The book, Clinical Studies in Nutraceuticals and Dietary Supplements, presents extensive information on all the vital aspects and evidence-based studies on nutraceuticals and dietary supplements. The most fascinating part of this book is that the chapters explore the key concept accompanying an emphasis on recent research and developments on nutraceuticals and dietary supplements to tackle various diseases including maternal and fetal health, cancer, cardiovascular, renal disorders, hepatic disorders, hormonal disorders, and neurological dysfunction. The introspection carries updated literature reviews with relevant vital topics, quality illustrations, and well-organized tables for a better understanding of each segment. The current market scenario of these nutraceuticals and dietary supplements is the emphasis on their importance for a healthy and disease-controlled environment. This book will be useful to research scholars and scientists, as well as individuals working in the nutraceutical, dietary supplement, and functional food industries. This is an initiative to unveil the immense wealth that these nutraceuticals and dietary supplements hold and a realization of the fact that more evidence-based studies are required for its use to curb maladies and foster a healthy lifestyle.
Author(s): Sreeraj Gopi, Augustine Amalraj, Akhila Nair, Divya Chandradhara
Publisher: CRC Press
Year: 2022
Language: English
Pages: 210
City: Boca Raton
Cover
Half Title
Title Page
Copyright Page
Contents
Preface
Editor Biographies
Contributors
1. General Classification and Basic Clinical Information Pertaining to Nutraceuticals and Dietary Supplements against Various Diseases
1.1 Introduction
1.2 Classification of Nutraceuticals and Dietary Supplements
1.3 Nutraceuticals and Dietary Supplements for Various Diseases
1.3.1 Maternal and Fetal Health
1.3.2 Cardiovascular Diseases
1.3.3 Cancer
1.3.4 Gastrointestinal Disorders
1.3.5 Bone Health
1.3.6 Neurological Disorders
1.3.7 Hepatic Disorders
1.3.8 Renal Disorders
1.3.9 Diabetes
1.4 Conclusion
Acknowledgment
Conflict of Interest
References
2. New Regulatory Norms Promulgated for Nutraceuticals and Dietary Supplements to Address the Challenges regarding Its Safety and Efficacy
