In 1993, Rolf Bodmer described a gene he named tinman that was required for the formation of the dorsal aorta of the fly. Flies without a functional tinman gene had no heart. Quickly, mammalian counterparts of the tinman gene were identified and found to be expressed by early cardiomyogenic precursors and by cardiomyocytes throughout heart development. Since then, significant progress has been made in the understanding of molecular and genetic determinants of heart formation. An ever growing number of genes have been identified that are required for cardiogenesis, as evidenced by severe abnormalities in cardiac development produced by inactivation in the mouse or inhibition of gene function in other model organisms. Cardiovascular Development covers some of the latest research in the study of heart formation. Volume Editor Rolf Bodmer has assembled a world-class list of contributors whose research uses a variety of animal models and whose findings are certain to enhance our understanding of this exciting field. * Ties together the development of heart morphology and conduction system * The latest developments in vertebrate and invertebrate genetic model systems * Technological advancements in cardiovascular science
Author(s): Rolf Bodmer (Eds.)
Series: Advances in Developmental Biology 18
Edition: 1
Publisher: Elsevier Science
Year: 2007
Language: English
Pages: 1-437
Content:
Heart Development in Drosophila Review Article
Pages 1-29
Li Qian, Jiandong Liu, Rolf Bodmer
Morphogenesis of the Vertebrate Heart Review Article
Pages 31-68
Willem M.H. Hoogaars, Vincent M. Christoffels, Antoon F.M. Moorman
Heart Development and T‐box Transcription Factors: Lessons from Avian Embryos Review Article
Pages 69-91
Elaine L. Shelton, Katherine E. Yutzey
Transcriptional Control of Cardiac Boundary Formation Review Article
Pages 93-115
Anabel Rojas, Brian L. Black
Signaling Pathways in Embryonic Heart Induction Review Article
Pages 117-151
Rosa M. Guzzo, Ann C. Foley, Yessenia M. Ibarra, Mark Mercola
Islet1 Progenitors in Developing and Postnatal Heart Review Article
Pages 153-165
Yunfu Sun, Xingqun Liang, Sylvia M. Evans
Role of microRNAs in Cardiovascular Biology Review Article
Pages 167-178
Eva Samal, Deepak Srivastava
Divergent Roles of Hedgehog and Fibroblast Growth Factor Signaling in Left–Right Development Review Article
Pages 179-201
Judith M. Neugebauer, H. Joseph Yost
Development of the Conduction System: Picking up the Pace Review Article
Pages 203-218
Dina Myers Stroud, Gregory E. Morley
Transcriptional Control of the Cardiac Conduction System Review Article
Pages 219-258
Shan‐Shan Zhang, Benoit G. Bruneau
Genetic Dissection of Hematopoiesis Using Drosophila as a Model System Review Article
Pages 259-299
Cory J. Evans, Sergey A. Sinenko, Lolitika Mandal, Julian A. Martinez‐Agosto, Volker Hartenstein, Utpal Banerjee
Vascular Development in the Zebrafish Review Article
Pages 301-332
Josette Ungos, Brant M. Weinstein
Development and Function of the Epicardium Review Article
Pages 333-357
Jörg Männer, Pilar Ruiz‐Lozano
Genetics of Transcription Factor Mutations Review Article
Pages 359-377
Vijaya Ramachandran, D. Woodrow Benson
Human Genetics of Congenital Heart Disease Review Article
Pages 379-417
Jeffrey A. Towbin
Contributors to Volume 18
Pages XI-XIV
Preface
Pages XV-XVI
Rolf Bodmer
Subject Index
Pages 419-437
Table of Contents
Pages V-IX
Series Editors
Page II
