Cold atmospheric plasma (CAP) emerges as a possible new modality for cancer treatment. This book provides a comprehensive introduction into fundamentals of the CAP and plasma devices used in plasma medicine. An analysis of the mechanisms of plasma interaction with cancer and normal cells including description of possible mechanisms of plasma selectivity is included. Recent advances in the field, the primary challenges and future directions are presented.
Author(s): Michael Keidar, Dayun Yan, Jonathan H Sherman
Series: IOP Concise Physics
Publisher: IOP Publishing
Year: 2019
Language: English
Pages: 98
City: Bristol
PRELIMS.pdf
Acknowledgements
Author biographies
Michael Keidar
Dayun Yan
Jonathan H Sherman
CH001.pdf
Chapter 1 Plasma as a fourth state of matter
1.1 Plasma types
References
CH002.pdf
Chapter 2 Introduction to the non-thermal plasmas
References
CH003.pdf
Chapter 3 The anti-cancer effect of cold atmospheric plasma in vitro
3.1 The research status
3.2 The specific vulnerability of cancer cells to cap
3.3 The long-term cellular responses
3.4 The selective anti-cancer effect
3.5 The short-term cellular respones
References
CH004.pdf
Chapter 4 The anti-cancer mechanism of cold atmospheric plasma in vitro
4.1 The activation of cancer cells
4.2 The reactive species
4.3 The rise of intracellular ROS
4.4 The selective anti-cancer mechanism
References
CH005.pdf
Chapter 5 The anti-cancer effect of CAP treatment in vivo
5.1 Introduction
5.2 The in vivo demonstration
5.3 The clinical demonstration
5.4 Mechanism
5.5 Reactive species and skin
References
CH006.pdf
Chapter 6 Indirect CAP treamtent, the application of the cold atmospheric plasma-activated solutions in cancer treatment
6.1 Introduction
6.2 The CAP-activated medium
6.3 The reactive species in PAS
6.4 The principles to make PAS
References
CH007.pdf
Chapter 7 Adaptive plasmas and recent progress in plasma application in cancer therapy
7.1 Plasma self-organization phenomena
7.2 Adaptive plasma devices
7.3 MPC-based adaptive plasma platform
References
CH008.pdf
Chapter 8 Clinical applications of cold atmospheric plasma for glioblastoma
8.1 Introduction
8.2 Cold atmospheric plasma as a potential mediator of immune stimulation
Glioblastoma-mediated suppression of the systemic and local immune system
Current immunotherapy approaches in the treatment of GBM
Cold-activated plasma’s role in immunotherapy
8.3 Cold atmospheric plasma-mediated inflammation as a promoter of mesenchymal stem cell localization
Mesenchymal stem cells and the tumor microenvironment
Cold atmospheric plasma inflammation as a mediator of mesenchymal stem cell recruitment
Cold atmospheric plasma and miR-MSC adjuvant therapy in the treatment of glioblastoma
8.4 Cold atmospheric plasma and nanoparticles applied as a synergistic cancer therapy
Nanoparticles and the tumor microenvironment
Cold atmospheric plasma with platinum nanoparticle adjunct therapy
Cold atmospheric plasma with gold nanoparticle adjunct therapy
The future of cold atmospheric plasma and nanoparticle adjunct therapy
8.5 Facing forward: cold atmospheric plasma treatment of glioblastoma
Acknowledgements
References
