Cushing´s syndrome is a relatively rare clinical disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function and growth impairment in children, all of which severely reduce quality of life and life expectancy. Cushing’s Syndrome: Pathophysiology, Diagnosis and Treatment reviews the difficulties in distinguishing Cushing’s syndrome from these and other common conditions, such as central obesity, menstrual irregularity and depression. It also provides state-of-the-art information on various strategies to establish the diagnosis of Cushing’s syndrome and the differential diagnosis among its diverse etiologies, as well as therapeutic approaches. Additionally, a range of conditions that represent challenges for the diagnosis and treatment--such as renal failure, pediatric age, cyclic hypercortisolism, and pregnancy--are covered in detail. A valuable resource not only for endocrinologists but also internal medicine physicians, gynecologists, pediatricians, , pituitary surgeons and urologists, Cushing’s Syndrome: Pathophysiology, Diagnosis and Treatment provides insights by experts that will help all physicians dealing with Cushing´s syndrome to expand their knowledge about the condition and provide targeted, comprehensive care.
Author(s): Margaret Castro MD, Lucila Leico Elias MD/PhD (auth.), Marcello D. Bronstein (eds.)
Series: Contemporary Endocrinology
Edition: 1
Publisher: Humana Press
Year: 2011
Language: English
Pages: 304
Tags: Endocrinology; Internal Medicine; Oncology; Pediatrics; Gynecology; Neurosurgery
Front Matter....Pages i-xi
Physiology and Pathophysiology of the HPA Axis....Pages 1-20
Etiologies of Cushing’s Syndrome....Pages 21-29
Pathogenesis of Corticotropic Tumors....Pages 31-40
Pathogenesis of Adrenocortical Tumors....Pages 41-52
Clinical Features of Cushing’s Syndrome....Pages 53-64
Laboratorial Diagnosis of Cushing’s Syndrome: Differential Diagnosis with Pseudo Cushing’s Conditions as Obesity, Alcoholism and Depression....Pages 65-78
Laboratorial Diagnosis of Cushing’s Syndrome: Differential Diagnosis Among the Different Causes of ACTH-Dependent and ACTH-Independent Cushing’s Syndrome....Pages 79-89
Imaging for the Differential Diagnosis of Cushing’s Syndrome: MRI, CT, and Isotopic Scanning....Pages 91-103
Inferior Petrosal Sampling for the Differential Diagnosis of ACTH-Dependent Cushing’s Syndrome....Pages 105-119
The Surgical Management of Cushing’s Disease....Pages 121-129
Adrenal-Directed Treatment Options for Cushing’s Disease....Pages 131-137
Radiation Therapy and Stereotactic Radiosurgery for Cushing’s Disease....Pages 139-149
Medical Management of Cushing’s Syndrome....Pages 151-162
ACTH-Dependent Cushing Syndrome: Clinical and Diagnostic Aspects, and Treatment Approaches for Ectopic Cushing’s Syndrome....Pages 163-176
Revisiting the Nelson’s Syndrome: Corticotroph Tumor Progression After Bilateral Adrenalectomy in Cushing’s Disease....Pages 177-187
ACTH-Independent Cushing’s Syndrome: Adrenocortical Tumors....Pages 189-208
ACTH-Independent Cushing’s Syndrome: Bilateral Macronodular Hyperplasia....Pages 209-224
ACTH-Independent Cushing’s Syndrome: Primary Pigmented Nodular Adrenal Disease in the Context of Carney’s Complex....Pages 225-234
Glucocorticoid Resistance....Pages 235-248
Post-operative Replacement and Assessment of HPA Axis Recovery in Cushing’s Syndrome....Pages 249-258
Special Aspects of Cushing’s Syndrome: Pregnancy....Pages 259-271
Special Aspects of Cushing’s Syndrome: Childhood....Pages 273-282
Special Aspects of Cushing’s Syndrome: Cyclic Cushing’s Syndrome....Pages 283-293
Back Matter....Pages 295-301
