A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage.
Author(s): Gurmit Singh, Shafaat A. Rabbani
Edition: 1
Publisher: Humana Press
Year: 2005
Language: English
Pages: 360
Cover......Page 1
Bonr Metastasis......Page 2
Cancer Drug Discovery and Development Series......Page 3
Title Page......Page 4
Copyright Page......Page 5
Dedication......Page 6
Preface......Page 7
Contents......Page 8
Contributors......Page 10
Part I. Fundamental Concepts......Page 13
1. Overview......Page 14
2. Parathyroid Hormone-Related Peptide and Malignancy......Page 24
3. Vitamin D and Vitamin D Analogs in Cancer Progression and Metastasis......Page 39
4. Role of TGF-β and IGF in Tumor Progression and Bone Metastases......Page 68
5. Biologic and Therapeutic Implications of Osteomimicry and Epithelial–Mesenchymal Transition in Prostate Cancer......Page 84
6. Roles of Immune-Cell-Derived Matrix Metalloproteinases in Tumor Growth and Metastasis......Page 96
7. Contribution of Osteopontin to the Development of Bone Metastasis......Page 116
8. Role of Interleukin-11 in Osteolytic Bone Metastasis......Page 133
9. Cell Adhesion Molecules in Tumor Metastasis......Page 141
10. PTHrP and Cancer:Prostate and Lung......Page 155
11.Antithrombotics in Tumor Growth and Metastasis......Page 184
Part II. Therapeutic Strategies......Page 195
12. Challenges and Strategies in the Analysis of Multiple Events in Oncology......Page 196
13. Integrins:Novel Targets for the Treatment of Bone Metastasis......Page 205
14. Bone Metastasis and Pathological Fractures:Bone Tissue Engineering as a Novel Therapy......Page 232
15. Role of Photodynamic Therapy for Bone Metastasis......Page 245
16. Docetaxel for Metastatic Cancer and Its Role in Combination Therapies for Advanced Prostate Cancer......Page 256
17. Use of Tetracyclines for Bone Metastases......Page 294
18. Role of Bisphosphonates in Skeletal Metastases......Page 305
19. Radiation Treatment of Bone Metastases......Page 322
back-matter.pdf......Page 336
