processing in 3 Day Cultured Rat Langerhans Cells....Pages 223-225
Functional and Ultrastructural Aspects of Antigen Processing by Dendritic Cells....Pages 227-231
Processing and Presentation of Protein and Parasite-Derived Antigens by 4F7 + Dendritic Cells....Pages 233-235
Dendritic Cells Migrating from Carcinogen-Treated Skin Have Reduced Antigen-Presenting Function....Pages 237-241
Inhibitory Effects of Ultraviolet B on Human Langerhans Cell Antigen Presenting Function....Pages 243-245
Phenotype of Cells Migrated from Human Skin Explants....Pages 247-251
Uptake of Bead-Adsorbed Versus Soluble Antigen by Bone Marrow Derived Dendritic Cells Triggers Their Activation and Increases Their Antigen Presentation Capacity....Pages 253-255
Ectromelia Virus Establishes a Persistent Infection in Spleen Dendritic Cells and Macrophages of BALB/c Mice following the Acute Disease....Pages 257-261
Functional Expression of ICAM-3 on Human Epidermal Langerhans Cells....Pages 263-265
Multiple Lines of Evidence Favoring a Bone Marrow Derivation of Follicular Dendritic Cells (FDCs)....Pages 267-272
Adhesion and Costimulatory Molecules on Human FDC in Vitro....Pages 273-275
Architectural and Antigenic Features of Follicular Dendritic Cells as a Clue to the Histogenesis of Primary Cutaneous B-Cell Lymphoma....Pages 277-279
An Immunohistochemical Study on Isotypes of the Immune Complexes Trapped by Follicular Dendritic Cells (FDC) in Various Human Lymphoid Tissues....Pages 281-283
The Interdependence of Lymphocyte, Stromal Cell, and Follicular Dendritic Cell Maturation....Pages 285-288
The Monoclonal Antibody FDC-M1 Recognizes Possible Follicular Dendritic Cell Precursors in the Blood and Bone Marrow....Pages 289-291
Expression of Complement Regulating Proteins on FDC....Pages 293-295
Distribution and Characterization of Follicular Dendritic Cells (FDCs) in Non-Hodgkin’s Lymphomas....Pages 297-299
Follicular Dendritic Cells Induce B Cell Activation....Pages 301-304
Germinal Center T Cells: Analysis of Their Proliferative Capacity....Pages 305-307
Iccosomes and Induction of Specific Antibody Production in Vitro....Pages 309-311
Localizations of Regulatory Proteins of Complement Components on RA Synovial Tissues — Especially Germinal Centers....Pages 313-315
In Vitro Immune Complex Binding Assay to Examine the Mechanism of Immune Complex Trapping by Human Follicular Dendritic Cells (FDC)....Pages 317-319
SIV Infection of Follicular Dendritic Cells (FDC) and Other Spleen Cell Subsets in Experimentally Infected Cynomolgus Monkeys....Pages 321-327
Morpho-Functional Changes of Follicular Dendritic Cells (FDC) and Lymph Node Structure in Simian Immunodeficiency Virus (SIV) Infection....Pages 329-331
Modulation of B Lymphocyte Proliferation Inside the Germinal Center....Pages 333-335
Human Follicular Dendritic Cells Promote Both Proliferation and Differentiation of CD40 Activated B Cells....Pages 337-339
Dendritic Cells as Stimulator Cells of MHC Class I-Restricted Immune Responses....Pages 341-345
Dendritic Cells Regulate Development of Alloantigenic and Mitogenic T H l Versus T H 2 Responses....Pages 347-349
New Molecules on Dendritic Cells and Their Interactions with T Lymphocytes....Pages 351-354
Phenotype and Alloactivating Capacity of Dendritic Cells Generated under Different Culture Conditions from Human Peripheral Blood....Pages 355-357
Inhibitory Effect of IL-10 on Human Langerhans Cell Antigen Presenting Function....Pages 359-361
IL-10 Inhibits the Primary Allogeneic T Cell Response to Human Peripheral Blood Dendritic Cells....Pages 363-365
A Molecular Strategy to Identify Molecules that Are Specific for Dendritic Cells and/or Critical to Their Unique Immunostimulatory Function....Pages 367-369
Activation of Primary Allogeneic CD8+ T Cells by Dendritic Cells Generated in Vitro from CD34+ Cord Blood Progenitor Cells....Pages 371-374
Stimulation of Human Anti-Viral CD8+ Cytolytic T Lymphocytes by Dendritic Cells....Pages 375-379
T-Lymphocyte Proliferation Stimulated by αβTCR/CD2 Bispecific Antibody is Dependent on LFA- 1/ICAM-1 Recognition of Accessory Cells....Pages 381-383
Low Reactivity of Peripheral Blood Dendritic Cells Respond to IL-1 and GM-CSF in SLE Patients....Pages 385-387
Defect of the CTLA4-Ig Ligands on Tumor-Infiltrating Dendritic Cells....Pages 389-392
Mixed Epidermal Cell Lymphocyte Reaction: HLA-DR + Cells Exhibit a Greater Immunostimulatory Activity than CD1a + Cells....Pages 393-396
