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Brain Hypoxia and Ischemia: with Special Emphasis on Development

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Brain Hypoxia and Ischemia

Gabriel G. Haddad, M.D. and Shan Ping Yu, M.D., Ph.D., Editors

Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development.

This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice.

Gabriel G. Haddad, M.D. is Professor of Pediatrics and Neuroscience and Chair of the Department of Pediatrics at the University of California, San Diego. He is also Physician-in-Chief at Rady Children’s Hospital in San Diego.

Shan Ping Yu, M.D., Ph.D. is Professor of Anesthesiology at Emory University in Atlanta, GA.

Author(s): Jeremy D. Marks (auth.), Gabriel G. Haddad, Shan Ping Yu (eds.)
Series: Contemporary Clinical Neuroscience
Edition: 1
Publisher: Humana Press
Year: 2009

Language: English
Pages: 268
Tags: Neurosciences; Neurology; Neurobiology; Human Physiology

Front Matter....Pages i-xi
Regulation of Vulnerability to NMDA Excitotoxicity During Postnatal Maturation....Pages 3-24
Acidosis, Acid-Sensing Ion Channels, and Glutamate Receptor-Independent Neuronal Injury....Pages 25-41
Brain Ischemia and Neuronal Excitability....Pages 43-52
Critical Roles of the Na + /K + -ATPase in Apoptosis and CNS Diseases....Pages 53-78
Emerging Role of Water Channels in Regulating Cellular Volume During Oxygen Deprivation and Cell Death....Pages 79-96
A Zinc—Potassium Continuum in Neuronal Apoptosis....Pages 97-115
Mitochondrial Ion Channels in Ischemic Brain....Pages 117-150
Perinatal Panencephalopathy in Premature Infants: Is It Due to Hypoxia-Ischemia?....Pages 153-185
Effects of Intermittent Hypoxia on Neurological Function....Pages 187-212
Brainstem Sensitivity to Hypoxia and Ischemia....Pages 213-223
Matrix Metalloproteinases in Cerebral Hypoxia-Ischemia....Pages 225-238
Oxidative Stress in Hypoxic-Ischemic Brain Injury....Pages 239-254
Postnatal Hypoxia and the Developing Brain: Cellular and Molecular Mechanisms of Injury....Pages 255-276
Hypoxia-Inducible Factor 1....Pages 277-288
Transcriptional Response to Hypoxia in Developing Brain....Pages 289-306
Acute Stroke Therapy: Highlighting the Ischemic Penumbra....Pages 307-322
Genes and Survival to Low O 2 Environment: Potential Insights from Drosophila....Pages 323-333
Back Matter....Pages 335-343