Clinics for cardiogenetic disorders have been established in many academic teaching hospitals in Europe. In these clinics, cardiologists, clinical and molecular geneticists, genetic nurses, and social workers closely cooperate to provide optimal care for individuals with cardiac disease of probable genetic origin and their family members. However, the prevalence of genetic cardiomyopathies and primary electrical heart diseases is sufficiently high, that it is neither desirable nor possible that the care for this group of patients and their relatives remains solely restricted to a small number of academic centers. Therefore basic knowledge on the genetic aspects of these types of disorders and on what to do with as yet asymptomatic at-risk family members should be considered to be a prerequisite for all practising cardiologists. Many cardiologists have not been specifically trained in genetics, let alone in explaining genetics to their patients. Clinical Cardiogenetics compiles the massive amount of information available in a single easy to read textbook. It does not require prior expert genetic knowledge and provides a practical clinical primer for cardiologists and other physicians involved in the management of these patients. With the continuing increase in genetic knowledge, and the expanding possibilities to prevent fatal arrhythmias in those individuals at high risk, a steady increase in questions regarding genetics from patients and their relatives in the years to come should be expected. This comprehensive textbook is a valuable tool in dealing with such questions.
Author(s): M. M. A. M. Mannens, H. J. M. Smeets (auth.), H.F. Baars, P.A.F.M. Doevendans, J.J. van der Smagt (eds.)
Edition: 1
Publisher: Springer-Verlag London
Year: 2011
Language: English
Pages: 455
Tags: Cardiology; Human Genetics; Internal Medicine
Front Matter....Pages i-xv
Front Matter....Pages 1-1
Introduction to Molecular Genetics....Pages 3-19
Clinical Genetics....Pages 21-44
Front Matter....Pages 45-45
Hypertrophic Cardiomyopathy....Pages 47-61
Familial Dilated Cardiomyopathy....Pages 63-77
Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy....Pages 79-96
Noncompaction Cardiomyopathy....Pages 97-122
Mitochondrial Cardiomyopathy....Pages 123-128
Restrictive Cardiomyopathy....Pages 129-139
Front Matter....Pages 141-141
Congenital Long QT-Syndrome....Pages 143-164
The Brugada Syndrome....Pages 165-187
Short QT Syndrome....Pages 189-196
Catecholaminergic Polymorphic Ventricular Tachycardia....Pages 197-206
A Molecular Genetic Perspective on Atrial Fibrillation....Pages 207-225
Front Matter....Pages 227-227
Idiopathic Ventricular Fibrillation....Pages 229-238
The Genetics of Mitral Valve Prolapse....Pages 239-242
Atrioventricular (AV) Reentry Tachycardia....Pages 243-252
Hereditary Cardiac Conduction Diseases....Pages 253-260
Front Matter....Pages 261-261
Connective Tissue Disorders and Smooth Muscle Disorders in Cardiology....Pages 263-282
Genetics of Congenital Heart Defects....Pages 283-304
Genetic Disorders of the Lipoprotein Metabolism; Diagnosis and Management....Pages 305-330
Front Matter....Pages 261-261
Novel Insights into Genetics of Arterial Thrombosis....Pages 331-351
The Pharmacogenetics of Atherosclerosis....Pages 353-367
Genetics of (Premature) Coronary Artery Disease....Pages 369-383
Hereditary Neuromuscular Diseases and Cardiac Involvement....Pages 385-400
Sudden Cardiac Death in the Young; Epidemiology and Cardiogenetic Evaluation of Victims and Their Relatives....Pages 401-412
The Outpatient Clinic for Cardiogenetics....Pages 413-422
Abdominal Aortic Aneurysm....Pages 423-435
Future of Cardiogenetics....Pages 437-442
Back Matter....Pages 443-455
