When a patient is diagnosed with a gynecological malignancy, she and her doctors must make urgent, high-risk decisions about her course of treatment. In selecting an appropriate plan of care, physicians must weigh the patient’s individual needs, the tumor’s specific characteristics, and the treatment’s potential side effects. Because there is no one-size-fits-all treatment solution, a plethora of clinical trials have been performed on ovarian cancer patients, but clinicians may struggle to keep up with this ever-growing body of research.
Collecting and synthesizing research findings from a wide array of medical journal articles and book chapters, Clinical Trials in Ovarian Cancer provides physicians with an invaluable resource. Gynecologic oncologist Christine S. Walsh systematically outlines each of the seminal Phase III trials that have shaped the treatment of ovarian cancers, detailing the rationale for the trial, the patient population studied, treatment delivery methods, efficacy, toxicity, and trial conclusions. She provides a clear overview of established treatments, as well as still-controversial experimental approaches.
The first book to organize this cutting-edge research into an easy-to-use reference, Clinical Trials in Ovarian Cancer should help medical personnel at all levels provide their patients with the highest standard of care.
CHRISTINE S. WALSH is an associate professor and attending physician at Cedars-Sinai hospital in Los Angeles, California. She is also associate professor at the Geffen School of Medicine at UCLA. She serves as director for the gynecologic oncology fellowship program.
Author(s): Christine S. Walsh
Publisher: Rutgers University Press
Year: 2017
Language: English
Pages: 336
Title Page
......Page 4
Copyright
......Page 5
Dedication
......Page 6
Contents
......Page 8
List of Tables......Page 10
Preface and Acknowledgments
......Page 12
GOG 7601 (Young, NEJM 1990)
......Page 14
GOG 7602 (Young, NEJM 1990)
......Page 18
GICOG Trials (Bolis, Ann Oncol 1995)
......Page 22
GOG 95 (Young, JCO 2003)
......Page 28
ICON1/ACTION Combined Analysis (Trimbos, JNCI 2003)
......Page 32
ACTION (Trimbos, JNCI 2003; Trimbos, JNCI 2010)
......Page 37
ICON1 (Colombo, JNCI 2003)
......Page 45
GOG 157 (Bell, Gynecol Oncol 2006)
......Page 50
GOG 157 Exploratory Analysis (Chan, Gynecol Oncol 2010)
......Page 56
GOG 47 (Omura, Cancer 1986)
......Page 59
GOG 52 (Omura, JCO 1989)
......Page 63
GOG 97 (McGuire, JCO 1995)
......Page 66
GOG 111 (McGuire, NEJM 1996)
......Page 70
GOG 104 (Alberts, NEJM 1996)
......Page 75
ICON2 (Lancet 1998)
......Page 79
GOG 132 (Muggia, JCO 2000)
......Page 83
Danish Netherlands Trial (Neijt, JCO 2000)
......Page 88
OV-10 (Piccart, JNCI 2000)
......Page 93
GOG 114 (Markman, JCO 2001)
......Page 99
ICON3 (Lancet 2002)
......Page 103
GOG 158 (Ozols, JCO 2003)
......Page 108
AGO/OVAR-3 (du Bois, JNCI 2003)
......Page 113
SCOTROC—Scottish Randomised Trial in Ovarian Cancer (Vasey, JNCI 2004)
......Page 118
GOG 172 (Armstrong, NEJM 2006)
......Page 122
GOG 182/ICON5 (Bookman, JCO 2009)
......Page 127
JGOG 3016 (Katsumata, Lancet 2009; Katsumata, Lancet Oncol 2013)
......Page 132
MITO-2 (Pignata, Oncology 2009; Pignata, JCO 2011)
......Page 139
AGO-OVAR9 (du Bois, JCO 2010)
......Page 145
OV16 (Hoskins, JNCI 2010)
......Page 150
ICON7 (Perren, NEJM 2011; Oza, Lancet Oncol 2015)
......Page 158
GOG 218 (Burger, NEJM 2011)
......Page 164
MITO-7 (Pignata, Lancel Oncol 2014)
......Page 170
EORTC-GCG 55865 (van der Burg, NEJM 1995)
......Page 175
GOG 152 (Rose, NEJM 2004)
......Page 181
EORTC 55971 (Vergote, NEJM 2010)
......Page 187
CHORUS (Kehoe, Lancet 2015)
......Page 191
GOG 178/SWOG 9701 (Markman, JCO 2003)
......Page 199
GOG 175 (Mannel, Gynecol Oncol 2011)
......Page 206
Topotecan Versus Paclitaxel (ten Bokkel, JCO 1997)
......Page 213
Doxil Study 30-49 (Gordon, JCO 2001; Gordon, Gyn Onc 2004)
......Page 220
ICON4/AGO- OVAR 2.2 (Parmar, Lancet 2003)
......Page 230
AGO-OVAR, NCIC CTG, EORTC GCG Trial (Pfisterer, JCO 2006)
......Page 235
Gemcitabine Versus PLD (Mutch, JCO 2007)
......Page 241
OVA-301 (Monk, JCO 2010)
......Page 248
CALYPSO (Pujade-Lauraine, JCO 2010)
......Page 255
OCEANS (Aghajanian, JCO 2012)
......Page 262
AURELIA (Pujade-Lauraine, JCO 2014)
......Page 269
Abbreviations......Page 276
References......Page 280
Index......Page 308
About the Author......Page 336
