connective tissues are essential for the physical functioning of the animals's body. The condition of the various connective tissues is governed by biochemical factors, anabolism and catabolism, that are controlled by specific enzymes. Any change outside the normal range of metabolism, for instance induced by immunological reactions, may induce a pathological disturbance. The result can be acute or chronic inflammation, or loss of normal function, expressed in loosening, dilatation, breaking, wear, stiffness, shrinking, scars, stenosis, and cirrhosis or any other kind of fibrosis. A first step toward improving our understanding of the feedback mecha nism that maintains the biological status and texture of a given connective tissue is to combine what is known about synthesis and enzymatic degradation of the components of fibers and ground substance. Common pathological phenomena like chronic inflammation of immune reactions can be either the result of the cause of disturbances in the sensitive balance of connective tissue metabolism. Nowadays con nective tissues are less and less regarded as brady trophic tissue but rather as a stimulating and many-sided problem of research. Before we can understand the pathogenesis of the connective tissue diseases that result in the destructive processes mentioned above, basic research will be necessary. This research will be furthered by a constant exchange of information and the results of· observations. To promote this exchange of information between scientists, symposia on connective tissue research are organized at regular intervals.
Author(s): E. Buddecke, H. Kresse, G. Segeth, K. V. Figura (auth.), Professor Dr. Reinhard Fricke, Professor Dr. Fritz Hartmann (eds.)
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 1974
Language: English
Pages: 312
Tags: Medicine/Public Health, general; Biomedicine general; Life Sciences, general
Front Matter....Pages I-XII
Front Matter....Pages 1-1
Metabolic Heterogeneity of Acidic Glycosaminoglycans in Bovine Arterial Tissue....Pages 3-6
Chemical and Molecular Heterogeneity of Cartilage Proteoglycans....Pages 7-15
Proteochondroitin Sulfates, Chemical and Metabolic Heterogeneity, Immunology and Biosynthesis....Pages 16-36
Isolation of Corneal Keratan-Chondroproteoglycans and Their Composition....Pages 37-49
Glycopeptide Pattern of the Polymeric Macromolecular Complex of the Stroma Layers and of the Endothelial Basement Membrane (Descemet’s Membrane) of the Embryonic and Postnatal Calf Cornea....Pages 50-54
The Chemistry of Glycoproteins at the Surfaces of Tumor Cells....Pages 55-60
The Relationship between Chemical Structure and Fibrogenic Character of Glycosaminoglycans....Pages 61-63
Periodate Sensitivity of Cross-Links of Mature Collagen....Pages 64-66
Variations in the Diameter of Collagen Fibrils, Bound Hexose and Associated Glycoproteins in the Intervertebral Disc....Pages 67-70
Front Matter....Pages 71-71
Biosynthesis of Connective Tissue Proteoglycans....Pages 73-84
Synthesis of Sulfated Glycosaminoglycans by Cultured Cells, with Particular Reference to the Mouse Fibroblast Line 3T6....Pages 85-88
The Subcellular Site of the Biosynthesis of N-Glycoloyl- and N-Acetyl-O-Acetylneuraminic Acid Components of Porcine, Bovine and Equine Submaxillary Gland Glycoproteins....Pages 89-101
N-Acetyl-Hydroxylation in the Biosynthesis of Glycoproteins....Pages 102-106
Biosynthesis of Collagen....Pages 107-121
Studies on Collagen Synthesis Applying Labelled Proline....Pages 122-128
Front Matter....Pages 129-129
Mammalian Enzymes Degrading Glycosaminoglycans....Pages 131-145
The Production and Use of Water-Insoluble Derivatives of Enzymes....Pages 146-149
The Enzymatic Degradation of Proteoglycans....Pages 150-157
Lysosomal Enzymes and Proteoglycan Degradation in the Human Intervertebral Disc....Pages 158-165
Studies on Lysosomal Proteoglycan Degradation....Pages 166-172
Front Matter....Pages 129-129
Action of Mammalian Collagenases....Pages 173-176
The Mechanism of Collagen Decomposition in Mammals....Pages 177-179
Studies on Collagen Peptidases....Pages 180-190
Degradation of Insoluble Collagen and other Proteins by Rat Leucocytes....Pages 191-192
Enzymatic Degradation of the “Collagen-Like-Protein” in Blood Serum....Pages 193-195
Sequential Degradation and Phagocytosis of Heterologous Elastin....Pages 196-198
Front Matter....Pages 199-199
Immunobiology of Glycoproteins....Pages 201-220
Immunological Properties of Ovine Submaxillary Glycoproteins....Pages 221-224
The Distribution of Antigenic Determinants in Collagen as Determined by a Radioimmunoassay....Pages 225-231
Antigenicity of Soluble Collagen Fractions of Different Species....Pages 232-234
Front Matter....Pages 235-235
Questions of Medicine to Molecular Biology of Connective Tissues....Pages 237-239
Structural Glycoproteins of Connective Tissue: Their Role in Morphogenesis and Immunopathology....Pages 240-256
Experimental Chronic Arthritis in Pigs after a Single Intraarticular Injection of Heterologous Proteoglycans....Pages 257-260
Hyaluronidase Activity in Lysosomes and Extracellular Fluid of TumorCells....Pages 261-261
Clinical and Experimental Investigations of the Metabolism of Collagen, Ground Substance, and Mesenchymal Cells....Pages 262-272
Collagen Maturation in Granulation Tissue....Pages 273-277
A Negative Role for Collagenase in Observed Differences between Human Normal and Rheumatoid Polymeric Collagens....Pages 278-280
The Possible Role of Cross-Linking of Collagen in Rheumatoid Arthritis....Pages 281-287
Studies on Collagen Biosynthesis in Rheumatoid Synovial Tissue....Pages 288-289
Changes in Skin Collagen in Osteoporosis....Pages 290-299
Front Matter....Pages 235-235
Collagen and Elastin Metabolism in Scurvy: Studies on the Nature of the Collagen Lesion....Pages 300-303
Back Matter....Pages 305-309
