This new edition examines the latest diagnostic techniques for the interpretation of a complete range of cytological specimens. It is concise, yet covers all of the organ systems in which the procedure is used, with the number of pages devoted to each body site proportional to the clinical relevance of cytology for that site. Inside, you'll find new information on ductal lavage cytology and expanded coverage of FNA performance, keeping you current with the newest procedures. Over 700 full-color illustrations provide you with a real-life perspective of a full range of cytologic findings. Each chapter includes a discussion of indications and methods, along with a section on differential diagnosis accompanied by ancillary diagnostic techniques such as immunohistochemistry and molecular biology, where appropriate. As an Expert Consult title, it includes online access to the complete text of the book, fully searchable-as well as all of the images downloadable for your personal use-at www.expertconsult.com.
- Offers comprehensive coverage of everyday diagnostic work in a concise format for a practical benchside manual.
- Covers every type of cytology-gynecology, non-gynecology, and FNA.
- Presents an in-depth differential diagnosis discussion for all major entities.
- Examines the role of special techniques such as immunohistochemistry, flow cytometry, and molecular biology in resolving difficulties in interpretation and diagnosis.
- Provides an in-depth analysis of common diagnostic pitfalls to assist with daily signing out and reporting.
- Features coverage of patient management in discussions of pertinent clinical features.
- Uses capsule summaries featuring easy-to-read bulleted text that provide a quick review of key differential diagnoses, diagnostic pitfalls, cytomorphologic features, and tissue acquisition protocols for specific entities.
- Includes over 700 full-color illustrations that provide you with a real-life perspective of a full range of cytologic findings.
- Features anytime, anywhere online access to the complete text of the book, fully searchable-as well as all of the images downloadable for your personal use-at www.expertconsult.com.
- Covers automated cytology and HPV testing in Cervical and Vaginal Cytology chapter, providing an up-to-date reference on the techniques used in today's labs.
- Offers new information on ductal lavage cytology and expanded coverage of FNA performance, keeping you current with the newest procedures.
- Discusses the implementation of proficiency testing and changes in laboratory inspection and accreditation.
- Includes recommendations from the 2008 National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference.
Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Author(s): Edmund S. Cibas MD, Barbara S. Ducatman MD
Edition: 3
Publisher: Saunders
Year: 2009
Language: English
Pages: 536
Cover......Page p0001.djvu
Preface to Third Edition......Page p0004.djvu
Contributors......Page p0005.djvu
Acknowledgments......Page p0006.djvu
1. Cervical and Vaginal Cytology......Page p0007.djvu
The History of the Pap Test......Page p0008.djvu
Liquid-Based Cytology......Page p0009.djvu
MonoPrep Pap Test......Page p0010.djvu
FocalPoint Slide Profiler......Page p0012.djvu
ThinPrep Imaging System......Page p0013.djvu
Diagnostic Terminology and Reporting Systems......Page p0014.djvu
Specimen Adequacy......Page p0015.djvu
