The cytoskeleton is comprised of a variety of specialized proteins, and is a dynamic structure that is involved in the majority of key cellular events. There is increasing interest in the role of the cytoskeleton in human disease. This volume brings together human disease states where cytoskeletal disruptions are driving disease. Our emerging understanding of the molecular and cellular events that drive cytoskeletal mediated diseases including cancer, heart disease, myopathies and skin disorders, are also helping shape targeted therapeutic approaches to treating these diseases.
Author(s): Vera Dugina, Richard Arnoldi, Paul A. Janmey, Christine Chaponnier (auth.), Maria Kavallaris (eds.)
Edition: 1
Publisher: Humana Press
Year: 2012
Language: English
Pages: 456
Tags: Cell Biology; Cell Cycle Analysis; Cell Physiology; Biochemistry, general; Cancer Research
Front Matter....Pages 1-1
Front Matter....Pages 1-1
ACTIN....Pages 3-28
Microtubules....Pages 29-53
The Kinesin Superfamily....Pages 55-72
Basics of the Cytoskeleton: Myosins....Pages 73-100
Front Matter....Pages 101-101
The Actin Cytoskeleton and Membrane Organisation in T Lymphocytes....Pages 103-121
Thin Filament Diseases of Striated Muscle....Pages 123-140
Filamins and Disease....Pages 141-158
LIM Kinase and Cancer Metastasis....Pages 159-168
Actin Mutations and Deafness....Pages 169-180
Therapeutic Targeting of the Actin Cytoskeleton in Cancer....Pages 181-200
Front Matter....Pages 201-201
Microtubules as a Target in Cancer Therapy....Pages 203-221
Microtubules, Drug Resistance, and Tumorigenesis....Pages 223-240
Posttranslational Modifications of Tubulin....Pages 241-257
Stathmin and Cancer....Pages 259-284
The Biology and Pathobiology of Tau Protein....Pages 285-313
Tubulin-Related Malformations of Cortical Development....Pages 315-341
Front Matter....Pages 343-343
Spectrins in Human Diseases....Pages 345-374
Laminopathies....Pages 375-409
Desmin and Heart Disease....Pages 411-424
Neurodegenerative Diseases and Intermediate Filaments....Pages 425-448
Back Matter....Pages 434-434
