Biomedical, pharmaceutical and medical personnel are interested in studying aspects of arrhythmias at a basic, translational and applied level. The overall understanding of the molecular basis of disease has dramatically increased, as well as the number of available and emerging molecular, pharmacological and device treatment based therapies. Cardiac Electrophysiology Methods and Models will review key research methods and protocols in cardiac electrophysiology with a focus on advantages, pitfalls, practical implementation and collaborative cross-functional research.
Author(s): David G. Benditt, Scott Sakaguchi, MaryAnn Goldstein, Richard Sutton (auth.), Daniel C. Sigg, Paul A. Iaizzo, Yong-Fu Xiao, Bin He (eds.)
Edition: 1
Publisher: Springer US
Year: 2010
Language: English
Pages: 492
Tags: Cardiology
Front Matter....Pages i-xiv
Front Matter....Pages 39-39
Clinical Cardiac Electrophysiology: An Overview of Its Evolution....Pages 1-38
Front Matter....Pages 39-39
Basic Cardiac Electrophysiology: Excitable Membranes....Pages 41-51
Cardiac Action Potentials, Ion Channels, and Gap Junctions....Pages 53-72
Anatomy and Physiology of the Cardiac Conduction System....Pages 73-89
The Electrocardiogram and Clinical Cardiac Electrophysiology....Pages 91-116
Front Matter....Pages 117-117
Principles of Electrophysiological In Vitro Measurements....Pages 119-134
Cardiac Cellular Electrophysiological Modeling....Pages 135-158
Computer Modeling of Electrical Activation: From Cellular Dynamics to the Whole Heart....Pages 159-185
Detection and Measurement of Cardiac Ion Channels....Pages 187-212
Cell Culture Models and Methods....Pages 213-235
Isolated Tissue Models....Pages 237-247
Isolated Heart Models....Pages 249-260
Small Animal Models for Arrhythmia Studies....Pages 261-279
Use of Large Animal Models for Cardiac Electrophysiology Studies....Pages 281-304
Optical Mapping and Calcium Imaging....Pages 305-327
Electrophysiology of Single Cardiomyocytes: Patch Clamp and Other Recording Methods....Pages 329-348
Invasive Electroanatomical Mapping and Navigation....Pages 349-356
Cardiac Electrophysiological Imaging: Solving the Inverse Problem of Electrocardiography....Pages 357-373
Traditional Electrophysiological Mapping....Pages 375-393
Multi-channel System for Analysis of Cardiac Rhythmicity and Conductivity In Vitro....Pages 395-417
Front Matter....Pages 117-117
Cardiac CT/MRI Imaging for Electrophysiology....Pages 419-437
Front Matter....Pages 439-439
Introduction to Translational Research....Pages 441-455
Clinical Perspective: Electrophysiology in the Young and Patients with Congenital Heart Disease....Pages 457-477
Back Matter....Pages 479-491
