Chromosome Structural Analysis: A Practical Approach (The Practical Approach Series, 200)

In eukaryotes, DNA is packaged in chromosomes, the structure and number of which provide a great deal of information for many aspects of cellular genetics. This hands-on guide is an up-to-date survey of experimental methods for analyzing chromosome structure, and it includes techniques for vertebrates, Drosophila, yeast, and Xenopus. Organized in a methodical fashion, the book begins with the analysis of chromatin and protein mapping, followed by chapters on whole chromosome structure, then on whole-mount tissues and the analysis of sub-structure in mammals, and concluding with two chapters on the experimental manipulation of chromosome structure. With over 70 protocols, the book will be invaluable for a wide range of researchers in genetics, medicine, and molecular biology.