Interpretation and Results......Page p0016.djvu
Squamous Cells......Page p0017.djvu
Endocervical Cells......Page p0019.djvu
Exfoliated Endometrial Cells......Page p0020.djvu
Trophoblastic Cells and Decidual Cells......Page p0022.djvu
Lactobacilli......Page p0024.djvu
Shift in Flora Suggestive of Bacterial Vaginosis......Page p0025.djvu
Actinomyces......Page p0027.djvu
Herpes Simplex......Page p0028.djvu
Cytomegalovirus......Page p0029.djvu
Benign Squamous Changes......Page p0030.djvu
Benign Endocervical Changes......Page p0031.djvu
Repair......Page p0032.djvu
Radiation Changes......Page p0033.djvu
Other Benign Changes......Page p0034.djvu
Squamous Intraepithelial Lesions......Page p0035.djvu
Grading Squamous Intraepithelial Lesions......Page p0036.djvu
Low-Grade Squamous Intraepithelial Lesion......Page p0037.djvu
High-Grade Squamous Intraepithelial Lesion......Page p0038.djvu
Avoiding Overdiagnosis of Low-Grade Squamous Intraepithelial Lesions......Page p0042.djvu
Squamous Cell Carcinoma......Page p0043.djvu
Atypical Squamous Cells......Page p0046.djvu
Atypical Squamous Cells of Undetermined Significance......Page p0047.djvu
Atypical Squamous Cells, Cannot Exclude High-Grade Squamous Intraepithelial Lesion......Page p0049.djvu
Endocervical Adenocarcinoma \nin Situ......Page p0050.djvu
Endocervical Adenocarcinoma......Page p0052.djvu
Endometrial Adenocarcinoma......Page p0054.djvu
Differential Diagnosis of Adenocarcinoma......Page p0057.djvu
Atypical Endometrial Cells......Page p0058.djvu
Malignant Melanoma......Page p0059.djvu
Metastatic Tumors......Page p0060.djvu
Endometrial Cells in Women Older than 40 Years of Age......Page p0061.djvu
References......Page p0064.djvu
2. Respiratory Tract......Page p0070.djvu
Normal Anatomy, Histology, and Cytology of the Respiratory Tract......Page p0071.djvu
Bronchial Aspirations and Washings......Page p0072.djvu
Transbronchial Fine-Needle Aspiration......Page p0073.djvu
Percutaneous Fine-Needle Aspiration......Page p0074.djvu
Benign Squamous Cell Changes......Page p0075.djvu
Repair......Page p0076.djvu
Noncellular Elements and Specimen Contaminants......Page p0077.djvu
Adenovirus......Page p0079.djvu
Bacterial Pneumonias......Page p0080.djvu
Coccidioidomycosis......Page p0081.djvu
Sporotrichosis......Page p0082.djvu
Echinococcosis (Hydatid Disease)......Page p0083.djvu
Sarcoidosis......Page p0084.djvu
Pulmonary Alveolar Proteinosis......Page p0085.djvu
Inflammatory Myofibroblastic Tumor......Page p0086.djvu
Preneoplastic Changes of the Respiratory Epithelium......Page p0087.djvu
Lung Cancer......Page p0088.djvu
Squamous Cell Carcinoma......Page p0089.djvu
Adenocarcinoma......Page p0091.djvu
Large Cell Carcinoma......Page p0094.djvu
Sarcomatoid Carcinoma......Page p0096.djvu
Typical Carcinoid......Page p0097.djvu
Small Cell Carcinoma......Page p0098.djvu
Sarcomas......Page p0100.djvu
Lymphomas and Leukemias......Page p0101.djvu
Metastatic Cancers to the Lung......Page p0102.djvu
References......Page p0103.djvu
3. Urine and Bladder Washings......Page p0109.djvu
Upper Tract Washings and Brushings......Page p0110.djvu
Urine......Page p0111.djvu
Normal Elements......Page p0113.djvu
Infections......Page p0115.djvu
Noninfectious Findings and Conditions......Page p0116.djvu
Effects of Radiation and Chemotherapy......Page p0117.djvu
Urothelial Neoplasms......Page p0118.djvu
