The development of head and neck cancer is a multistep process in which genetic as well as epigenetic alterations interfere with the regular functions of proto-oncogenes and tumor suppressor genes. In addition, carcinogenesis is promoted by the impairment of mechanisms responsible for the maintenance of genetic stability. The accumulation of crucial events such as evasion of apoptosis, lack of senescence, deregulated proliferation, invasion and metastasis, as well as neoangiogenesis eventually determines the malignant phenotype. The 16 articles of this volume span from advances in the understanding of underlying molecular pathways (conditional mouse model, folate activity, DNA repair, genomic heterogeneity, p53 family members, human papillomavirus), to preclinical and clinical studies investigating potential novel therapeutic targets.
Author(s): Henning Bier
Series: Advances in Oto-Rhino-Laryngology
Edition: 1
Publisher: S. Karger AG (Switzerland)
Year: 2004
Language: English
Pages: 215
City: Basel ; New York
ASD ZONE.pdf......Page 1
00 Preliminary Pages.pdf......Page 2
01 Development of a Conditional Mouse Model for Head and Neck Squamous Cell Carcinoma.pdf......Page 8
02 Hypofolatemia as a Risk Factor for Head and Neck Cancer.pdf......Page 19
03 Reduced DNA Repair Capacity in Laryngeal Cancer Subjects.pdf......Page 32
04 Intratumoral Genomic Heterogeneity in Advanced Head and Neck Cancer Detected by Comparative Genomic Hybridization.pdf......Page 45
05 Function and Importance of p63 in Normal Oral Mucosa and Squamous Cell Carcinoma of the Head and Neck.pdf......Page 56
06 p53, p63 and p73 Expression in Squamous Cell Carcinomas of the Head and Neck and Their Response to Cisplatin Exposure.pdf......Page 65
07 Expression of p16 Protein Is Associated with Human Papillomavirus Status in Tonsillar Carcinomas and Has Implications on Survival.pdf......Page 79
08 EGFR-Antibody-Supplemented TPF Chemotherapy.pdf......Page 88
09 Nuclear Factor-KB as a Common Target and Activator of Oncogenes in Head and Neck Squamous Cell Carcinoma.pdf......Page 99
10 Antiangiogenic Therapy of Head and Neck Squamous Cell Carcinoma by Vascular Endothelial Growth Factor Antisense Therapy.pdf......Page 110
11 Chemokine Receptors 6 and 7 Identify a Metastatic Expression Pattern in Squamous Cell Carcinoma of the Head and Neck.pdf......Page 128
12 p53-Based Immunotherapy of Cancer.pdf......Page 141
13 p53 as an Immunotherapeutic Target in Head and Neck Cancer.pdf......Page 158
14 Imbalance in Absolute Counts of T Lymphocyte Subsets in Patients with Head and Neck Cancer and Its Relation to Disease1.pdf......Page 168
15 Antitumor Immunization of Head and Neck Squamous Cell Carcinoma Patients with a Virus-Modified Autologous Tumor Cell Vaccine.pdf......Page 180
16 Prognostic Factors.pdf......Page 191
17 Author index.pdf......Page 208
18 Subject Index.pdf......Page 209
