To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system.
Chapters in this book deal specifically with cell fate determination, cell migration and disorders of cell migration; current concepts and new ideas about cortical arealisation, and disorders which can arise from incorrect arealisation; genes implicated in the development of cortical connectivity and related pathologies such as schizophrenia and synaesthesia; and susceptibility genes for cognitive disorders such as schizophrenia, autism, dyslexia, and attention deficit disorder.
Author(s): Novartis Foundation
Series: Novartis Foundation Symposia
Edition: 1
Publisher: Wiley-Interscience
Year: 2008
Language: English
Pages: 303
CORTICAL DEVELOPMENT: GENES AND GENETIC ABNORMALITIES......Page 1
Contents......Page 7
Chair’s introduction......Page 15
Molecular development of corticospinal motor neuron circuitry......Page 17
DISCUSSION......Page 29
Perspectives on the developmental origins of cortical interneuron diversity......Page 35
DISCUSSION......Page 49
Genetic determinants of neuronal migration in the cerebral cortex......Page 59
DISCUSSION......Page 67
Neural stem and progenitor cells in cortical development......Page 73
DISCUSSION......Page 87
Genes that control the size of the cerebral cortex......Page 93
DISCUSSION......Page 105
General Discussion I......Page 110
Control of cortical neuron layering: lessons from mouse chimeras......Page 113
DISCUSSION......Page 122
Intracortical multidirectional migration of cortical interneurons......Page 130
DISCUSSION......Page 139
The atypical cadherin Celsr3 regulates the development of the axonal blueprint......Page 144
DISCUSSION......Page 148
Regulation of laminar and area patterning of mammalian neocortex and behavioural implications......Page 155
DISCUSSION......Page 173
Genetic regulation of prefrontal cortex development and function......Page 179
DISCUSSION......Page 187
Self-organization and pattern formation in primate cortical networks......Page 192
DISCUSSION......Page 209
Molecular mechanisms of thalamocortical axon targeting......Page 213
DISCUSSION......Page 222
Genes involved in the formation of the earliest cortical circuits......Page 226
DISCUSSION......Page 238
Emx and Nfi genes regulate cortical development and axon guidance in the telencephalon......Page 244
DISCUSSION......Page 256
Schizophrenia susceptibility genes and their neurodevelopmental implications: focus on neuregulin 1......Page 260
DISCUSSION......Page 269
Focal brain malformations: a spectrum of disorders along the mTOR cascade......Page 274
DISCUSSION......Page 286
Final Discussion......Page 290
Contributor Index......Page 296
Subject Index......Page 298
