Clinical Tuberculosis remains an indispensable resource for respiratory physicians, infectious disease specialists, public health workers and other individuals involved in the management and control of tuberculosis worldwide. This established reference is a comprehensive accoutn of tuberculosis, providing up-to-date and authoritative information on all aspects of the disease. It gives practical guidance to health professionals who may be involved in any aspect of patient management or disease control, including chapters on epidemiology, pathology, immunology, disease presentation, diagnosis, treatment and management options. Specific consideration is given to the problems of TB associated with HIV infection, and issues of control relating to low and high prevalence countries respectively. The ongoing issues surrounding the BCG vaccination and preventive therapy are also covered, as are the increasing problems of multi-drug resistant strains and environmental opportunist mycobacteria.
Author(s): Peter D Davies, Peeter Barnes, Stephen B Gordon
Edition: 4
Year: 2008
Language: English
Pages: 670
Book title......Page 4
Contents......Page 8
List of contributors......Page 10
Foreword......Page 14
Preface......Page 16
Acknowledgements......Page 18
PART 1 BACKGROUND......Page 20
1 The history of tuberculosis from earliest times to the development of drugs......Page 22
2 Epidemiology......Page 40
PART 2 PATHOLOGY AND IMMUNOLOGY......Page 62
3 Genotyping and its implications for transmission dynamics and tuberculosis......Page 64
4 Mycobacterium tuberculosis: the organism......Page 84
5 The diagnosis of tuberculosis......Page 98
6 Immunodiagnostic tests......Page 110
7 Histopathology......Page 124
8 Human immune response to tuberculosis......Page 140
PART 3 CLINICAL ASPECTS......Page 162
9 Respiratory tuberculosis......Page 164
10 Non-respiratory tuberculosis......Page 182
11 Tuberculosis in childhood......Page 208
PART 4 TREATMENT......Page 222
12 Clinical pharmacology of the antituberculosis drugs......Page 224
13 Chemotherapy including drug-resistant therapy and future developments......Page 244
14 New developments in treatment......Page 262
15 International standards for tuberculosis care: integrating tuberculosis care and control......Page 272
16 The surgical management of tuberculosis and its complications......Page 288
17 Directly observed therapy and other aspects of management of tuberculosis care......Page 306
18 DOTS and DOTS-Plus......Page 318
PART 5 TUBERCULOSIS IN SPECIAL SITUATIONS......Page 332
19 The association between HIV and tuberculosis in the developing world, with special focus on sub-Saharan Africa......Page 334
20 HIV and TB in industrialized countries......Page 362
21 Tuberculosis and migration......Page 386
PART 6 PREVENTION......Page 402
22 Preventive therapy......Page 404
23 Clinical interpretation of tests for latent tuberculosis infection......Page 412
24 BCG vaccination......Page 430
PART 7 CONTROL......Page 448
25 Control of tuberculosis in low-prevalence countries......Page 450
26 Control of tuberculosis in high-prevalence countries......Page 476
27 The role of the specialist TB nurse......Page 500
28 Global Plan to Stop TB 2006–2015......Page 508
PART 8 RELATED ASPECTS......Page 526
29 Environmental mycobacteria......Page 528
30 Animal tuberculosis......Page 538
PART 9 CONCLUSIONS......Page 548
31 Conclusions......Page 550
A......Page 558
C......Page 559
D......Page 561
E......Page 562
G......Page 563
H......Page 564
I......Page 566
L......Page 567
M......Page 568
N......Page 569
P......Page 570
R......Page 571
S......Page 572
T......Page 573
Z......Page 574
