This book constitutes the thoroughly refereed post-conference proceedings of the Fifth International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2008, held in Vietri sul Mare, Italy, in October 2008.
The 23 revised full papers presented together with 3 invited lectures were carefully reviewed and selected from 69 submissions. The main goal of the CIBB meetings is to provide a forum open to researchers from different disciplines to present and discuss problems concerning computational techniques in bioinformatics, systems biology and medical informatics with a particular focus on neural networks, machine learning, fuzzy logic, and evolutionary computation methods.
Author(s): Gennady M. Verkhivker (auth.), Francesco Masulli, Roberto Tagliaferri, Gennady M. Verkhivker (eds.)
Series: Lecture Notes in Computer Science 5488 : Lecture Notes in Bioinformatics
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2009
Language: English
Pages: 294
Tags: Database Management; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Health Informatics; Artificial Intelligence (incl. Robotics); Algorithm Analysis and Problem Complexity
Front Matter....Pages -
Coarse-Grained Modeling of the HIV–1 Protease Binding Mechanisms: I. Targeting Structural Flexibility of the Protease Flaps and Implications for Drug Design....Pages 1-12
Coarse-Grained Modeling of the HIV–1 Protease Binding Mechanisms: II. Folding Inhibition....Pages 13-24
Unsupervised Stability-Based Ensembles to Discover Reliable Structures in Complex Bio-molecular Data....Pages 25-43
Comparative In Silico Evaluation of MYB Transcription Factors in Eucalyptus, Sugarcane and Rice Transcriptomes....Pages 44-55
Building Maps of Drugs Mode-of-Action from Gene Expression Data....Pages 56-65
In Silico Evaluation of Osmoprotectants in Eucalyptus Transcriptome....Pages 66-77
Mining Association Rule Bases from Integrated Genomic Data and Annotations....Pages 78-90
Stability and Performances in Biclustering Algorithms....Pages 91-101
Splice Site Prediction Using Artificial Neural Networks....Pages 102-113
Interval Length Analysis in Multi Layer Model....Pages 114-122
A Multivariate Algorithm for Gene Selection Based on the Nearest Neighbor Probability....Pages 123-131
Control of Cellular Glycolysis by Perturbations in the Glucose Influx....Pages 132-143
Curating a Large-Scale Regulatory Network by Evaluating Its Consistency with Expression Datasets....Pages 144-155
Spatial Clustering of Molecular Dynamics Trajectories in Protein Unfolding Simulations....Pages 156-166
Clustering Bacteria Species Using Neural Gas: Preliminary Study....Pages 167-176
A New Linear Initialization in SOM for Biomolecular Data....Pages 177-187
3D Volume Reconstruction and Biometric Analysis of Fetal Brain from MR Images....Pages 188-197
Searching for Glycomics Role in Stem Cell Development....Pages 198-209
A New Protein Representation Based on Fragment Contacts: Towards an Improvement of Contact Maps Predictions....Pages 210-221
Analysis of Kernel Based Protein Classification Strategies Using Pairwise Sequence Alignment Measures....Pages 222-231
Topology Preserving Neural Networks for Peptide Design in Drug Discovery....Pages 232-241
A Machine Learning Approach to Mass Spectra Classification with Unsupervised Feature Selection....Pages 242-252
Liver i-Biopsy TM and the Corresponding Intelligent Fibrosis Scoring Systems: i-Metavir F and i-Ishak F....Pages 253-264
An Extension of the TIGR M4 Suite to Preprocess and Visualize Affymetrix Binary Files....Pages 265-274
A Supervised Learning Technique and Its Applications to Computational Biology....Pages 275-283
A Visualization ToolKit Based Application for Representing Macromolecular Surfaces....Pages 284-292
Back Matter....Pages -
