Colorectal Cancer is a complex disease caused by the interaction of hereditary and environmental factors that can be classified based on their importance. Colorectal Cancer Diagnosis and Therapeutic Updates provides comprehensive information about the diagnosis and treatment of colorectal cancer. Chapters first cover the fundamentals of colorectal cancer diagnosis, progressing further towards explaining therapeutic modalities and recent advances in the understanding of the disease.
Key Features
- 11 organized, reader-friendly chapters that provide a complete overview of colorectal cancer
- Covers the colorectal cancer diagnosis, screening and histopathology
- Covers multimodal treatment of colorectal cancer, including chemotherapy, radiotherapy and robotic surgery
- Covers the management and surveillance of colorectal cancer
- Explains the key biochemical mechanisms involved in colorectal cancer treatment
- Covers recent information about colorectal cancer theranostics and drug delivery
- Includes references for further reading in every chapter
The book serves as an introductory reference for medical students and residents on the subject of colorectal cancer. It also serves as a quick reference on the disease for the practicing general physician.
Author(s): Sankha Bhattacharya, Amit Page, Saurabh Maru, Shilpa Dawre
Publisher: Bentham Science Publishers
Year: 2022
Language: English
Pages: 135
City: Singapore
Cover
Title
Copyright
End User License Agreement
Contents
Foreword
Preface
Acknowledgement
List of Contributors
Colorectal Cancer Diagnosis
Sankha Bhattacharya1,*, Amit Page1,*, Kapil Gore1,* and Amaiyya Agrawal1,*
INTRODUCTION
Invasive Examination
NON-INVASIVE DIAGNOSIS METHODS
Fecal Occult Blood Test
Non-enzymatic Tumor Markers
Lysosomal Exoglycosidases as Potential CRC Markers
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Screening for Colorectal Carcinoma
Sankha Bhattacharya1,*, Saurabh Maru1,* and Aseem Setia2,*
INTRODUCTION
DETECTION OF EARLY COLORECTAL CARCINOMA
EARLY DIAGNOSIS OF COLORECTAL CARCINOMA
WHAT IS SCREENING?
WHO SHOULD BE SCREENED?
SCREENING PEOPLE AT AN AVERAGE RISK FOR COLORECTAL CARCINOMA
Fecal Occult Blood Test
Flexible Sigmoidoscopy
Combination of FOBT and Flexible Sigmoidoscopy
Colonoscopy
SCREENING PEOPLE AT INCREASED RISK FOR COLORECTAL CARCINOMA
Genetic Syndromes
NEW SCREENING TESTS
CT Colonography
Faecal Occult Blood Test
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Histopathology
Sankha Bhattacharya1,*, Shilpa Dawre1,* and Dyanesh Saindane1,*
INTRODUCTION
NORMAL HISTOLOGY OF COLORECTAL AREA
GENERAL PRESENTATION IN COLORECTAL CANCER
NEED FOR HISTOPATHOLOGICAL INSPECTION IN COLORECTAL CARCINOMA
FACTORS INVOLVED IN THE HISTOPATHOLOGICAL ANALYSIS OF COLORECTAL CARCINOMA
HISTOPATHOLOGIC DIAGNOSIS OF COLORECTAL CANCER
HISTOLOGIC VARIANTS
GRADING OF COLORECTAL CARCINOMA USING HISTOPATHOLOGICAL ANALYSIS
Process of Grading the Cancers
Issues with PDC System and their Rectification
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Chemotherapy and Colorectal Cancer
Kapil Gore1,*, Dnyanesh Saindane1,* and Sankha Bhattacharya1,*
INTRODUCTION
CHEMOTHERAPY AND COLORECTAL CANCER
Administration of Chemotherapeutic Agents
CHEMOTHERAPY IN DIFFERENT STAGES OF COLORECTAL CANCER
COMPONENTS OF CHEMOTHERAPY
5-Fluorouracil (5-FU)
Irinotecan
Oxaliplatin
NOVEL THERAPIES FOR COLORECTAL CARCINOMA
Agarose Microbeads
Anti-inflammatory Agents
Probiotics
Functional Foods
TARGETED THERAPIES
Targeting EGFR
Cetuximab and Panitumumab
BRAF Inhibitors
HER-2 Inhibitors
Targeting VEGF
Bevacizumab
Novel anti-VEGFR Agents
HGF/C-MET Pathway
HGF Inhibitors
MET Antagonists
TKIs
IMMUNE CHECKPOINT BLOCKADE
ADJUVANT AND NEOADJUVANT THERAPY USING TARGETED MEDICINE
