A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.
Author(s): David T. Curiel, Joanne T. Douglas
Series: Contemporary cancer research
Edition: 1
Publisher: Humana Press
Year: 2005
Language: English
Commentary: 64291
Pages: 502
City: Totowa, N.J
Cover......Page 1
Preface......Page 6
Contents......Page 8
Contributors......Page 10
1 Cancer Gene Therapy: Historical Perspective......Page 14
2 The Genetic Basis of Cancer......Page 22
3 Tumor Suppressor Gene Replacement for Cancer......Page 32
4 Antisense Technology......Page 48
5 Cancer Therapeutic Applications of Ribozymes and RNAi......Page 64
6 Fusogeneic Membrane Glycoproteins for Cancer Gene Therapy:......Page 78
7 Suicide Gene Therapy......Page 94
8 Molecular Chemotherapy Approaches......Page 122
9 Genetic Immunotherapy Approaches......Page 142
10 Immunotherapy of Cancer by Dendritic Cell-TargetedGene Transfer......Page 156
11 Dendritic Cells......Page 186
12 Polynucleotide Immunization for Cancer Therapy......Page 198
13 Development of Oncolytic Replication-CompetentHerpes Simplex Virus Vectors: The G207 Paradigm......Page 212
14 Development of Oncolytic Adenoviruses:......Page 224
15 Conditionally Replicating Adenoviruses for Cancer Treatment......Page 248
16 Reovirus as an Oncolytic Agent......Page 262
17 Antiangiogenic Gene Therapy of Cancer......Page 274
18 Proapoptotic Strategy in Cancer Gene Therapy......Page 286
19 Antimetastasis......Page 300
20 Antimetastatic Gene Therapy: Prostate Cancer Theory to Therapy......Page 312
21 Drug Resistance Gene Transfer as an Antitumor Strategy......Page 334
22 Chemosensitization......Page 348
23 Radiosensitization by Gene Therapy......Page 362
24 Nonviral Vector Systems for Cancer Gene Therapy......Page 380
25 Viral Vectors for Cancer Gene Therapy......Page 392
26 Bacterial Systems for Tumor-Specific Gene Therapy......Page 406
27 Molecular Imaging of Cancer Gene Therapy......Page 418
28 Cancer-Related Gene Therapy Clinical Trials......Page 440
29 Regulatory Aspects in the Development of Gene Therapies......Page 454
Index......Page 486
