This book constitutes the refereed proceedings of the Second International Symposium on Computational Life Sciences, CompLife 2006, held in Cambridge, UK, in September 2006.
The 25 revised full papers presented were carefully reviewed and selected from 56 initial submissions. The papers are organized in topical sections on genomics, data mining, molecular simulation, molecular informatics, systems biology, biological networks/metabolism, and computational neuroscience.
Author(s): Michael Hirsch, Allan Tucker, Stephen Swift, Nigel Martin, Christine Orengo (auth.), Michael R. Berthold, Robert C. Glen, Ingrid Fischer (eds.)
Series: Lecture Notes in Computer Science 4216 : Lecture Notes in Bioinformatics
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2006
Language: English
Pages: 269
Tags: Information Storage and Retrieval; Health Informatics; Database Management; Information Systems Applications (incl.Internet); Bioinformatics; Proteomics
Front Matter....Pages -
Improved Robustness in Time Series Analysis of Gene Expression Data by Polynomial Model Based Clustering....Pages 1-10
A Hybrid Grid and Its Application to Orthologous Groups Clustering....Pages 11-20
Promoter Prediction Using Physico-Chemical Properties of DNA....Pages 21-31
Parametric Spectral Analysis of Malaria Gene Expression Time Series Data....Pages 32-41
An Efficient Algorithm for Finding Long Conserved Regions Between Genes....Pages 42-51
The Reversal Median Problem, Common Intervals, and Mitochondrial Gene Orders....Pages 52-63
Building Structure-Property Predictive Models Using Data Assimilation....Pages 64-73
Set-Oriented Dimension Reduction: Localizing Principal Component Analysis Via Hidden Markov Models....Pages 74-85
Relational Subgroup Discovery for Descriptive Analysis of Microarray Data....Pages 86-96
Applicability of Loop Recombination in Ciliates Using the Breakpoint Graph....Pages 97-106
High-Throughput Identification of Chemistry in Life Science Texts....Pages 107-118
Beating the Noise: New Statistical Methods for Detecting Signals in MALDI-TOF Spectra Below Noise Level....Pages 119-128
Dynamic Complexity of Chaotic Transitions in High-Dimensional Classical Dynamics: Leu-Enkephalin Folding....Pages 129-140
Solvent Effects and Conformational Stability of a Tripeptide....Pages 141-149
Grid Assisted Ensemble Molecular Dynamics Simulations of HIV-1 Proteases Reveal Novel Conformations of the Inhibitor Saquinavir....Pages 150-161
A Structure-Based Analysis of Single Molecule Force Spectroscopy (SMFS) Data for Bacteriorhodopsin and Four Mutants....Pages 162-172
Classifying the World Anti-Doping Agency’s 2005 Prohibited List Using the Chemistry Development Kit Fingerprint....Pages 173-182
A Point-Matching Based Algorithm for 3D Surface Alignment of Drug-Sized Molecules....Pages 183-193
Adaptive Approach for Modelling Variability in Pharmacokinetics....Pages 194-204
A New Approach to Flux Coupling Analysis of Metabolic Networks....Pages 205-215
Software Supported Modelling in Pharmacokinetics....Pages 216-225
On the Interpretation of High Throughput MS Based Metabolomics Fingerprints with Random Forest....Pages 226-235
Construction of Correlation Networks with Explicit Time-Slices Using Time-Lagged, Variable Interval Standard and Partial Correlation Coefficients....Pages 236-246
The Language of Cortical Dynamics....Pages 247-256
A Simple Method to Simultaneously Track the Numbers of Expressed Channel Proteins in a Neuron....Pages 257-267
Back Matter....Pages -
