This authoritative book discusses the use of clinical trials in health sciences including why they are important, how to do them and how they can be used most relevantly in health care for the future.The chapters are based on papers given at an Oxford seminar by leading figures in this field and the discussions that followed. The book will be of particular interest to clinical trialists and the pharmaceutical industry.
Author(s): Lelia Duley, Barbara Farrell
Edition: 1
Year: 2001
Language: English
Pages: 144
Contents......Page 4
Contributors......Page 6
Foreword......Page 9
Preface......Page 10
Acknowledgements......Page 11
1 Comparing like with like and the development of randomisation – goodbye anecdotes......Page 12
2 Why we need randomised controlled trials......Page 24
3 The importance of The Cochrane Controlled Trials Register to people doing and interpreting randomised trials......Page 36
4 What have we learned from 50 years of randomised trials for people with schizophrenia?......Page 44
5 Big is still beautiful: why we still need large simple trials......Page 53
6 Improving the quality, number and progress of randomised controlled trials......Page 68
7 The nuts and bolts of doing a clinical trial......Page 83
8 Building resources for randomised trials......Page 92
9 The role of data monitoring committees......Page 108
10 Bayesian perspectives on the ethics of trials......Page 116
11 “Empowering” patient choice about participation in trials?......Page 132
C......Page 140
E......Page 141
M......Page 142
R......Page 143
W......Page 144
