This book describes control of ventilation during sleep in both health and disease states. The topics are presented in a fashion that can be easily comprehended with many figures to illustrate complex concepts. Thus, a wide range of topics, starting from the site of normal respiratory rhythm generation to chemoreceptor control of sleep apnea, description of the apneic threshold, pathophysiology of upper airway closure, novel techniques to measure control of breathing, effect of cerebral blood flow on breathing, effect of opioids on ventilation, effect of heart failure on ventilation, genetic aspects of breathing disorders, age and gender differences, and various therapies are discussed.
Key Features
• Helps to bridge the gap between straight forward physiology and clinical practice through a range of topics and use of case vignettes
• Explores various aspects of clinical management and control which is beneficial to sleep clinicians, respiratory physiologists, intensivists, trainees, and researchers.
• Distills complex concepts into understandable language and figures, providing helping resource to the clinicians, that transforms a dry topic vis a viz control of ventilation into an exciting understandable ‘clinician’ language.
Author(s): Susmita Chowdhuri, M. Safwan Badr, James A. Rowley
Publisher: CRC Press
Year: 2022
Language: English
Pages: 281
City: Boca Raton
Cover
Half Title
Title Page
Copyright Page
Dedication
Table of Contents
Foreword
Preface
About the Editors
List of Contributors
Section I: Anatomy, Development, Aging, and Mechanisms of Control of Ventilation
1. Anatomy of the Respiratory Neural Network
2. Chemoreception: Pathways, Plasticity, and Pathophysiology
3. Developmental Changes in the Respiratory System of the Neonate-Child
4. Control of Breathing in Older Adults
5. Breathing Control in Exercise
6. Control of the Upper Airway during Sleep
Section II: Pathophysiology of Sleep-Disordered Breathing
7. Pathophysiology of Sleep-Disordered Breathing in Children and Neonates
8. Pathogenesis of Sleep-Disordered Breathing in Adults: Overview
9. Risk and Causality by Genetics, Gender, and Age
10. The Influence of Cerebral Blood Flow and Cerebrovascular Responsiveness on Ventilatory Control
11. Central Apnea: Propensity and Plasticity
Section III: Sleep-Disordered Breathing in Different Conditions and Disease States
12. Sleep-Disordered Breathing due to Heart Failure
13. Breathing at Altitude
14. Sleep-Disordered Breathing Associated with Chronic Lung Diseases
15. Obesity Hypoventilation Syndrome
Section IV: Pathophysiology-Directed Therapies for Sleep-Disordered Breathing
16. Effect of Positive Airway Pressure on Ventilatory Control and Sleep-Disordered Breathing
17. Mild Intermittent Hypoxia and Supplemental Oxygen: Potential Therapeutic Interventions to Treat Breathing Instability
18. Pharmacological Management of Sleep-Disordered Breathing
19. Neural Mechanisms Regulating Opioid-Induced Respiratory Depression and Therapeutic Strategies to Alleviate the Respiratory Side-Effects of Opioid Drugs
20. Pharmacologic Intervention Studies to Mitigate Breathing Instability – Animal Studies
Index
