Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance in both animal and human biology. This book contains 22 chapters, dealing in depth with structural and functional aspects of the currently known and extremely diverse unrelated families of cholesterol-binding and cholesterol transport proteins. By drawing together this range of topics the Editor has attempted to correlate this broad field of study for the first time. Technical aspects are given considerable emphasis, particularly in relation cholesterol reporter molecules and to the isolation and study of membrane cholesterol- and sphingomyelin-rich "raft" domains. Cell biological, biochemical and clinical topics are included in this book, which serve to emphasize the acknowledged and important benefits to be gained from the study of cholesterol and cholesterol-binding proteins within the biomedical sciences and the involvement of cholesterol in several clinical disorders.
It is hoped that by presenting this topic in this integrated manner that an appreciation of the fact that there is much more that needs to be taken into account, studied and understood than the widely discussed "bad and good cholesterol" associated, respectively, with the low- and high-density lipoproteins, LDL and HDL.
Author(s): Gerald Gimpl (auth.), J. Robin Harris (eds.)
Series: Subcellular Biochemistry 51
Edition: 1
Publisher: Springer Netherlands
Year: 2010
Language: English
Pages: 632
Tags: Biochemistry, general; Lipidology; Protein Science; Apoptosis; Animal Biochemistry
Front Matter....Pages i-xxi
Cholesterol–Protein Interaction: Methods and Cholesterol Reporter Molecules....Pages 1-45
Cholesterol in Alzheimer’s Disease and other Amyloidogenic Disorders....Pages 47-75
Cholesterol-Binding Viral Proteins in Virus Entry and Morphogenesis....Pages 77-108
Sterol–Protein Interactions in Cholesterol and Bile Acid Synthesis....Pages 109-135
Cholesterol Oxidase: Structure and Function....Pages 137-158
Oxysterol-Binding Proteins....Pages 159-182
High Density Lipoprotein Structure–Function and Role in Reverse Cholesterol Transport....Pages 183-227
Lipoprotein Modification and Macrophage Uptake: Role of Pathologic Cholesterol Transport in Atherogenesis....Pages 229-251
Cholesterol Interaction with Proteins That Partition into Membrane Domains: An Overview....Pages 253-278
Caveolin, Sterol Carrier Protein-2, Membrane Cholesterol-Rich Microdomains and Intracellular Cholesterol Trafficking....Pages 279-318
Cholesterol in Niemann–Pick Type C disease....Pages 319-335
Protein Mediators of Sterol Transport Across Intestinal Brush Border Membrane....Pages 337-380
Cholesterol at the Endoplasmic Reticulum: Roles of the Sigma-1 Receptor Chaperone and Implications thereof in Human Diseases....Pages 381-398
Prominin-1: A Distinct Cholesterol-Binding Membrane Protein and the Organisation of the Apical Plasma Membrane of Epithelial Cells....Pages 399-423
Mammalian StAR-Related Lipid Transfer (START) Domains with Specificity for Cholesterol: Structural Conservation and Mechanism of Reversible Binding....Pages 425-437
Membrane Cholesterol in the Function and Organization of G-Protein Coupled Receptors....Pages 439-466
Cholesterol Effects on Nicotinic Acetylcholine Receptor: Cellular Aspects....Pages 467-487
Cholesterol and Myelin Biogenesis....Pages 489-508
Cholesterol and Ion Channels....Pages 509-549
The Cholesterol-Dependent Cytolysin Family of Gram-Positive Bacterial Toxins....Pages 551-577
Cholesterol Specificity of Some Heptameric β-Barrel Pore-Forming Bacterial Toxins: Structural and Functional Aspects....Pages 579-596
Cholesterol-Binding Toxins and Anti-cholesterol Antibodies as Structural Probes for Cholesterol Localization....Pages 597-621
Back Matter....Pages 623-631