2.1 Introduction
2.2 Opportunities for Nutraceuticals and Dietary Supplements
2.3 Challenges in Global Regulatory Market
2.3.1 Physicochemical Properties
2.3.2 Regulatory Vagueness and Label Claim
2.4 Global Regulatory Norms for Nutraceuticals and Dietary Supplements
2.4.1 USA
2.4.2 European Union
2.4.3 Asian
2.4.3.1 India
2.4.3.2 China
2.4.3.3 Japan
2.5 Conclusion
Acknowledgment
Conflict of Interest
References
3. An Outlook on Clinical Trials of Nutraceuticals and Dietary Supplements on Maternal and Fetal Health
3.1 Introduction
3.2 Importance of Natural Supplements for Maternal and Fetal Health
3.2.1 Folic Acid
3.2.2 Vitamin D
3.2.3 Sulforaphane
3.2.4 Melatonin
3.2.5 Inositol
3.2.6 Resveratrol
3.2.7 Garlic (Allium Sativum)
3.2.8 Stinging Nettle (Laportea Interrupta L.)
3.3 Clinical Directions of Nutraceuticals and Dietary Supplements
3.4 Conclusion
Acknowledgment
Conflict of Interest
References
4. The Role of Nutraceuticals and Dietary Supplements in the Prevention of Cardiovascular Diseases: An Insight on the Clinical Trials
4.1 Introduction
4.2 Nutraceuticals
4.2.1 Sterols/stanols
4.2.2 Polyphenols
4.2.3 Spirulina
4.3 Dietary Supplements
4.3.1 Vitamin D
4.3.2 Probiotics
4.3.3 CoQ10
4.3.4 Vitamin C
4.4 Conclusion
Conflict of Interest
References
5. Advances in Clinical Pathways in Various Cancer Treatments, Which Lead the Dietary Supplements and Nutraceuticals to See the Light at the End of the Tunnel
5.1 Introduction
5.2 Nutraceuticals and Dietary Supplements for Cancer Treatment
5.2.1 Herbal Products
5.2.2 Prebiotics
5.2.3 Probiotics
5.2.4 Antioxidants
5.2.5 Polyunsaturated Fatty Acids
5.2.5.1 Omega-3 Fatty Acids
5.2.5.2 Omega-6 Fatty Acids
5.2.6 Fibers
5.3 Side Effects
5.4 Conclusion
Acknowledgment
Conflict of Interest
References
6. Recent Advances in the Clinical Trials of Dietary Nutraceuticals to Altercate with Gastrointestinal Diseases
6.1 Introduction
6.2 Inflammatory Bowel Disease
6.2.1 Curcumin
6.2.2 Herbs and Plant Extracts
6.2.3 Prebiotics and Probiotics
6.2.4 Vitamin D
6.2.5 Omega-3 Fatty Acids
6.3 Irritable Bowel Syndrome
6.4 Gastroesophageal Reflux Disease
6.5 Functional Dyspepsia
6.6 Constipation
6.7 Conclusion
Acknowledgment
Conflict of Interest
References
7. Nutraceuticals and Dietary Supplements Endorse Bone Health: A Rationale behind the Thriving Triumph of Clinical Trials
7.1 What Is Nutraceuticals?
7.2 Sources of Nutraceuticals
7.3 Classification of Nutraceuticals
7.3.1 Probiotics
7.3.2 Prebiotics
7.3.3 Dietary Fiber
7.3.4 Polyunsaturated Fatty Acids
7.3.5 Antioxidant Vitamins
7.3.6 Polyphenols
7.3.7 Spices
7.4 Nutraceuticals: How They Work as Therapeutic Agents?
7.5 Strategic Design of Delivery Systems for Nutraceuticals
7.5.1 Biodegradable Polymers
7.5.2 Nanoemulsions
7.5.3 Polymeric Nanoparticles
7.5.4 Micelles
7.5.5 Liposome
7.5.6 Nanoliposomes
7.5.7 Lipid Nanoparticles
7.5.8 Nanocapsules
7.5.9 Nanospheres
7.6 Effects of Nutraceuticals and Dietary Supplements on Bone Health, Beyond Calcium and Vitamin D
7.6.1 Calcium
7.6.2 Vitamin D
7.6.3 Dehydroepiandrosterone
7.6.4 Flavonoids
7.6.5 Omega-3 Fatty Acids
7.6.6 Carotenoids
7.6.7 Vitamin C
7.6.8 Vitamin K
7.6.9 Vitamin B
7.6.10 Magnesium
7.6.11 Boron
7.6.12 Silicon
7.6.13 Strontium
7.6.14 Phosphorus
7.7 Role of Nutraceuticals and Dietary Supplements on Improving Bone Health in Clinical Context
7.8 Scientific and Regulatory Aspects of Nutraceuticals Products
7.9 Future Prospects and Conclusion
Acknowledgment
Conflict of Interest
References
8. Scientific Basis and Developments in the Clinical Aspects of Nutraceutical and Dietary Supplements for Neurological and Cognitive Dysfunction
