Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.
This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 19th volume of a continuing series.
Author(s): Kursad Turksen
Series: Advances in Experimental Medicine and Biology, 1410
Publisher: Springer
Year: 2023
Language: English
Pages: 195
City: Cham
Preface
Contents
Monkeypox and Sexually Transmitted Diseases
1 Introduction
2 Sexual Transmission of Monkeypox
3 Monkeypox and HIV Infection
4 Monkeypox and Syphilis
5 Monkeypox and Gonorrhea
6 Monkeypox and Chlamydia Infection
7 Monkeypox and Herpes Simplex Type 2 Infection
8 Monkeypox and Genital Wart
9 Conclusion
References
Clinical Manifestations of Monkeypox
1 Introduction
2 Dermatological Manifestations
3 Other Clinical Manifestations
3.1 Respiratory Symptoms
3.2 Triggering the Second-Line Immune System
3.3 Myalgia and Backache
3.4 Encephalitis
3.5 Gastrointestinal Symptoms
3.6 Ocular Symptoms
4 Management of Monkeypox
5 Conclusion
References
Laboratory Diagnosis for Monkeypox: Clinical Practice and Important Points to Be Recognized
1 Introduction to Monkeypox
2 Diagnosing Monkeypox in Clinical Practice
2.1 Clinical History
2.2 Physical Examination Findings
2.3 Laboratory Diagnosis
3 Quality Management for Laboratory Diagnosis for Monkeypox Diagnosis
References
Regulatory Mechanisms of Muscle Mass: The Critical Role of Resistance Training in Children and Adolescent
1 Introduction
2 Cellular Mechanisms of Muscle Development and Growth
3 Neural Control of Muscular Mass
4 Endocrine Regulators of Muscle Mass and Strength
4.1 Growth Hormone and IGF-1
4.2 Testosterone
4.3 Thyroid Hormones
4.4 Glucocorticoids
4.5 Adaptations in Muscle Mass and Strength in Children and Adolescents Following Resistance Training
4.6 Benefits of Resistance Training
4.7 Concerns and Risks of Resistance Training
5 Conclusion
References
HSF1 and Its Role in Huntington´s Disease Pathology
1 Summary
2 Introduction
3 Introduction to Heat Shock Factor 1
3.1 HSF1: Structure, Function, and Regulation
3.2 HSF1 PTMs: Pathophysiological Implications
4 Regulation of HSF1 and the HSR by Non-coding RNAs
5 Role of HSF1 in Physiology and Disease
5.1 HSF1 in Aging and Inflammation
5.2 Tumorigenesis and HSF1
5.3 HSF1 in the Central Nervous System (CNS)
5.4 Neurodegenerative Diseases and HSF1
6 Protein Aggregation in HD
6.1 Structure and Function of HTT
6.2 HSR and Other Protein Quality Control Systems in HD
7 Implication of HSF1 in HD
7.1 HSF1 and Hsp Function in HD
7.2 Crosstalk Between HSF1 and the UPS: Implications in HD
7.3 PolyQ-Induced Oxidative and Metabolic Stress: Convergence into HSF1
7.4 HSF1 as a Potential Regulator of PolyQ-Dependent Mitochondrial Dysfunction
7.4.1 Mitochondrial Dysfunction and Excitotoxicity
7.5 Crosstalk Between HSF1 and Mitochondrial-Mediated Apoptotic Pathways
7.6 Excitatory Synapse Regulation in HD; Connection Between HSF1 and Mitochondrial Dysfunction
7.7 Role of HSF1 in Other PolyQ-Related Diseases
8 HSF1 as a Therapeutic Target in HD and Other PolyQ Diseases
9 Conclusion
References
Leveraging Tissue Engineering for Skin Cancer Models
1 Introduction
2 Skin Cancer Models
2.1 Melanoma Skin Model
2.2 Squamous Cell Carcinoma (SCC) Skin Model
2.3 Basal Cell Carcinoma (BCC) Skin Model
3 Discussion and Conclusion
References
Application of Drug Repurposing-Based Precision Medicine Platform for Leukaemia Patient Treatment
1 Introduction
2 Characteristics of Leukaemia Subtypes and Influence on Therapy
2.1 Lymphocytic Leukaemia
2.2 Myeloid Leukaemia
3 The Case for Drug Repurposing
4 The Link Between Precision Medicine and Drug Screening
5 Drug Screening Platforms
5.1 Microfluidic Platforms
5.2 Virtual Drug Screening Platform
5.3 Pre-Clinical Models of Drug Screening
6 Clinical Evidence for Drug Repurposing
7 Conclusion and Future Directions
References
Stem Cell-Derived Extracellular Vesicles as a Potential Therapeutic Tool for Eye Diseases: From Benchtop to Bedside
1 Background
2 Application of EVs in Ocular Disorders
2.1 Pre-clinical Applications
2.1.1 Corneal Disorders
2.1.2 Dry Eye Disease
2.1.3 Uveal Disorders
2.1.4 Glaucoma
2.1.5 Retinal Disorders
2.2 Clinical Applications
3 Obstacles on the Way
3.1 Contamination
3.2 Recycled MSCs
3.3 Insufficient Yield
3.4 Bacterial Infection
4 Concluding Remarks
References
Cannabinoids as Prospective Anti-Cancer Drugs: Mechanism of Action in Healthy and Cancer Cells
1 Introduction
2 Focus on Cannabinoids
2.1 Phytocannabinoids
2.2 The Endocannabinoid System (ECS)
2.3 Synthetic Cannabinoids
2.4 Cannabinoids in Healthy Vs Cancer Cell Behavior
2.4.1 Cannabinoids in Cell Proliferation
2.4.2 Cannabinoids in Cell Migration, Invasion, and Angiogenesis
2.4.3 Cannabinoids in Cell Autophagy and Death
2.5 Preclinical In Vivo Studies and Clinical Status of Cannabinoids
3 Future Perspectives for Cannabinoids as Prospective Agents for Cancer
References
Direct Reprogramming of Somatic Cells into Induced β-Cells: An Overview
1 Introduction
2 Liver Cells to β-Cells
3 Endocrine Cells to β-Cells
4 Exocrine Cells to β-Cells
4.1 Acinar Cells
4.2 Ductal Cells
5 Conclusion
References
Index
