This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented. Key Features* The enzymatic mechanisms of protein lipidation* Three-dimensional structures of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase
Author(s): Rose E. Dalbey and David S. Sigman (Eds.)
Series: The Enzymes 22
Edition: 3
Publisher: Elsevier, Academic Press
Year: 2002
Language: English
Pages: 3-501
Content:
Preface
Pages xi-xii
Ross E. Dalbey
1 The eubacterial lipoprotein-specific (type II) signal peptidase Review Article
Pages 3-26
Harold Tjalsma, Geeske Zanen, Sierd Bron, Jan Maarten Van Dijl
2 Bacterial type I signal peptidases Review Article
Pages 27-55
Joseph L. Carlos, Mark Paetzel, Philip A. Klenotic, Natalie C.J. Strynadka, Ross E. Dalbey
3 Structure and function of the endoplasmic reticulum signal peptidase complex Review Article
Pages 57-75
Neil Green, Hong Fang, Stephen Miles, MarkO. Lively
4 Mitochondrial processing peptidase/mitochondrial intermediate peptidase Review Article
Pages 77-100
Jiri Adamec, Frantisek Kalousek, Grazia Isaya
5 Chloroplast and mitochondrial type I signal peptidases Review Article
Pages 101-125
Christopher J. Howe, Kevin A. Floyd
6 Type IV prepilin leader peptidases Review Article
Pages 127-159
Mark S. Strom, Stephen Lory
7 The prohormone convertases and precursor processing in protein biosynthesis Review Article
Pages 163-198
Donald F. Steiner
8 Furin Review Article
Pages 199-235
Sean S. Molloy, Gary Thomas
9 Cellular limited proteolysis of precursor proteins and peptides Review Article
Pages 237-258
Nabil G. Seidah
10 Yeast Kex2 protease Review Article
Pages 259-289
Nathan C. Rockwell, Robert S. Fuller
11 The enzymology of PC1 and PC2 Review Article
Pages 291-332
A. Cameron, E.V. Apletalina, I. Lindberg
12 Self-processing of subunits of the proteasome Review Article
Pages 335-371
Erika Seemüller, Peter Zwickl, Wolfgang Baumeister
13 Tsp and related tail-specific proteases Review Article
Pages 373-386
Kenneth C. Keiler, Robert T. Sauer
14 Co- and posttranslational processing: The removal of methionine Review Article
Pages 387-420
Ralph A. Bradshaw, Christopher J. Hope, Elizabeth Yi, Kenneth W. Walker
15 Carboxypeptidases E and D Review Article
Pages 421-452
Lloyd D. Fricker
Author index
Pages 453-491
Subject index
Pages 493-501,I-VII
