The acknowledgment that viruses are potent biological factors in driving many cancers have seen a dramatic upsurge in recent years in large part to the success of the human papilloma virus vaccine against invasive cervical carcinomas and followed by the awarding of the noble prize in medicine in 2008 to Dr. Harald zurHausen who identified the link between papilloma virus and cervical cancers. Over the last few years there have been some volumes addressing different aspects of viruses and cancers and to some extent focusing on the DNA viruses, more specifically the human DNA viruses. This proposed volume will attempt to review and address the major gaps in current knowledge in DNA viruses as well as RNA viruses bringing a historical perspective of where studies began to a more recent molecular approach and vaccine successes in tumor viruses. We will also cover other known oncogenic viruses associated cancers in other mammals in addition to humans.
Author(s): Volker Wunderlich, Peter Kunze (auth.), Erle S. Robertson (eds.)
Series: Current Cancer Research
Edition: 1
Publisher: Springer-Verlag New York
Year: 2012
Language: English
Pages: 866
Tags: Cancer Research; Pharmacology/Toxicology
Front Matter....Pages i-xxiii
Peyton Rous: A Centennial Tribute to the Founding Father of Cancer Virology....Pages 1-23
Viruses and Cancer: A Historical Perspective – HBV and Prevention of a Cancer....Pages 25-43
Virus-Mediated Cell Proliferation....Pages 45-80
Viral-Encoded Genes and Cancer....Pages 81-99
Oncogenic Viruses and Cancer Transmission....Pages 101-118
DNA Viruses and Cancer: Taking a Broader Look....Pages 119-132
Herpesviruses and Cancer....Pages 133-167
Lymphocryptoviruses: EBV and Its Role in Human Cancer....Pages 169-199
Nonhuman Primate Gamma-herpesviruses and Their Role in Cancer....Pages 201-214
Rhadinoviruses: KSHV and Associated Malignancies....Pages 215-249
Retroperitoneal Fibromatosis Herpesvirus and Kaposi’s Sarcoma-Like Tumors in Macaques....Pages 251-266
Murine Gammaherpesvirus-Associated Tumorigenesis....Pages 267-305
Marek’s Disease Virus-Induced T-Cell Lymphomas....Pages 307-335
Polyomaviruses and Cancer....Pages 337-375
Polyomavirus SV40: Model Infectious Agent of Cancer....Pages 377-417
BK Polyomavirus and Transformation....Pages 419-432
Polyomavirus JC and Human Cancer: Possible Role of Stem Cells in Pathogenesis....Pages 433-448
Merkel Cell Polyomavirus....Pages 449-462
Human Papillomaviruses and Cancer....Pages 463-487
Tumorigenesis by Adenovirus Type 12 E1A....Pages 489-508
Overview of Hepatitis Viruses and Cancer....Pages 509-529
Hepadnaviruses and Hepatocellular Carcinoma....Pages 531-569
Hepatitis C Virus and Hepatocellular Carcinoma....Pages 571-583
Human and Animal Retroviruses: HIV-1 Infection Is a Risk Factor for Malignancy....Pages 585-611
HTLV-1 and Oncogenesis....Pages 613-645
Human T-Cell Leukemia Virus Type 2 (HTLV-2) Biology and Pathogenesis....Pages 647-675
Mechanisms of Oncogenesis by Avian and Murine Retroviruses....Pages 677-704
Rous Sarcoma Virus: Contributions of a Chicken Virus to Tumor Biology, Human Cancer Therapeutics, and Retrovirology....Pages 705-737
Mouse Mammary Tumor Virus and Cancer....Pages 739-753
Jaagsiekte Sheep Retrovirus and Lung Cancer....Pages 755-791
Small RNAs and Their Role in Herpesvirus-Mediated Cancers....Pages 793-817
Viral Malignancies in HIV-Associated Immune Deficiency....Pages 819-851
Back Matter....Pages 853-866