Human Dendritic Cells Enhance Growth and Differentiation of CD40 Activated B Cells....Pages 397-399
Human Dendritic Cells Can Drive CD40-Activated slgD+ B Cells to Mount Mucosal-Type Humoral Response....Pages 401-403
Factors Affecting Spontaneous Dendritic Cell-Lymphocyte Clustering in Skin Afferent Lymph....Pages 405-407
Characteristics of Antigen-Independent and Antigen-Dependent Interaction of Dendritic Cells with CD4+T Cells....Pages 409-411
Priming of T Cells with Dendritic, Macrophage and B Cell Lines in Vivo Requires More than Surface Expression of MHC II and B7 Molecules - Possible Role of CD44 and Integrins....Pages 413-417
Identification of Novel cDNAs Derived from Human Lung Dendritic Cells Using a Subtractive Cloning Approach....Pages 419-422
Mechanisms of Retrovirally Induced Immunosuppression Acting via Dendritic Cells....Pages 423-427
Preferential Entry and Productive Infection of CD4 Expressing Lymphoid Dendritic Cells by Macrophage-Tropic HIV-1....Pages 429-433
Expression of Cytokine mRNA by Human Peripheral Blood Dendritic Cells Stimulated with Human Immunodeficiency Virus and Herpes Simplex Virus....Pages 435-437
Splenic Interdigitating Dendritic Cells in Humans: Characterization and HIV Infection Frequency in Vivo ....Pages 439-441
HIV Infection of Blood Dendritic Cells in Vitro and in Vivo....Pages 443-445
In Vivo and in Vitro Infection of Human Langerhans Cells by HIV-1....Pages 447-451
In Vitro Infection of Human Epidermal Langerhans Cells with Human Immunodeficiency Virus Type 1....Pages 453-455
Dendritic Cell-T Cell Conjugates that Migrate from Normal Human Skin are an Explosive Site of Infection for HIV-1....Pages 457-460
Cell-Cell Interactions Regulate Dendritic Cell-Dependent HIV-1 Production in CD4 + T Lymphocytes....Pages 461-463
In Vitro HIV-1 Infection of Isolated Epidermal Langerhans Cells with a Cell-Free System....Pages 465-468
Defects in the Function of Dendritic Cells in Murine Retroviral Infection....Pages 469-472
Human Epidermal Langerhans Cells Efficiently Present HIV-1 Antigens to Specific T Cell Lines....Pages 473-475
Infection of Cultured Immature Dendritic Cells with Human Immunodeficiency Virus Type 1....Pages 477-479
Discontinuous Distribution of HIV-1 Quasispecies in Epidermal Langerhans Cells of an AIDS Patient and Evidence for Double Infection....Pages 481-483
Conditional Ablation of Dendritic Cells in Mice: Comparison of Two Animal Models....Pages 485-487
Activation of an HIV-LTR-CAT Transgene in Murine Macrophages by Interferon-γ in Synergism with other Cytokines or Endotoxin....Pages 489-492
Dendritic Cells, Apoptosis and Murine Retrovirus....Pages 493-496
Early Events in Contact Sensitivity....Pages 497-500
Dendritic Cells Can Be Used as Physiological Adjuvant in Vivo....Pages 501-505
Dendritic Cells Seclude Leishmania Parasites that Persist in Cured Mice — A Role in the Maintenance of T-Cell Memory?....Pages 507-509
Exposure to Type-I Collagen Induces Maturation of Mouse Liver Dendritic Cell Progenitors....Pages 511-518
Human Keratinocyte-Derived IL-12 Affects LC-Induced Allogeneic T-Cell Responses....Pages 519-521
Studies on Langerhans Cell Phenotype in Human Afferent Skin Lymph from Allergic Contact Dermatitis....Pages 523-525
Rosettes of Langerhans Cells and Activated T Cells in Human Skin Lymph Derived from Irritant Contact Dermatitis....Pages 527-529
Migration of Interleukin-6 Producing Langerhans Cells to Draining Lymph Nodes following Skin Sensitization....Pages 531-533
The Role of Cytokines in the Pathogenesis of Pulmonary Langerhans’ Cell Histiocytosis....Pages 535-537
Importance of HLA-DR+ and CD1a+ Epidermal Cells for Cytokine Production in Psoriasis....Pages 539-541
Isolation of Dendritic Leukocytes from Mouse Liver....Pages 543-548
Electronmicroscopic Study of Canine Cutaneous Histiocytoma : A Benign Langerhans Cell Tumor....Pages 549-551
Isolation and Characteristics of Dendritic Cell Progenitors from the Bone Marrow of the Hodgkin’s Disease Patients....Pages 553-555
Defective Dendritic Cell (DC) Function in a HLA-B27 Transgenic Rat Model of Spondyloarthropathy (SpA)....Pages 557-559
Improved Isolation of Dendritic Cells in Chronic Arthritic Joints Reveals No B7 (CD80) Surface Expression....Pages 561-563
Vaccine Adjuvancy: A New Potential Area of Development for GM-CSF....Pages 565-569
Back Matter....Pages 571-572
