Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development.
The first part of the book deals with the chemistry, biochemistry, physiology and toxicity of oxygen, including chapters on hemoglobin reactivity and regulation; the major cellular and physiological control mechanisms of blood flow and oxygen delivery; hemoglobin and myoglobin; nitric oxide and oxygen; and the role of reactive oxygen and nitrogen species in ischemia/reperfusion Injury.
The book then discusses medical needs for oxygen supply, including acute traumatic hemorrhage and anemia; diagnosis and treatment of haemorrhages in "non-surgical" patients; management of perioperative bleeding; oxygenation in the preterm neonate; ischemia
normobaric and hyperbaric oxygen therapy for ischemic stroke and other neurological conditions; and transfusion therapy in ? thalassemia and sickle cell disease
Finally “old”and new strategies for oxygen supply are described. These include the political, administrative and logistic issues surrounding transfusion; conscientious objection in patient blood management; causes and consequences of red cell incompatibility; biochemistry of red blood cell storage; proteomic investigations on stored red blood cells; red blood cells from stem cells; the universal red blood cell; allosteric effectors of hemoglobin; hemoglobin-based oxygen carriers; oxygen delivery by natural and artificial oxygen carriers; cross-linked and polymerized hemoglobins as potential blood substitutes; design of novel pegylated hemoglobins as oxygen carrying plasma expanders; hb octamers by introduction of surface cysteines; hemoglobin-vesicles as a cellular type hemoglobin-based oxygen carrier; animal models and oxidative biomarkers to evaluate pre-clinical safety of extracellular hemoglobins; and academia – industry collaboration in blood substitute development.
Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood is an essential reference for clinicians, haematologists, medicinal chemists, biochemists, molecular biologists, biotechnologists and blood substitute researchers.Content:
Chapter 1 Introduction (pages 1–7): Richard B. Weiskopf
Chapter 2 Hemoglobin Reactivity and Regulation (pages 9–22): Stefano Bettati and Andrea Mozzarelli
Chapter 3 The Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery (pages 23–45): Raymond C. Koehler
Chapter 4 The Main Players: Hemoglobin and Myoglobin; Nitric Oxide and Oxygen (pages 47–62): Tim J. McMahon and Joseph Bonaventura
Chapter 5 The Role of Reactive Oxygen and Nitrogen Species in Ischemia/Reperfusion Injury (pages 63–77): Ester Spagnolli and Warren M. Zapol
Chapter 6 Acute Traumatic Hemorrhage and Anemia (pages 79–106): Lena M. Napolitano
Chapter 7 Diagnosis and Treatment of Haemorrhages in ‘Nonsurgical’ Patients (pages 107–119): Umberto Rossi and Rosa Chianese
Chapter 8 Management of Perioperative Bleeding (pages 121–130): Sibylle A. Kozek?Langenecker
Chapter 9 Oxygenation in the Preterm Neonate (pages 131–143): Vidheya Venkatesh, Priya Muthukumar, Anna Curley and Simon Stanworth
Chapter 10 Ischemia (pages 145–158): Hooman Mirzakhani and Ala Nozari
Chapter 11 Normobaric and Hyperbaric Oxygen Therapy for Ischemic Stroke and Other Neurological Conditions (pages 159–177): Ari Moskowitz, Yu?Feng Yvonne Chan and Aneesh B. Singhal
Chapter 12 Transfusion Therapy in ? Thalassemia and Sickle Cell Disease (pages 179–191): Carlo Brugnara and Lucia De Franceschi
Chapter 13 Transfusion: Political, Administrative and Logistic Issues (pages 193–204): John R. Hess and Giuliano Grazzini
Chapter 14 Conscientious Objection in Patient Blood Management (pages 205–211): Kenneth E. Nollet and Hitoshi Ohto
Chapter 15 Red?Cell Transfusion in Clinical Practice (pages 213–220): Harvey G. Klein
Chapter 16 Causes and Consequences of Red Cell Incompatibility (pages 221–230): Chisa Yamada and Robertson Davenport
Chapter 17 Biochemistry of Storage of Red Blood Cells (pages 231–241): Ryan Stapley, Dario A. Vitturi and Rakesh P. Patel
Chapter 18 Proteomic Investigations of Stored Red Blood Cells (pages 243–256): Lello Zolla and Angelo D'Alessandro
Chapter 19 Red Blood Cells from Stem Cells (pages 257–271): Anna Rita Migliaccio, Carolyn Whitsett and Giovanni Migliaccio
Chapter 20 The Universal Red Blood Cell (pages 273–284): Luca Ronda and Serena Faggiano
Chapter 21 Allosteric Effectors of Hemoglobin: Past, Present and Future (pages 285–300): Martin K. Safo and Stefano Bruno
Chapter 22 Hemoglobin?Based Oxygen Carriers: History, Limits, Brief Summary of the State of the Art, Including Clinical Trials (pages 301–316): Jonathan S. Jahr, Arezou Sadighi, Linzy Doherty, Alvin Li and Hae Won Kim
Chapter 23 Oxygen Delivery by Natural and Artificial Oxygen Carriers (pages 317–325): Enrico Bucci
Chapter 24 Crosslinked and Polymerized Hemoglobins as Potential Blood Substitutes (pages 327–344): Kenneth W. Olsen and Eugene Tarasov
Chapter 25 Engineering the Molecular Shape of PEG?Hemoglobin Adducts for Supraperfusion (pages 345–369): Seetharama A. Acharya, Marcos Intaglietta, Amy G. Tsai, Kulal Ananda and Fantao Meng
Chapter 26 Hb Octamers by Introduction of Surface Cysteines (pages 371–380): Veronique Baudin?Creuza, Chien Ho and Michael C. Marden
Chapter 27 Hemoglobin Vesicles as a Cellular?Type Hemoglobin?Based Oxygen Carrier (pages 381–390): Hiromi Sakai, Hirohisa Horinouchi, Eishun Tsuchida and Koichi Kobayashi
Chapter 28 Animal Models and Oxidative Biomarkers to Evaluate Preclinical Safety of Extracellular Hemoglobins (pages 391–411): Paul W. Buehler and Felice D'Agnillo
Chapter 29 Academia–Industry Collaboration in Blood Substitute Development: Issues, Case Histories and a Proposal (pages 413–428): Hae Won Kim, Andrea Mozzarelli, Hiromi Sakai and Jonathan S. Jahr