During the last decades progress has been made in the treatment of patients who survived myocardial infarction. Nevertheless, patients who survive an acute myocardial infarction are at high risk, with life expectancy half that of their peers who have not experienced similar events, and with increased risk for subsequent cardiovascular events and death. The risk of sudden death increases with severity of systolic dysfunction after myocardial infarction. In recent years, it has become clear that in addition to risk factors such as overweight, lack of exercise, smoking, hypertension and hypercholesterolemia, psychosocial factors play a key role for prognosis in patients with myocardial infarction. Therefore, there is high medical need for drugs which lower the incidence of sudden death and have an effect on other risk factors such as depression. OMACOR?‚?®, a pharmaceutical preparation of highly purified and concentrated Omega-3 polyunsaturated acids, may present such a drug. It lowers the incidence of sudden death in patients with myocardial infarction and decreases depression. This publication focuses on the effect of Omega-3 polyunsaturated fatty acids on different risk factors in patients with cardiovascular disease. In addition, aspects of prevention of cardiovascular disease, risk factors and pharmacokinetics of Omega-3 fatty acids ethyl esters are considered.IOS Press is an international science, technical and medical publisher of high-quality books for academics, scientists, and professionals in all fields. Some of the areas we publish in: -Biomedicine -Oncology -Artificial intelligence -Databases and information systems -Maritime engineering -Nanotechnology -Geoengineering -All aspects of physics -E-governance -E-commerce -The knowledge economy -Urban studies -Arms control -Understanding and responding to terrorism -Medical informatics -Computer Sciences
Author(s): B. Maisch; R. Oelze
Edition: 1
Year: 2007
Language: English
Pages: 196
Title page......Page 1
Preface......Page 5
List of Contributors......Page 7
Contents......Page 9
Conference Preface......Page 13
Keynote Lecture - Risk Factors for Atherosclerotic Disease: Present and Future......Page 17
Microdetermination of Fatty Acids by Gas Chromatography and Cardiovascular Risk Stratification by the "EPA+DHA Level"......Page 57
Highly Purified Omega-3 Polyunsaturated Fatty Acids Are Effective as Adjunct Therapy for Secondary Prevention of Myocardial Infarction: Critical Analysis of GISSI-Prevenzione Trial......Page 91
Prevention of Cardiovascular Diseases and Highly Concentrated n-3 Polyunsaturated Fatty Acids (PUFAs)......Page 109
Omega-3 Fatty Acids and Sudden Arrhythmic Death......Page 121
Depression and Coronary Artery Disease: Epidemiology and Potential Mechanisms......Page 131
Effects of Omega-3 Polyunsaturated Fatty Acids on Depression......Page 139
A Multi-Country Health-Economic Evaluation of Highly Concentrated n-3 Polyunsaturated Fatty Acids (PUFAs) in the Secondary Prevention After Myocardial Infarction (MI)......Page 149
OMACOR® in Clinical Development: A Survey of Current Trials......Page 165
Author Index......Page 195