Papillary Urothelial Neoplasm of Low Malignant Potential and Low-Grade Urothelial Carcinoma......Page p0119.djvu
High-Grade Urothelial Carcinoma and Carcinoma in Situ......Page p0121.djvu
Squamous Cell Carcinoma......Page p0123.djvu
Diagnosing Difficult or BoRderline Specimens: Common Patterns......Page p0124.djvu
Ancillary Techniques......Page p0127.djvu
References......Page p0128.djvu
Specimen Collection, Preparation, and Reporting Terminology......Page p0132.djvu
Accuracy......Page p0133.djvu
Benign Elements......Page p0134.djvu
Acute Serositis......Page p0135.djvu
Rheumatoid Pleuritis......Page p0136.djvu
Other Non-Neoplastic Conditions......Page p0137.djvu
Malignant Effusions......Page p0138.djvu
Diffuse Malignant Mesothelioma......Page p0139.djvu
Mesothelioma versus Reactive Mesothelial Cells......Page p0140.djvu
Mesothelioma versus Adenocarcinoma......Page p0141.djvu
Mesothelioma versus Squamous Cell Carcinoma......Page p0143.djvu
Primary Effusion Lymphoma......Page p0144.djvu
Adenocarcinoma......Page p0145.djvu
Squamous Cell Carcinoma......Page p0148.djvu
Melanoma......Page p0149.djvu
Non-Hodgkin Lymphoma......Page p0150.djvu
Hodgkin Lymphoma......Page p0152.djvu
Germ Cell Tumors......Page p0153.djvu
References......Page p0154.djvu
Specimen Collection, Preparation, and Reporting Terminology......Page p0157.djvu
The Normal Peritoneal Washing......Page p0158.djvu
Endosalpingiosis and Similar Benign Proliferations......Page p0160.djvu
Endometriosis......Page p0161.djvu
Ovarian Cancer......Page p0162.djvu
Endometrial Cancer......Page p0165.djvu
Cervical Cancer......Page p0167.djvu
Other Malignancies......Page p0169.djvu
Monitoring Response to Treatment (“Second-Look Procedures”)......Page p0170.djvu
References......Page p0171.djvu
Obtaining and Preparing \rthe Specimen......Page p0173.djvu
Reporting Terminology......Page p0174.djvu
Normal Elements......Page p0175.djvu
Abnormal Inflammatory Cells......Page p0177.djvu
Acute Bacterial Meningitis......Page p0178.djvu
Aseptic Meningitis......Page p0180.djvu
Toxoplasmosis......Page p0181.djvu
Neoplasms......Page p0182.djvu
Carcinoma of the Lung......Page p0183.djvu
Carcinoma of the Breast......Page p0184.djvu
Acute Lymphoblastic Leukemia......Page p0185.djvu
Acute Myeloid Leukemia......Page p0186.djvu
Chronic Myeloproliferative Diseases......Page p0187.djvu
Primary Central Nervous \rSystem Lymphoma......Page p0188.djvu
Medulloblastoma......Page p0190.djvu
Astrocytomas and Glioblastoma......Page p0191.djvu
Ependymoma......Page p0192.djvu
Choroid Plexus Tumors......Page p0193.djvu
Germ Cell Tumors......Page p0194.djvu
References......Page p0195.djvu
Better Recognition of Lymphoid Cells......Page p0198.djvu
Sample Collection......Page p0199.djvu
Accuracy......Page p0200.djvu
Infections......Page p0201.djvu
Epithelial Repair......Page p0202.djvu
Barrett’s Esophagus......Page p0203.djvu
Dysplasia in Barrett’s Esophagus......Page p0204.djvu
Adenocarcinoma of the Esophagus......Page p0205.djvu
Squamous Cell Carcinoma of \rthe Esophagus......Page p0206.djvu
Dysplasia and Gastric Adenomas......Page p0208.djvu
Adenocarcinoma of the Stomach......Page p0210.djvu
Endocrine Tumors (Including Carcinoid Tumor)......Page p0211.djvu
Non-Hodgkin Lymphoma......Page p0212.djvu
Gastrointestinal Stromal Tumor......Page p0213.djvu
Infections......Page p0215.djvu
Colon......Page p0216.djvu
References......Page p0217.djvu
