Under the auspices of the 12th International Symposium on Special Aspects in Radiotherapy 2008 in Berlin, acknowledged experts presented their perspectives on small and non-small cell lung cancer, reflecting the latest standards and engaging in controversies in the diagnosis and treatment of this disease. In the first part of this volume, aspects of the diagnostic workup are highlighted from the histopathologist's point of view, followed by presentations concerning the value of PET-CT and whole-body MRI in the staging of lung cancer. The use and current methods in bronchoscopy, endoscopic ultrasound, video-endoscopy and mediastinoscopy are discussed in detail. The second section presents surgical and radio-oncological treatment concepts for stage I/II non-small cell lung cancer including stereotactic radiotherapy. The third section outlines the curative options for stage III NSCLC: extended surgical approaches, definitive radiochemotherapy and current concepts in adjuvant therapies. Emphasis is also placed on altered fractionation schemes in radiotherapy. Section 4 is dedicated to palliative procedures and the last section gives an in-depth presentation of small cell lung cancer. This book provides an excellent overview of up-to-date standards and future strategies in lung cancer treatment. It will be of great value to surgeons, radiation oncologists, pulmonary specialists and other clinicians interested in this disease.
Author(s): J. Heide, A. Schmittel, D. Kaiser, W. Hinkelbein
Edition: 1
Year: 2009
Language: English
Pages: 211
Contents......Page 6
Abstract......Page 8
Small Cell Lung Cancer......Page 10
Prognosis and Predictive Factors in Small Cell Lung Cancer......Page 11
Squamous Cell Carcinoma Histological Subtypes Associated with Poor Prognosis......Page 12
Bronchioloalveolar Cell Carcinoma Growth Pattern: A Favorable Prognostic Factor......Page 13
Large Cell Carcinomas......Page 14
Prognostic Implication of Molecular Markers......Page 15
Conclusion......Page 19
References......Page 20
Abstract......Page 22
Non-Small Cell Lung Cancer......Page 23
Staging of Lung Cancer – Distant Metastases......Page 32
Prediction and Monitoring Response to Therapy......Page 40
Pleural Metastases......Page 42
Cost-Effectiveness......Page 43
References......Page 44
Abstract......Page 53
Staging of Lung Cancer Using Whole-Body MRI......Page 54
References......Page 60
Abstract......Page 62
EBUS-TBNA: Technique......Page 63
Clinical Results......Page 65
Conclusion......Page 67
References......Page 68
Abstract......Page 70
Results......Page 71
Comments......Page 74
Implications for Clinical Practice and Further Research......Page 76
References......Page 77
Abstract......Page 78
Surgery in Stages I and II......Page 79
References......Page 82
Abstract......Page 85
Surgical Technique of Systematic Lymph Node Dissection......Page 86
Impact of Mediastinal Lymph Node Dissection on Operative Morbidity, Mortality and Quality of Life......Page 88
Diagnostic Role of Mediastinal Lymph Node Dissection......Page 89
Therapeutic Role of Mediastinal Lymph Node Dissection......Page 90
References......Page 91
Abstract......Page 94
Radiation Therapy alone in Early Non-Small Cell Lung Cancer......Page 95
Avenues for an Improvement of RT Alone in Early NSCLC......Page 98
References......Page 99
Abstract......Page 101
Definitions of Stereotactic Body Radiation Therapy......Page 102
Staging Procedures before SBRT......Page 104
Implementation of Techniques in Clinical Routine......Page 105
Biological Basis of Hypofractionated SBRT......Page 108
Clinical Experience......Page 109
Follow-Up Recommendations......Page 116
References......Page 117
Abstract......Page 122
Discussion of Stage-Related Treatment......Page 123
References......Page 127
Abstract......Page 129
Optimization of Combined Radiotherapy and Chemotherapy......Page 130
Which Chemotherapy and Radiotherapy Regimens Are Optimal for Concurrent Chemoradiotherapy?......Page 133
How Do Comorbidities Influence the Performance of Concurrent Chemoradiotherapy?......Page 137
References......Page 139
Abstract......Page 142
Landmark Studies Concerning Adjuvant Platinum-Based Chemotherapy......Page 143
The LACE (Lung Adjuvant Cisplatin Evaluation) Meta-Analysis (table 2)......Page 144
Adjuvant Chemotherapy and Stage (table 3)......Page 145
Patient Selection and Predictive or Prognostic Factors......Page 147
Conclusion......Page 149
References......Page 150
Abstract......Page 152
References......Page 155
Abstract......Page 157
Hypofractionated Stereotactic Body Radiotherapy for NSCLC (Stage I)......Page 158
Hyperfractionated Accelerated Radiotherapy for Stage III NSCLC......Page 161
References......Page 162
Abstract......Page 164
Cisplatin- vs. Carboplatin-Based Chemotherapy......Page 165
Customized Chemotherapy......Page 166
Maintenance Therapy......Page 167
Assessment of Efficacy......Page 168
References......Page 169
Clinical Manifestations of Advanced Lung Carcinoma......Page 171
Palliative Potential of Radiotherapy......Page 172
Treatment Strategies......Page 174
References......Page 178
Abstract......Page 180
Thoracic Radiotherapy......Page 181
Patient Selection......Page 184
References......Page 185
Abstract......Page 187
RT in ED-SCLC Trial......Page 188
Future Approaches......Page 191
References......Page 192
Introduction......Page 194
Prophylactic Cranial Irradiation......Page 195
Thoracic Radiotherapy......Page 197
References......Page 198
First-Line Chemotherapy......Page 200
Second-Line Chemotherapy......Page 202
References......Page 203
Abstract......Page 205
Methods......Page 207
Results......Page 208
Discussion......Page 209
Conclusions......Page 210
References......Page 211
Author Index......Page 213
Subject Index......Page 214
