This teaching monograph on systems approaches to cancer research and clinical applications provides a unique synthesis, by world-class scientists and doctors, of laboratory, computational, and clinical methods, thereby establishing the foundations for major advances not possible with current methods. Specifically, the book: 1) Sets the stage by describing the basis of systems biology and bioinformatics approaches, and the clinical background of cancer in a systems context; 2) Summarizes the laboratory, clinical, data systems analysis and bioinformatics tools, along with infrastructure and resources required; 3) Demonstrates the application of these tools to cancer research; 4) Extends these tools and methods to clinical diagnosis, drug development and treatment applications; and 5) Finishes by exploring longer term perspectives and providing conclusions. This book reviews the state-of-the-art, and goes beyond into new applications. It is written and highly referenced as a textbook and practical guide aimed at students, academics, doctors, clinicians, industrialists and managers in cancer research and therapeutic applications. Ideally, it will set the stage for integration of available knowledge to optimize communication between basic and clinical researchers involved in the ultimate fight against cancer, whatever the field of specific interest, whatever the area of activity within translational research.
Author(s): Dr. Frederick B. Marcus D.Phil (Oxford), Dr. Alfredo Cesario MD (auth.), Alfredo Cesario, Frederick Marcus (eds.)
Edition: 1
Publisher: Springer Netherlands
Year: 2011
Language: English
Pages: 484
Tags: Cancer Research; Systems Biology; Oncology; Medical Microbiology; Computational Biology/Bioinformatics
Front Matter....Pages 1-1
Front Matter....Pages 1-1
Introduction to Systems Approaches to Cancer....Pages 3-27
Cancer: Clinical Background and Key Challenges....Pages 29-93
Front Matter....Pages 95-95
Global Molecular and Cellular Measurement Technologies....Pages 97-126
Cell Lines, Tissue Samples, Model Organisms, and Biobanks: Infrastructure and Tools for Cancer Systems Biology....Pages 127-152
Expression and Genetic Variation Databases for Cancer Research....Pages 153-164
Education and Research Infrastructures....Pages 165-181
Front Matter....Pages 183-183
Mathematical Tools in Cancer Signalling Systems Biology....Pages 185-212
Computational Tools for Systems Biology....Pages 213-243
The Hallmarks of Cancer Revisited Through Systems Biology and Network Modelling....Pages 245-266
Systems Biology Analysis of Cell Death Pathways in Cancer: How Collaborative and Interdisciplinary Research Helps....Pages 267-296
Systems Biology, Bioinformatics and Medicine Approaches to Cancer Progression Outcomes....Pages 297-307
System Dynamics at the Physiological and Tumour Level....Pages 309-326
Front Matter....Pages 327-327
Diagnostic and Prognostic Cancer Biomarkers: From Traditional to Systems Approaches....Pages 329-366
Systems Biology Approaches to Cancer Drug Development....Pages 367-380
Circadian Rhythms and Cancer Chronotherapeutics....Pages 381-407
Clinical Applications of Systems Biology Approaches....Pages 409-428
Cancer Robustness and Therapy Strategies....Pages 429-446
Front Matter....Pages 447-447
Synthetic Biology and Perspectives....Pages 449-469
Conclusions....Pages 471-477
Back Matter....Pages 467-467
