The definitive pocket reference for convenient everyday use. This invaluable clinical companion begins with an overview of the general principles relevant to the safe and effective use of psychotropic medications. Subsequent chapters focus on the major classes of psychotropic medications and the disorders for which they are prescribed—with the caveat that the nomenclature is somewhat artificial because, for example, many antidepressant medications are also used to treat anxiety disorders. Updates for this edition in every drug class ensure ready access to information on new drugs and new findings.
- Antidepressants—Presents clinically relevant information for selective serotonin reuptake inhibitors, bupropion, venlafaxine, duloxetine, mirtazapine, as well as tricyclic antidepressants and monoamine oxidase inhibitors, including details on choosing one antidepressant over another and discontinuing or switching medications. Updated with new information on the possible risk of increased suicidality and other potential side effects.
- Anxiolytics, sedatives, and hypnotics—Discusses the use of benzodiazepines, zolpidem, and zaleplon, and ramelteon for the treatment of insomnia as well as diagnosis-specific guidelines for the use of antidepressants in the treatment of anxiety disorders.
- Antipsychotics—Describes the properties common to most antipsychotics, focusing on atypical antipsychotics (clozapine, risperidone, olanzapine, quetiapine, ziprasidone), now used as first-line agents. New in this edition: the latest findings on safety and efficacy, and on the use of antipsychotic agents in bipolar disorder.
- Mood stabilizers—-Details the use of lithium, valproate, carbamazepine, lamotrigine, and other anticonvulsants in stabilizing mood oscillations, and expands on the use of antipsychotics for treating bipolar disorder. With new information on the treatment of mania and mixed episodes.
- Stimulants—Covers the clinical use, contraindications, risks and side effects, dosing strategies, and monitoring guidelines for methylphenidate hydrochloride, dextroamphetamine, pemoline, and modafinil, used to treat attention-deficit/hyperactivity disorder in children and adolescents, narcolepsy, and (potentially) treatment-resistant depression and cognitive impairment in adults.
- Cognitive enhancers—Discusses the clinical use, drug interactions, and side effects of the cholinesterase inhibitors tacrine, donepezil, rivastigmine, and galantamine, which preserve functioning and slow further deterioration in the pharmacological management of cognitive impairment in mild-to-moderate dementia of the Alzheimer's type. Fully updated to reflect the latest findings on the NMDA receptor antagonist memantine.
Packed with practical information that is easy to access via detailed tables and charts, this pocket-sized volume (it literally fits into a lab coat or jacket pocket) is designed to be immediately useful for students, residents, and clinicians working in a variety of treatment settings, such as inpatient psychiatry units, outpatient clinics, consultation-liaison services, and private offices.
Author(s): Lauren B. Marangell, James M. Martinez
Series: Concise Guides
Edition: 2
Publisher: American Psychiatric Publishing
Year: 2006
Language: English
Pages: 260
1585622559......Page 1
Contents......Page 6
About the Authors......Page 18
Introduction to the Concise Guides Series......Page 20
Acknowledgments......Page 22
Initial Evaluation......Page 24
Use of Multiple Medications......Page 25
Generic Substitution......Page 26
Cytochrome P450 Enzymes......Page 27
Protein Binding......Page 31
References......Page 32
Indications and Efficacy......Page 34
Clinical Use......Page 35
Selective Serotonin Reuptake Inhibitors......Page 44
Clinical Use......Page 45
Risks, Side Effects, and Their Management......Page 47
Drug Interactions......Page 52
Venlafaxine......Page 53
Duloxetine......Page 55
Bupropion......Page 57
Risks, Side Effects, and Their Management......Page 58
Overdose......Page 59
Drug Interactions......Page 60
Overdose......Page 61
Risks, Side Effects, and Their Management......Page 62
Overdose......Page 63
Tricyclic and Heterocyclic Antidepressants......Page 64
Clinical Use......Page 65
Risks, Side Effects, and Their Management......Page 66
Overdose......Page 68
Monoamine Oxidase Inhibitors......Page 69
Clinical Use......Page 70
Risks, Side Effects, and Their Management......Page 76
Acute Major Depression......Page 79
Bipolar Depression......Page 80
Maintenance Treatment of Major Depression......Page 81
Treatment-Resistant Depression......Page 82
Discontinuation of Antidepressants......Page 84
Antidepressant Switching......Page 85
References......Page 87
3 Anxiolytics, Sedatives, and Hypnotics......Page 92
Indications and Efficacy......Page 93
Risks, Side Effects, and Their Management......Page 95
Use in Pregnancy......Page 97
Clinical Use......Page 98
Zolpidem and Zaleplon......Page 99
Overdose......Page 100
Clinical Use......Page 101
Indications and Efficacy......Page 102
Generalized Anxiety Disorder......Page 103
Panic Disorder......Page 106
Performance Anxiety......Page 107
Insomnia......Page 108
Agitation and Aggression......Page 109
References......Page 112
4 Antipsychotics......Page 114
Indications and Efficacy......Page 117
Risks, Side Effects, and Their Management......Page 118
Extrapyramidal Side Effects......Page 120
Adrenergic Side Effects......Page 125
Endocrine Effects and Sexual Side Effects......Page 126
Ocular Effects......Page 127
Hematological Effects......Page 128
Drug Interactions......Page 129
Atypical Antipsychotics......Page 131
Aripiprazole......Page 132
Clozapine......Page 133
Risperidone......Page 138
Olanzapine......Page 140
Quetiapine......Page 142
Ziprasidone......Page 144
Conventional Antipsychotics......Page 146
Long-Acting Injectable Antipsychotics......Page 147
General Principles......Page 148
Treatment-Resistant Schizophrenia......Page 149
References......Page 150
Mechanism of Action......Page 158
Clinical Use......Page 159
Contraindications and Pretreatment Medical Evaluation......Page 160
Risks, Side Effects, and Their Management......Page 165
Overdose and Toxicity......Page 167
Mechanism of Action......Page 168
Clinical Use......Page 170
Risks, Side Effects, and Their Management......Page 172
Drug Interactions......Page 174
Clinical Use......Page 175
Risks, Side Effects, and Their Management......Page 176
Lamotrigine......Page 178
Clinical Use......Page 179
Drug Interactions......Page 180
Oxcarbazepine......Page 181
Atypical Antipsychotics......Page 182
Olanzapine-Fluoxetine Combination......Page 183
Treatment of Mania or Mixed Episodes......Page 185
Treatment of Bipolar Depression......Page 186
Maintenance Treatment in Bipolar Disorder......Page 187
References......Page 188
Mechanisms of Action......Page 194
Contraindications......Page 196
Abuse......Page 197
Dosing......Page 198
Methylphenidate......Page 201
Dextroamphetamine......Page 209
Pemoline......Page 210
Modafinil......Page 211
Attention-Deficit/Hyperactivity Disorder......Page 212
Atomoxetine......Page 213
References......Page 216
Mechanisms of Action......Page 224
Clinical Use......Page 227
Donepezil......Page 229
Rivastigmine......Page 231
Galantamine......Page 232
Tacrine......Page 233
Memantine......Page 234
References......Page 236
Appendix: Trade/Brand Names of Common Psychiatric Drugs......Page 244
A......Page 250
B......Page 251
C......Page 252
D......Page 253
E......Page 254
I......Page 255
M......Page 256
O......Page 257
R......Page 258
S......Page 259
T......Page 260
Z......Page 261
