Author(s): Fra A. Barile
Edition: 1
Year: 2003
Language: English
Pages: 480
Book Cover......Page 1
Title......Page 4
Copyright......Page 5
Dedication......Page 6
Preface......Page 8
The Author......Page 10
Contributors......Page 12
Contents......Page 14
Part I Introduction to Basic Toxicological Principles......Page 34
1 Introduction......Page 36
2 Risk Assessment and Regulatory Toxicology......Page 42
3 Therapeutic Monitoring of Adverse Drug Reactions (ADRs)......Page 52
4 Classi.cation of Toxins in Humans......Page 68
5 Exposure......Page 88
6 Effects......Page 94
7 Dose-Response......Page 102
8 Descriptive Animal Toxicity Tests......Page 110
9 In Vitro Alternatives to Animal Toxicity......Page 116
10 Toxicokinetics......Page 120
Part II Toxicity of Therapeutic Agents......Page 140
11 Sedative/Hypnotics......Page 142
12 Opioids and Derivatives......Page 154
13 Sympathomimetics......Page 168
14 Hallucinogenic Agents......Page 186
15 Anticholinergic and Neuroleptic Drugs......Page 204
16 Acetaminophen, Salicylates, and Nonsteroidal Anti- In.ammatory Drugs (NSAIDs)......Page 216
17 Steroids......Page 230
18 Cardiovascular Drugs......Page 240
19 Antineoplastic Agents......Page 256
20 Vitamins......Page 266
21 Herbal Remedies......Page 278
Part III Toxicity of Nontherapeutic Agents......Page 294
22 Alcohols and Aldehydes......Page 296
23 Gases......Page 310
24 Metals......Page 328
25 Aliphatic and Aromatic Hydrocarbons......Page 352
26 Insecticides......Page 364
27 Herbicides......Page 376
28 Rodenticides......Page 384
29 Chemical Carcinogenesis and Mutagenesis......Page 392
30 Reproductive and Developmental Toxicity......Page 410
31 Radiation Toxicity......Page 420
32 Chemical and Biological Threats to Public Safety......Page 430
Index......Page 448