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Robotics for Rectal Cancer
Dnyanesh Saindane1, Ajay Madrewar1 and Sankha Bhattacharya1,*
INTRODUCTION
TOTAL MESORECTAL EXCISION
Techniques Abdominoperineal Resection
Coloanal Anastomosis
LOCAL EXCISION
Transanal Excision
Transcoccygeal Excision
Transsphincteric Excision
Transanal Endoscopic Microsurgery
DISADVANTAGES OF SURGICAL TREATMENT FOR RECTAL CANCER
Short Term Effects of Surgery
Long Term Effects
LAPAROSCOPIC SURGERY
ADVANTAGES OVER CONVENTIONAL SURGICAL METHODS
Short Term Advantages Are:
Long Term Advantages
Limitations of Laparoscopic Surgery
ROBOTIC SURGERY FOR COLORECTAL CANCER
Components of the da Vinci surgical System
Operation of the System
OUTCOMES OF DA VINCI SURGICAL SYSTEM
Short Term Outcomes
Long Term Outcomes
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
lncRNA NLIPMT Inhibitors in Colorectal Cancer Management
Aseem Setia1, Sankha Bhattacharya2,* and Amaiyya Agrawal2
INTRODUCTION
LNCRNA IN COLORECTAL CANCER
HOTAIR
H19
MALAT 1
INVOLVEMENT OF LNCRNAS IN CRC PATHOGENESIS
Wnt/β-Catenin Pathway
EGFR/IGF-IR SIGNALING (PI3K AND KRAS PATHWAYS)
TGF-Β SIGNALING PATHWAY
P53. PATHWAY
EMT PROGRAM
DETAIL DISCUSSION OF EXPERIMENTAL DATA CONDUCTED FOR COLORECTAL CANCER (CRC)
lncRNA Overexpression TGF-β1 Downregulation by NLIPMT Inhibits Colorectal Cancer Cell Migration and Invasion
The Activation of KPNA3 by LncRNA DLEU1 Leads to the Advancement of Colorectal Cancer
CONCLUSION
ABBREVIATIONS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Pathways in Colorectal Cancer
Ajay Madrewar1,*, Kapil Gore1 and Sankha Bhattacharya1
INTRODUCTION
CHROMOSOMAL INSTABILITY PATHWAY
Adenomatous Polyposis Coli gene and wnt Signaling Pathway
TP-53 Mutation
18q Loss of Heterozygosity (LOH)
MICROSATELLITE INSTABILITY PATHWAY
EPIGENETIC INSTABILITY AND CPG METHYLATION
PI3K/AKT PATHWAY, PTEN, AND TGFΒR2
SIGNALLING PATHWAYS IN COLORECTAL CANCER
EGFR/MAPK Signaling Pathway
Notch Signaling Pathway
PI3K Signaling Pathway
TGF-βsignalling Pathway
Wnt Pathway
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Radiotherapy in Colorectal Cancer
Amit Page1, Dnyanesh Saindane2 and Sankha Bhattacharya2,*
INTRODUCTION
TYPES OF RADIATION THERAPY
CLINICAL TRIALS OR RESEARCH STUDIES OF RADIATION AND CHEMO-RADIATION THERAPY IN COLORECTAL CANCER
Neoadjuvant Radiation Therapy
Probable Side Effects of Radiotherapy
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Surveillance for Colorectal Cancer
Saurabh Maru1, Kapil Gore1 and Sankha Bhattacharya1,*
INTRODUCTION
COLONOSCOPY
FLEXIBLE SIGMOIDOSCOPY
CONCLUSIONS
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Recent Theranostics in Treatment of Colorectal Cancer
Shilpa Dawre1, Ajay Madrewar1 and Sankha Bhattacharya1,*
INTRODUCTION
NANOFLATFORMS FOR DRUG DELIVERY AND THERANOSTICS
NANOLIPOSOMAL BASED THERANOSTIC NANOPARTICLES
Prodrug Approach
SUPER MAGNETIC IRON-OXIDE NANOPARTICLES (SPIONS)
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Management of Colorectal Cancer
Sankha Bhattacharya1, Amit Page1, Saurabh Maru1 and Shilpa Dawre1
MANAGEMENT OF COLORECTAL CANCER
HOW CAN YOU PREPARE PATIENTS FOR SURGERY?
Enhanced Recovery After Surgery (ERAS)
Stomal Therapy
Bowel Preparation
Nutritional Interventions
LOCAL RECTAL TREATMENT OF RECTAL CANCER (CLINICS IN THE COLON A RECTAL)
Tumor Evaluation
Electrocoagulation
Contract Radiotherapy
Local Excision
ENDOSCOPIC TREATMENT
Snare Polypectomy
Endoscopic Mucosal Resection (EMR)
Endoscopic Submucosal Dissection
WHAT IS THE SURGICAL OPTION FOR COLORECTAL CANCER?
Open Surgery
Laparoscopic Surgery
WHAT ARE POSSIBLE COMPLICATIONS?
Immediate
Long Term
WHAT IS THE ROLE OF ADJUVANT CHEMOTHERAPY IN COLORECTAL CANCER TREATMENT?
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Subject Index
Back Cover