Nipple Discharge, Nipple Aspiration, and Ductal Lavage......Page p0222.djvu
Fine-Needle Aspiration Cytology......Page p0225.djvu
Reporting Terminology......Page p0226.djvu
Evaluation of the Specimen......Page p0227.djvu
Nonproliferative Fibrocystic Changes......Page p0228.djvu
Proliferative Fibrocystic Changes......Page p0229.djvu
Fibroadenoma......Page p0230.djvu
Pregnancy and Lactational Changes......Page p0232.djvu
Fat Necrosis......Page p0233.djvu
Radiation Change......Page p0234.djvu
Gynecomastia......Page p0235.djvu
Papillary Neoplasms......Page p0236.djvu
Phyllodes Tumor......Page p0237.djvu
Invasive Ductal Carcinoma......Page p0238.djvu
Invasive Lobular Carcinoma......Page p0240.djvu
Mucinous (Colloid) Carcinoma......Page p0242.djvu
Tubular Carcinoma......Page p0243.djvu
Metaplastic Carcinomas......Page p0244.djvu
Apocrine Carcinoma......Page p0245.djvu
Adenoid Cystic Carcinoma......Page p0246.djvu
Sarcoma......Page p0247.djvu
Metastatic Tumors......Page p0248.djvu
References......Page p0249.djvu
9. Thyroid......Page p0256.djvu
Aspiration Technique and Slide Preparation......Page p0257.djvu
Terminology for Reporting Results......Page p0258.djvu
Evaluation of the Specimen......Page p0259.djvu
Benign Follicular Nodules......Page p0260.djvu
Subacute (de Quervain) Thyroiditis......Page p0265.djvu
Black Thyroid......Page p0267.djvu
Radiation Changes......Page p0268.djvu
Suspicious for a Follicular Neoplasm......Page p0269.djvu
Suspicious for a Huumlrthle Cell Neoplasm......Page p0270.djvu
Papillary Carcinoma......Page p0272.djvu
Undifferentiated (Anaplastic) Carcinoma......Page p0276.djvu
Medullary Thyroid Carcinoma......Page p0278.djvu
Lymphoma......Page p0280.djvu
Parathyroid Tumors......Page p0282.djvu
References......Page p0283.djvu
Rationale, Indications, and Technical Considerations......Page p0286.djvu
Diagnostic Overview......Page p0287.djvu
The Normal Aspirate......Page p0289.djvu
Acute and Chronic Sialadenitis......Page p0290.djvu
Lymphoepithelial Sialadenitis......Page p0292.djvu
Squamous-Lined Cysts......Page p0293.djvu
Mucin-Containing Cysts......Page p0295.djvu
Pleomorphic Adenoma......Page p0296.djvu
Myoepithelioma......Page p0297.djvu
Basal Cell Adenoma......Page p0300.djvu
Warthin Tumor......Page p0302.djvu
Oncocytoma......Page p0303.djvu
Mucoepidermoid Carcinoma......Page p0304.djvu
Acinic Cell Carcinoma......Page p0306.djvu
Adenoid Cystic Carcinoma......Page p0307.djvu
Salivary Duct Carcinoma......Page p0310.djvu
Epithelial-Myoepithelial Carcinoma......Page p0311.djvu
Clear Cell Carcinoma, Not Otherwise Specified......Page p0312.djvu
Squamous Cell Carcinoma......Page p0313.djvu
Lymphoma Involving the Salivary Gland......Page p0314.djvu
References......Page p0315.djvu
11. Lymph Nodes......Page p0320.djvu
Reporting Terminology and Accuracy......Page p0321.djvu
Ancillary Studies......Page p0322.djvu
Flow Cytometry......Page p0323.djvu
Molecular Genetic Studies......Page p0324.djvu
Reactive Hyperplasia......Page p0325.djvu
Miscellaneous Benign Lymphadenopathies......Page p0327.djvu
Bacterial and Fungal Lymphadenitis......Page p0328.djvu
Cat Scratch Disease......Page p0329.djvu
Mycobacterial Lymphadenitis......Page p0330.djvu
Rosai-Dorfman Disease (Sinus Histiocytosis with Massive Lymphadenopathy)......Page p0331.djvu
Infectious Mononucleosis......Page p0332.djvu
Neoplasms......Page p0333.djvu
Hodgkin Lymphoma......Page p0334.djvu
Non-Hodgkin Lymphoma......Page p0336.djvu
