In this book, experts in the field express their well-reasoned opinions on a range of complex, clinically relevant issues across the full spectrum of cell and gene therapies with the aim of providing trainee and practicing hematologists, including hematopoietic transplant physicians, with information that is relevant to clinical practice and ongoing research. Each chapter focuses on a particular topic, and the concise text is supported by numerous working tables, algorithms, and figures. Whenever appropriate, guidance is provided regarding the availability of potentially high-impact clinical trials. The rapid evolution of cell and gene therapies is giving rise to numerous controversies that need to be carefully addressed. In meeting this challenge, this book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients. It will also offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee.
Author(s): Miguel-Angel Perales, Syed A. Abutalib, Catherine Bollard
Series: Advances and Controversies in Hematopoietic Transplantation and Cell Therapy
Publisher: Springer
Year: 2019
Language: English
Pages: 286
Front Matter ....Pages i-vi
Historical Perspective and Current Focus (Miguel-Angel Perales, Catherine Bollard)....Pages 1-2
Most Recent Clinical Advances in CAR T Cell and Gene Therapy 2017/2018 (Syed A. Abutalib, Saar I. Gill)....Pages 3-24
Front Matter ....Pages 25-25
Chimeric Antigen Receptor T Cells: Antigen Selection, CAR Development, and Data in Neoplastic Hematology (Januario E. Castro, Thomas J. Kipps)....Pages 27-53
Chimeric Antigen Receptor T Cells for Leukemias in Children: Methods, Data, and Challenges (Mala K. Talekar, Stephan A. Grupp)....Pages 55-73
Chimeric Antigen Receptor-T Cells for Leukemias in Adults: Methods, Data and Challenges (Mark B. Geyer, Jae H. Park, Renier J. Brentjens)....Pages 75-92
Chimeric Antigen Receptor T Cells for Lymphomas: Methods, Data, and Challenges (Yakup Batlevi, Craig S. Sauter)....Pages 93-108
T Cell Receptors-Gene-Modified T Cells for Cancer: Methods, Data, and Challenges (Aaron P. Rapoport, Jean A. Yared)....Pages 109-133
Front Matter ....Pages 135-135
Cytotoxic T Cells for Infections: From Donor Specific to “Off the Shelf” (Maria A. V. Marzolini, Karl S. Peggs)....Pages 137-157
Regulatory T Cells: Broadening Applicability (Franziska Maria Uhl, Robert Zeiser)....Pages 159-177
Front Matter ....Pages 179-179
Natural Killer Cells: What Have We Learned? (Dhifaf Sarhan, Jeffery S. Miller)....Pages 181-200
Dendritic Cells in Hematopoietic Cell Transplantation (David J. Chung)....Pages 201-218
Mesenchymal Stem Cells: From Bench to Bedside and Back (John Barrett, Jacques Galipeau)....Pages 219-242
Front Matter ....Pages 243-243
Gene Therapy for Neoplastic Hematology in Transplant Setting (Januario E. Castro, Thomas J. Kipps)....Pages 245-264
Gene Therapy for Nonmalignant Hematology (Xiuyan Wang, Isabelle Rivière)....Pages 265-288
