This book presents a collection of chapters on Covid-19 topics, with focus on the metabolomics and diagnosis. The chapters report on diagnostic tests for detection of SARC-CoV-2 virus and related proteins as well as post-Covid omics. This book covers Fourier-Transform Infrared spectroscopy and spectromicroscopy applied to Covid-19 studies and Carbon Nanomaterials as Covid-19 Electrochemical sensors. Moreover, the reader will find content on 3D printing for virus diagnosis, as well as organ-on-a-chip models for viral infection proteomics interaction.
Author(s): Frank N. Crespilho
Publisher: Springer
Year: 2023
Language: English
Pages: 158
City: Cham
Contents
Fourier-Transform Infrared Spectroscopy and Spectromicroscopy Studies for Diagnosis of Covid-19 Infection
1 Introduction
2 Principles of Infrared Spectroscopy and Spectromicroscopy
3 FTIR for COVID-19 Studies
4 Summary
References
Point-of-Care Devices with Electrochemical Detection for COVID-19 Diagnosis
1 Point-of-Care Devices
2 Electrochemical Devices for SARS-CoV-2
3 Point-of-Care Electrochemical Devices for SARS-CoV-2 Detection
4 Conclusion and Future Perspectives
References
Carbon Nanomaterials for Electrochemical Detection of SARS-CoV-2 Infections
1 Introduction
2 Carbon Nanomaterials: Types and Classification
2.1 Carbon Nanotubes
2.2 Graphene
3 Carbon Nanomaterials in Sensing
4 COVID-19
4.1 CNMS for SARS-Cov-2 Antigen Detection
4.2 Field Effect Transistors
5 Conclusion
References
Use of Metallic Nanostructures in Electrochemical Biosensing of SARS-CoV-2
1 Introduction
2 Electrochemical Determination of SARS-CoV-2 with Metallic Nanostructures
3 Conclusions and Perspectives
References
3D Printing for Virus Diagnosis
1 Viral Disease and Pandemics: A Brief Contextualization
2 3D Printing Technology
3 3D Printed as a New Tool in the Combat of Viral Diseases
3.1 3D Printed Accessories
3.2 3D Printing of Nasopharyngeal Swabs
3.3 RT-PCR
3.4 ELISA
4 Electrochemical 3D Printed Biosensors
4.1 Immunosensors
4.2 Genosensor
4.3 Aptasensor
5 Conclusion and Future Perspectives
References
Post-COVID-19 Metabolomics: Pursuing the Sequels of a Pandemic
1 Introduction
2 Biochemistry of COVID-19 Infection
2.1 Viral Entry and Replication
2.2 Physiopathology and Disease Progression
2.3 COVID-19 Infection Outside of Lungs
3 Post COVID-19 Syndrome
3.1 Post Severe COVID-19 Syndrome
3.2 Post-Mild COVID-19 Syndrome
3.3 Occurrence and Distribution of Symptoms Across Age, Race, and Sex
4 Metabolic Changes During and Post COVID-19 Infection
4.1 Plasma Metabolome Changes During COVID-19
4.2 Persistent Metabolic Changes in Post COVID-19 Syndrome
References
Metabolic Behavior of Covid-19 Infection Severity
1 Introduction
2 SARS-CoV-2 Infection: What You Need to Know
3 Covid-19 Severity-Related Factors
4 “Omic” Signature: An Analytical Perspective of Severity Markers
5 Conclusion
References
“Pandemics-on-a-Chip”: Organ-on-a-Chip Models for Studying Viral Infections
1 Introduction
2 Organ-on-Chip in the Pandemic Scenario
2.1 Microbiological Challenges for Viral Disease Research in OoC
2.2 Biofabrication of Organs-on-a-Chip for Viral Disease
3 The Study of Viral Infectious Diseases Using Organ-on-a-Chip
3.1 Gut-on-a-Chip
3.2 Lung-on-a-Chip
3.3 Kidney-on-a-Chip
3.4 Liver-on-a-Chip
4 Analytical Techniques Applied in Organ-on-a-Chip Models
4.1 Detection Methods Adapted to OoC
4.2 Methods Applied to Viruses Studies on OoC
5 Conclusions and Future Perspectives
References