Mantle Cell Lymphoma.......Page p0337.djvu
Marginal Zone Lymphoma.......Page p0338.djvu
Lymphoplasmacytic Lymphoma.......Page p0340.djvu
Differential diagnosis of small cell lymphomas......Page p0341.djvu
Burkitt Lymphoma.......Page p0345.djvu
T-cell Lymphomas.......Page p0346.djvu
Peripheral T-cell lymphoma, unspecified......Page p0347.djvu
Anaplastic large cell lymphoma......Page p0348.djvu
Post-Transplant Lymphoproliferative Disorders.......Page p0349.djvu
Differential Diagnosis of Large Cell Lymphomas......Page p0351.djvu
Malignant Melanoma......Page p0353.djvu
Seminoma or Germinoma......Page p0354.djvu
References......Page p0355.djvu
Normal Liver......Page p0359.djvu
Other Infections......Page p0361.djvu
Cirrhosis......Page p0362.djvu
Liver Cell Adenoma......Page p0363.djvu
Bile Duct Hamartoma and Adenoma......Page p0364.djvu
Angiomyolipoma......Page p0365.djvu
Hepatocellular Carcinoma......Page p0366.djvu
Cholangiocarcinoma (Bile Duct Carcinoma)......Page p0372.djvu
Epithelioid Hemangioendothelioma......Page p0374.djvu
Metastatic Tumors......Page p0375.djvu
References......Page p0380.djvu
Sampling Techniques......Page p0385.djvu
Sample Preparation and Reporting Technology......Page p0386.djvu
Cyst Fluid Analysis......Page p0387.djvu
Normal Pancreas and Bile Duct......Page p0388.djvu
Pancreatitis and Reactive Changes......Page p0389.djvu
Ductal Adenocarcinoma......Page p0390.djvu
Variants of Ductal Adenocarcinoma......Page p0392.djvu
Acinar Cell Carcinoma......Page p0393.djvu
Pancreatic Endocrine Neoplasms......Page p0394.djvu
Serous Cystadenoma......Page p0397.djvu
Mucinous Cystic Neoplasm and Intraductal Papillary Mucinous Neoplasm......Page p0398.djvu
Secondary Pancreatic Neoplasms......Page p0399.djvu
References......Page p0400.djvu
The Kidney......Page p0403.djvu
Adequacy......Page p0404.djvu
Glomeruli and Tubular Cells......Page p0405.djvu
Oncocytoma......Page p0406.djvu
Metanephric Adenoma......Page p0408.djvu
Cystic Nephroma......Page p0410.djvu
Renal Infarct......Page p0411.djvu
Renal Cysts......Page p0412.djvu
Renal Cell Carcinoma......Page p0413.djvu
Clear Cell Renal Cell Carcinoma......Page p0414.djvu
Papillary Renal Cell Carcinoma......Page p0415.djvu
Sarcomatoid Renal Cell Carcinoma......Page p0418.djvu
Translocation-Associated Renal Cell Carcinoma......Page p0419.djvu
Urothelial Carcinoma......Page p0420.djvu
Metastatic Tumors......Page p0421.djvu
The Adrenal Gland......Page p0422.djvu
Adrenal Cortical Neoplasms......Page p0423.djvu
Pheochromocytoma......Page p0425.djvu
Metastatic Tumors......Page p0426.djvu
References......Page p0427.djvu
15. Ovary......Page p0432.djvu
Accuracy......Page p0433.djvu
Cystic Follicle and Follicle Cyst......Page p0434.djvu
Endometriotic Cyst......Page p0436.djvu
Tubo-Ovarian Abscess......Page p0437.djvu
Benign Mucinous Tumors......Page p0438.djvu
Malignant Surface Epithelial-Stromal Tumors......Page p0439.djvu
Serous Borderline Tumor and Adenocarcinoma......Page p0440.djvu
Mucinous Borderline Tumor and Adenocarcinoma......Page p0441.djvu
Germ Cell Tumors......Page p0442.djvu
Mature Teratoma......Page p0443.djvu
Embryonal Carcinoma and Other Malignant Germ Cell Tumors......Page p0444.djvu
Adult Granulosa Cell Tumor......Page p0445.djvu
Juvenile Granulosa Cell Tumor......Page p0446.djvu
Metastatic Tumors......Page p0447.djvu
References......Page p0448.djvu
