Chronic liver failure is a frequent condition in clinical practice that encompasses all manifestations of patients with end-stage liver diseases. Chronic liver failure is a multiorgan syndrome that affects the liver, kidneys, brain, heart, lungs, adrenal glands, and vascular, coagulation, and immune systems. Chronic Liver Failure: Mechanisms and Management covers for the first time all aspects of chronic liver failure in a single book, from pathogenesis to current management. Each chapter is written by a worldwide known expert in their area and all provide the latest state-of-the-art knowledge. This volume is specifically designed to provide answers to clinical questions to all doctors dealing with patients with liver diseases, not only clinical gastroenterologists and hepatologists, but also to internists, nephrologists, intensive care physicians, and transplant surgeons.
Author(s): Fabio Marra, Maurizio Parola (auth.), Pere Ginès, Patrick S. Kamath, Vicente Arroyo (eds.)
Series: Clinical Gastroenterology
Edition: 1
Publisher: Humana Press
Year: 2011
Language: English
Pages: 590
Tags: Gastroenterology; Hepatology; Transplant Surgery
Front Matter....Pages i-xviii
Front Matter....Pages 1-1
Cells in the Liver—Functions in Health and Disease....Pages 3-32
Liver Physiology....Pages 33-45
Assessment of Liver Function in Clinical Practice....Pages 47-76
Physiology of the Splanchnic and Hepatic Circulations....Pages 77-90
Fibrosis as a Major Mechanism of Chronic Liver Disease....Pages 91-107
Stem Cells and Chronic Liver Failure: Potential New Therapeutics....Pages 109-129
The Role of Inflammatory Mediators in Liver Failure....Pages 131-153
Genomics of the Liver in Health and Disease....Pages 155-167
Front Matter....Pages 169-169
Hepatic Encephalopathy and Alterations of Cerebral Function....Pages 171-187
Bacterial Translocation and Alterations of the Digestive System....Pages 189-218
SIRS, Bacterial Infections, and Alterations of the Immune System....Pages 219-238
Regulation of the Extracellular Fluid Volume and Renal Function....Pages 239-267
The Heart in Chronic Liver Failure....Pages 269-288
Haemostasis Abnormalities in Chronic Liver Failure....Pages 289-303
The Systemic and Splanchnic Circulations....Pages 305-321
Hepatic Microcirculation....Pages 323-341
Angiogenesis and Vascular Growth in Liver Diseases....Pages 343-359
Pulmonary Alterations in Chronic Liver Failure....Pages 361-376
Adrenal Function in Chronic Liver Failure....Pages 377-391
Front Matter....Pages 393-393
Antibiotic Prophylaxis and Management of Bacterial Infections....Pages 395-410
Front Matter....Pages 393-393
Management of Ascites and Hyponatremia....Pages 411-427
Management of Renal Failure....Pages 429-451
Correction of Abnormalities of Haemostasis in Chronic Liver Disease....Pages 453-476
The Treatment and Prevention of Variceal Bleeding....Pages 477-500
Extracorporeal Artificial Liver Support Systems....Pages 501-519
Issues in Transplantation of Patients with Chronic Liver Failure....Pages 521-539
Chronic Liver Disease in the Intensive Care....Pages 541-559
Back Matter....Pages 561-588
