This book constitutes the refereed proceedings of the First International Symposium on Computational Life Sciences, CompLife 2005, held in Konstanz, Germany in September 2005.
The 21 revised full papers presented together with 3 papers of a workshop on Distributed Data Mining in the Life Sciences (LifeDDM) were carefully reviewed and selected from 49 initial submissions. The papers cover areas ranging from high-level system biology to data analysis related to mass spec traces and are organized in topical sections on systems biology, data analysis and integration, structural biology, genomics, computational proteomics, molecular informatics, molecular structure determination and simulation, and distributed data mining.
Author(s): Gihan Dawelbait, Christian Pilarsky, Yanju Zhang, Robert Grützmann, Michael Schroeder (auth.), Michael R. Berthold, Robert C. Glen, Kay Diederichs, Oliver Kohlbacher, Ingrid Fischer (eds.)
Series: Lecture Notes in Computer Science 3695
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2005
Language: English
Pages: 280
Tags: Information Storage and Retrieval; Health Informatics; Database Management; Information Systems Applications (incl.Internet); Proteomics; Bioinformatics
Front Matter....Pages -
Structural Protein Interactions Predict Kinase-Inhibitor Interactions in Upregulated Pancreas Tumour Genes Expression Data....Pages 1-11
Biochemical Pathway Analysis via Signature Mining....Pages 12-23
Recurrent Neuro-fuzzy Network Models for Reverse Engineering Gene Regulatory Interactions....Pages 24-34
Some Applications of Dummy Point Scatterers for Phasing in Macromolecular X-Ray Crystallography....Pages 35-45
BioRegistry: A Structured Metadata Repository for Bioinformatic Databases....Pages 46-56
Robust Perron Cluster Analysis for Various Applications in Computational Life Science....Pages 57-66
Multiple Alignment of Protein Structures in Three Dimensions....Pages 67-78
Protein Annotation by Secondary Structure Based Alignments (PASSTA)....Pages 79-90
MAPPIS: Multiple 3D Alignment of Protein-Protein Interfaces....Pages 91-103
Frequent Itemsets for Genomic Profiling....Pages 104-116
Gene Selection Through Sensitivity Analysis of Support Vector Machines....Pages 117-127
The Breakpoint Graph in Ciliates....Pages 128-139
ProSpect: An R Package for Analyzing SELDI Measurements Identifying Protein Biomarkers....Pages 140-150
Algorithms for the Automated Absolute Quantification of Diagnostic Markers in Complex Proteomics Samples....Pages 151-162
Detection of Protein Assemblies in Crystals....Pages 163-174
Molecular Similarity Searching Using COSMO Screening Charges (COSMO/3PP)....Pages 175-185
Increasing Diversity in In-silico Screening with Target Flexibility....Pages 186-197
Multiple Semi-flexible 3D Superposition of Drug-Sized Molecules....Pages 198-207
Efficiency Considerations in Solving Smoluchowski Equations for Rough Potentials....Pages 208-216
Fast and Accurate Structural RNA Alignment by Progressive Lagrangian Optimization....Pages 217-228
Visual Analysis of Molecular Conformations by Means of a Dynamic Density Mixture Model....Pages 229-240
Distributed BLAST in a Grid Computing Context....Pages 241-252
Parallel Tuning of Support Vector Machine Learning Parameters for Large and Unbalanced Data Sets....Pages 253-264
The Architecture of a Proteomic Network in the Yeast....Pages 265-276
Back Matter....Pages -