16. Soft Tissue......Page p0450.djvu
Ancillary Studies......Page p0451.djvu
Lipoma......Page p0453.djvu
Hibernoma......Page p0454.djvu
Spindle Cell Lipoma and Pleomorphic Lipoma......Page p0455.djvu
Well-Differentiated Liposarcoma or Atypical Lipomatous Tumor......Page p0456.djvu
Pleomorphic Liposarcoma......Page p0457.djvu
Intramuscular Myxoma......Page p0458.djvu
Myxofibrosarcoma, Low and High Grade (Myxoid Malignant Fibrous Histiocytoma)......Page p0459.djvu
Low-Grade Fibromyxoid Sarcoma......Page p0460.djvu
Myxoid or Round Cell Liposarcoma......Page p0461.djvu
Myxofibrosarcoma-Like Dedifferentiated Liposarcoma......Page p0462.djvu
Lipoblastoma......Page p0463.djvu
Chordoma......Page p0464.djvu
Leiomyosarcoma......Page p0465.djvu
Schwannoma......Page p0466.djvu
Malignant Peripheral Nerve Sheath Tumor......Page p0468.djvu
Synovial Sarcoma......Page p0469.djvu
Solitary Fibrous Tumor......Page p0471.djvu
Dermatofibrosarcoma Protuberans......Page p0473.djvu
Giant Cell Tumor of Tendon Sheath, Localized and Diffuse Types......Page p0474.djvu
Extraosseous Ewing Sarcoma/Primitive Neuroectodermal Tumor......Page p0476.djvu
Desmoplastic Small Round Cell Tumor......Page p0478.djvu
Alveolar Rhabdomyosarcoma......Page p0479.djvu
Epithelioid Sarcoma......Page p0480.djvu
Clear Cell Sarcoma (Malignant Melanoma of Soft Tissues)......Page p0481.djvu
Epithelioid Hemangioendothelioma......Page p0482.djvu
Granular Cell Tumor......Page p0483.djvu
Pleomorphic Neoplasms......Page p0484.djvu
Undifferentiated High-Grade Pleomorphic Sarcoma (Pleomorphic Malignant Fibrous Histiocytoma)......Page p0485.djvu
Idiopathic Retroperitoneal Fibrosis......Page p0486.djvu
Elastofibroma......Page p0487.djvu
References......Page p0488.djvu
Centers for Medicare and Medicaid Services......Page p0494.djvu
National Fire Protection Association......Page p0495.djvu
Laboratory Personnel......Page p0496.djvu
Cytotechnologist......Page p0497.djvu
Workflow......Page p0498.djvu
Billing......Page p0499.djvu
Procedure Codes......Page p0500.djvu
International Classification of Diseases (ICD)-9 Codes......Page p0501.djvu
Coding Pap Tests......Page p0502.djvu
The Screening (Routine) Pap Test......Page p0503.djvu
The Diagnostic Pap Test......Page p0504.djvu
Coding Nongynecologic, Non-Fine-Needle Aspiration Cases......Page p0505.djvu
Coding Fine-Needle Aspirates......Page p0506.djvu
Coding Consultation Cases......Page p0508.djvu
Retrospective Rescreen (“5-Year Lookback”)......Page p0509.djvu
Cytologic-Histologic Correlation......Page p0510.djvu
Workload Records......Page p0511.djvu
Proficiency Testing......Page p0512.djvu
Measures of Cytotechnologist Performance......Page p0513.djvu
Abnormal Rate.......Page p0514.djvu
High-Risk Human Papillomavirus-Positivity Rates for Atypical Squamous Cells of Undetermined Significance......Page p0515.djvu
Cytology/Biopsy Correlation......Page p0516.djvu
Exposure Control......Page p0517.djvu
OSHA Laboratory Standard......Page p0518.djvu
National Fire Protection Association Standard on Fire Protection for Laboratories Using Chemicals......Page p0519.djvu
References......Page p0520.djvu
A......Page p0522.djvu
B......Page p0523.djvu
C......Page p0524.djvu
E......Page p0526.djvu
F......Page p0527.djvu
H......Page p0528.djvu
L......Page p0529.djvu
M......Page p0530.djvu
P......Page p0532.djvu
R......Page p0533.djvu
S......Page p0534.djvu
T......Page p0535.djvu
Z......Page p0536.djvu
