• Covers, for the first time, state-of-the-art research in numerical modeling of some skin properties and functions
• Gathers numerical models from the molecular scale to the tissular scale, as well as some multiscale models and even prospective works based on the systems biology approach
• Presents numerical models related to availability of data as far as possible
• Contains an extensive bibliography associated with each chapter
Summary
The accessibility of the skin in vivo has resulted in the development of non-invasive methods in the past 40 years that offer accurate measurements of skin properties and structures from microscopic to macroscopic levels. However, the mechanisms involved in these properties are still only partly understood. Similar to many other domains, including biomedical engineering, numerical modeling has appeared as a complementary key actor for improving our knowledge of skin physiology.
This book presents, for the first time, the contributions that focus on scientific computing and numerical modeling to offer a deeper understanding of the mechanisms involved in skin physiology. The book is structured around some skin properties and functions, including optical and biomechanical properties and skin barrier function and homeostasis, with—for each of them—several chapters that describe either biological or physical models at different scales.
Author(s): Bernard Querleux
Publisher: Pan Stanford Publishing, CRC Press
Year: 2014
Language: English
Pages: xxi, 534 pages: illustrations
City: [Singapre]
Tags: Биологические дисциплины;Матметоды и моделирование в биологии;
Table of Contents
Preface; Howard I. Maibach
Foreword; Bernard Querleux
PART 1: Skin color
Multilayer Modeling of Skin Color and Translucency; Gladimir V. G. Baranoski, Tenn F. Chen, and Aravind Krishnaswamy
Dermal component based optical modeling of the skin translucency: impact on the skin color; Igor Meglinski, Alexander Doronin, Alexey N. Bashkatov, Elina A. Genina, and Valery V. Tuchin
Mathematics and biological process of skin pigmentation; Josef Thingnes, Leiv Øyehaug, and Eivind Hovig
PART 2: Skin biomechanics
State-of-the-art constitutive models of skin biomechanics; Georges Limbert
Fiber-matrix models of the dermis; Cormac Flynn
Cellular scale model of the stratum corneum; Roberto Santoprete, and Bernard Querleux
PART 3: Skin barrier
Mathematical models of skin permeability: microscopic transport models and their predictions; Gerald B. Kasting, and Johannes M. Nitsche
Cellular scale modelling of the skin barrier; Dirk Feuchter, Michael Heisig, Arne Naegel, Martin Scherer, and Gabriel Wittum
Molecular scale modeling of skin permeation; Sophie Martel, and Pierre-Alain Carrupt
Accessing the molecular organization of the stratum corneum using high resolution electron microscopy and computer simulation; Lars Norlén, Jamshed Anwar, and Ozan Öktem
PART 4: Skin fluids and components
Water diffusion through stratum corneum; Robert E. Imhof, and Peng Xiao
Accurate multi-scale skin model suitable for determining the sensitivity and specificity of changes of skin components; Jürg Fröhlich, Sonja Hulova, Christian Beyer, and Daniel Erni
Model based Quantification of Skin Microcirculatory Perfusion; Ingemar Fredriksson, Marcus Larsson, and Tomas Strömberg
PART 5: Skin homeostasis
Graphical Multi-Scale Modeling of Epidermal Homeostasis with EPISIM; Thomas Sütterlin, and Niels Grabe
Heuristic Modeling Applied to Epidermal Homeostasis; François Iris, Manuel Gea, Paul-Henri Lampe, and Bernard Querleux