8.1 Introduction
8.2 Nutraceuticals and Their Categories
8.2.1 Traditional Nutraceuticals (Food-Based Nutraceuticals)
8.2.1.1 Nutrients
8.2.1.2 Herbals and Extracts or Concentrates of Plant Products
8.2.1.3 Probiotic Micro-Organisms
8.2.1.4 Nutraceutical Enzymes
8.2.2 Nontraditional Nutraceuticals
8.2.2.1 Fortified Nutraceuticals
8.2.2.2 Recombinant Nutraceuticals
8.2.3 Based on the Mechanism of Action
8.2.4 Based on the Chemical Nature of the Products
8.3 Nutraceuticals in Neurodegenerative Disorders
8.3.1 Quercetin and Kaempferol
8.3.2 Withanine
8.3.3 Asiatic Acid
8.3.4 Bhilavanol A and Bhilavanol B
8.4 Nutraceuticals in Parkinson's Disease
8.5 Nutraceuticals in Depression
8.6 Nutraceuticals in Alzheimer's Disease
8.6.1 Flavonoids
8.6.2 Carotenoids
8.6.3 Crocin
8.6.4 Cyanidin
8.6.5 Luteolin
8.7 Nutraceuticals in Psychotic Disorders
8.8 Conclusions
Acknowledgment
Conflict of Interest
References
9. Current Clinical Evidences of Promising Benediction of Nutraceutical and Dietary Supplements for Hepatic Disorders
9.1 Introduction
9.2 Medicinal Plants with Hepatic Protective Actions
9.2.1 Phyllanthus amarus schum. et thonn.
9.2.2 Silybum marianum (L.)gaertn
9.2.3 Glycyrrhiza glabra L.
9.2.4 Picrorhiza kurroa royle ex benth
9.2.5 Ocimum sanctum L.
9.2.6 Curcuma longa L. (Curcumin)
9.2.7 Rhizoma coptidis (Berberine)
9.2.8 Resveratrol
9.3 New Research Avenues for Natural Liver Protectors
9.4 Limitations of Current Traditional Natural Herbal Medicine
9.5 Conclusion
Acknowledgment
Conflict of Interest
References
10. Concomitant Use of Natural Supplements on Hormonal Growth and Disorders from Recent Clinical Perspectives and Trend
10.1 Introduction
10.2 Endocrine Disorders
10.2.1 Sexual Dysfunctions and Reproductive Hormones
10.2.2 Diabetes Mellitus
10.2.3 Polycystic Ovary Syndrome and Dysmenorrhoea
10.2.4 Parathyroid Dysfunction
10.2.5 Pancreatic/Neuroendocrine Tumors
10.3 Conclusion
Acknowledgment
Conflict of Interest
References
11. Recommendation of Dietary and Nutraceutical Supplements for Chronic Renal Diseases Through Current Clinical Evidence
11.1 Introduction: Nutraceuticals and Dietary Supplements: The Unending Debate
11.2 Chronic Kidney Disease: Overview
11.2.1 Causes
11.2.1.1 Diabetes
11.2.1.2 High Blood Pressure
11.2.1.3 Other Causes of Kidney Disease [National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)]
11.2.2 Ways to Manage the Kidney Disease (NIDDK)
11.2.3 Nutrition and CKD
11.2.3.1 Guidelines for CKD
11.3 Nutritional Treatment of CKD: Evidences from Clinical Studies
11.3.1 Polyphenols
11.3.2 Curcumin
11.3.3 Resveratrol
11.3.4 Steviol
11.3.5 Nitrates/Nitrites
11.4 Bridging the Gap and Way Ahead
Acknowledgment
Conflict of Interest
References
12. Nutraceuticals and Dietary Supplements: The Future Smart Foods to Hamper Diabetes Mellitus and Associated Complications
12.1 Introduction
12.2 Categories of Nutraceuticals and Their Role in Diabetes
12.2.1 Isolated Nutrients
12.2.2 Herbals
12.2.3 Probiotics
12.3 Associated Complications of Diabetes
12.4 Conclusion
Acknowledgment
Conflict of Interest
References
13. A Comparison of the Present-Day Growth Pattern in the World Economy of Dietary and Nutraceutical Supplements with Generic Medicines After Clinical Encounter: A Day in the Sun
13.1 Introduction to Dietary and Nutraceutical Supplements
13.2 Dietary and Nutraceuticals Supplement - Clinical Trials
13.2.1 High Blood Pressure
13.2.2 Diabetics
13.2.3 Obesity
13.2.4 Cancer
13.3 Global Market of Dietary and Nutraceutical Supplements
13.4 Conclusion
Acknowledgment
Conflict of Interest
References
Index
