Cortico-subcortical dynamics in Parkinson’s disease aims to integrate key pathophysiological aspects underlying Parkinson’s disease. The volume offers a broad spectrum of opinions on how chronic dopamine depletion affects cortico-subcortical dynamics, especially how disruptions of the non-dopaminergic systems resulting from chronic dopaminergic degeneration could lead to the functional alterations observed in parkinsonism.
About the Editor:
Dr. Kuei Y. Tseng is Assistant Professor in the Department of Cellular and Molecular Pharmacology at Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL, USA.
Author(s): Shannon R. Blume, Kuei Y. Tseng (auth.), Kuei-Yuan Tseng (eds.)
Series: Contemporary Neuroscience
Edition: 1
Publisher: Humana Press
Year: 2009
Language: English
Pages: 316
Tags: Neurosciences; Human Physiology; Neurology; Pharmacology/Toxicology; Neurobiology
Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Leading Toward a Unified Cortico-basal Ganglia Functional Model....Pages 1-20
Modeling Parkinson’s Disease: 50 Years Later....Pages 23-34
Front Matter....Pages 1-1
Phasic Dopaminergic Signaling: Implications for Parkinson’s Disease....Pages 37-54
Striatal Dendritic Adaptations in Parkinson’s Disease Models....Pages 55-71
Diversity of Up-State Voltage Transitions During Different Network States....Pages 73-85
The Corticostriatal Pathway in Parkinson’s Disease....Pages 87-104
Cholinergic Interneuron and Parkinsonism....Pages 105-115
Basal Ganglia Network Synchronization in Animal Models of Parkinson’s Disease....Pages 117-142
Converging into a Unified Model of Parkinson’s Disease Pathophysiology....Pages 143-156
The Corticostriatal Transmission in Parkinsonian Animals: In Vivo Studies....Pages 157-169
Striatal Nitric Oxide–cGMP Signaling in an Animal Model of Parkinson’s Disease....Pages 171-184
Dopamine–Endocannabinoid Interactions in Parkinson’s Disease....Pages 185-205
Glutamate Plasticity in an Animal Model of Parkinson’s Disease....Pages 207-230
Front Matter....Pages 1-1
Neuromodulation and Neurodynamics of Striatal Inhibitory Networks: Implications for Parkinson’s Disease....Pages 233-243
Dopaminergic Modulation of Corticostriatal Interactions and Implications for Parkinson’s Disease....Pages 245-258
Front Matter....Pages 1-1
Pathogenesis of Oxidative Stress and the Destructive Cycle in the Substantia Nigra in Parkinson’s Disease....Pages 261-271
Regulation of G-Protein-Coupled Receptor (GPCR) Trafficking in the Striatum in Parkinson’s Disease....Pages 273-281
Atypical Parkinsonism in the French West Indies: The Plant Toxin Annonacin as a Potential Etiological Factor....Pages 283-290
Cognitive Deficits in Parkinson’s Disease....Pages 291-305
Front Matter....Pages 1-1
Dopamine Replacement Therapy in Parkinson’s Disease: Past, Present and Future....Pages 309-334
Front Matter....Pages 1-1
Molecular, Cellular and Electrophysiological Changes Triggered by High-Frequency Stimulation of the Subthalamic Nucleus in Animal Models of Parkinson’s Disease....Pages 335-370
Surgical Strategies for Parkinson’s Disease Based on Animal Model Data: GPi and STN Inactivation on Various Aspects of Behavior (Motor, Cognitive and Motivational Processes) ....Pages 371-391
Antidromic Cortical Activity as the Source of Therapeutic Actions of Deep Brain Stimulation....Pages 393-403
Cell-Based Replacement Therapies for Parkinson’s Disease....Pages 405-431
Back Matter....Pages 433-449
