Accelerated cardiovascular disease is a frequent complication of chronic kidney disease. Individuals with evidence of renal functional impairment are more likely to die of cardiovascular events than to progress to end stage renal disease.
This relationship, which has been termed the cardiorenal syndrome, exists whether impairment of renal function is a consequence of primary renal parenchymal or primary heart disease.
The mechanisms underlying the cardiorenal syndrome result from a complex interaction of traditional and uremia related cardiovascular risk factors. Prevention and management of cardiovascular disease include aggressive control of traditional risk factors as well novel approach to prevent or reverse uremia related processes.
Chronic kidney disease with a worldwide prevalence of 10% in the general population is emerging as a major public health priority. Renal dysfunction is associated with a high risk for cardiovascular complications. The relationship between renal insufficiency and cardiovascular disease, termed the cardiorenal syndrome exists whether impairment of renal function is a consequence of primary renal parenchymal disease or primary heart disease.
This book provides a comprehensive update analysis of our current understanding of the cardiorenal syndrome, including epidemiology, pathophysiologic mechanisms, and therapeutic approaches.
Author(s): Adel E. Berbari (auth.), Adel E. Berbari, Giuseppe Mancia (eds.)
Edition: 1
Publisher: Springer-Verlag Mailand
Year: 2010
Language: English
Pages: 396
Tags: Cardiology; Nephrology
Front Matter....Pages i-xv
Front Matter....Pages 1-1
Links between Chronic Kidney Disease and Cardiovascular Disease: A Bidirectional Relationship....Pages 3-14
Cardiorenal versus Renocardiac Syndrome....Pages 15-34
Front Matter....Pages 35-35
Non-Pressure-Related Deleterious Effects of Excessive Dietary Sodium....Pages 37-47
Regulation of Vascular and Renal Cells by Common Mediators in Health and Disease: Role of the Renin—Angiotensin System in the Pathophysiology of Hypertension and Cardiovascular Disease....Pages 49-63
Front Matter....Pages 65-65
Cardiorenal Continuum....Pages 67-79
Definition and Classification of Stages of Chronic Kidney Disease: Screening for Chronic Kidney Disease....Pages 81-89
Cardiovascular Disease Risk Factors in Chronic Kidney Disease: Traditional, Nontraditional, and Uremia-related Threats....Pages 91-104
Increased Levels of Urinary Albumin: A Cardiovascular Risk Factor and a Target for Treatment....Pages 105-116
Microalbuminuria and Kidney Disease: An Evidence-based Perspective....Pages 117-130
Cardiometabolic Syndrome....Pages 131-144
Diabetes Mellitus: Is the Presence of Nephropathy Important as a Cardiovascular Risk Factor for Cardioneral Syndrome?....Pages 145-157
Front Matter....Pages 159-159
Cardiovascular Disease: Coronary Artery Disease and Coronary Artery Calcification....Pages 161-173
Cardiomyopathy in Chronic Kidney Disease and in End-stage Renal Disease....Pages 175-187
Pathophysiological Mechanisms and Prognostic Significance of Renal Functional Impairment in Cardiac Patients....Pages 189-203
Stroke....Pages 205-215
Front Matter....Pages 217-217
Uremic Toxins....Pages 219-234
Endothelial Dysfunction, Nitric Oxide Bioavailability, and Asymmetric Dimethyl Arginine....Pages 235-244
Pathophysiologic Link between Atherosclerosis and Nephrosclerosis....Pages 245-253
Aortic Stiffness, Kidney Disease, and Renal Transplantation....Pages 255-267
Disturbed Calcium-Phosphorus Metabolism/Arterial Calcifications: Consequences on Cardiovascular Function and Clinical Outcome....Pages 269-277
Front Matter....Pages 217-217
Role of Neurohormonal Activation in the Pathogenesis of Cardiovascular Complications in Chronic Kidney Disease....Pages 279-290
Impaired Autonomic Blood Pressure and Blood Volume Control in Chronic Renal Failure....Pages 291-297
Role of Novel Biomarkers in Chronic Kidney Disease: Urotensin II....Pages 299-308
Role of Novel Biomarkers in Chronic Kidney Disease: Renalase....Pages 309-316
Front Matter....Pages 317-317
Diabetic Kidney Disease....Pages 319-339
Nondiabetic Kidney Disease....Pages 341-356
Front Matter....Pages 357-357
Approaches in the Management of Patients with Chronic Kidney Disease and Cardiovascular Disease....Pages 359-369
Trends in the Management of Cardiac Patients with Renal Functional Impairment....Pages 371-386
Back Matter....Pages 387-396
