To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system.Chapters in this book deal specifically with cell fate determination, cell migration and disorders of cell migration; current concepts and new ideas about cortical arealisation, and disorders which can arise from incorrect arealisation; genes implicated in the development of cortical connectivity and related pathologies such as schizophrenia and synaesthesia; and susceptibility genes for cognitive disorders such as schizophrenia, autism, dyslexia, and attention deficit disorder.
Author(s): Novartis Foundation
Edition: 1
Year: 2008
Language: English
Pages: 302
CORTICAL DEVELOPMENT: GENES AND GENETIC ABNORMALITIES......Page 2
Contents......Page 8
Chair’s introduction......Page 16
Molecular development of corticospinal motor neuron circuitry......Page 18
DISCUSSION......Page 30
Perspectives on the developmental origins of cortical interneuron diversity......Page 36
DISCUSSION......Page 50
Genetic determinants of neuronal migration in the cerebral cortex......Page 60
DISCUSSION......Page 68
Neural stem and progenitor cells in cortical development......Page 74
DISCUSSION......Page 88
Genes that control the size of the cerebral cortex......Page 94
DISCUSSION......Page 106
General Discussion I......Page 111
Control of cortical neuron layering: lessons from mouse chimeras......Page 114
DISCUSSION......Page 123
Intracortical multidirectional migration of cortical interneurons......Page 131
DISCUSSION......Page 140
The atypical cadherin Celsr3 regulates the development of the axonal blueprint......Page 145
DISCUSSION......Page 149
Regulation of laminar and area patterning of mammalian neocortex and behavioural implications......Page 156
DISCUSSION......Page 174
Genetic regulation of prefrontal cortex development and function......Page 180
DISCUSSION......Page 188
Self-organization and pattern formation in primate cortical networks......Page 193
DISCUSSION......Page 210
Molecular mechanisms of thalamocortical axon targeting......Page 214
DISCUSSION......Page 223
Genes involved in the formation of the earliest cortical circuits......Page 227
DISCUSSION......Page 239
Emx and Nfi genes regulate cortical development and axon guidance in the telencephalon......Page 245
DISCUSSION......Page 257
Schizophrenia susceptibility genes and their neurodevelopmental implications: focus on neuregulin 1......Page 261
DISCUSSION......Page 270
Focal brain malformations: a spectrum of disorders along the mTOR cascade......Page 275
DISCUSSION......Page 287
Final Discussion......Page 291
Contributor Index......Page 297
Subject Index......Page 299
