Bone and Cancer is the fifth volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson. This title features current knowledge on mechanisms of metastasis, the role of the bone microenvironment in cancer progression, how inflammatory cytokines function in metastasis and osteolysis, and the role of osteoblasts, thus bringing to the clinician and researcher cellular and molecular findings that affect the search for drugs and lead to translational studies.
Each chapter contains an extensive bibliography that permits readers to learn more about specific aspects of the chapter topic. Tables, diagrams and figures illustrate and clarify cellular events that lead to development and progression of cancer in bone. Insights based on cellular and molecular events clarify the clinical picture and may lead to translational research and focused therapy. The chapters, authored by authorities from throughout the world, emphasize how current knowledge can lead to better treatement.
Other titles in this series:-
Bone Formation
Bone Resorption
Engineering of Functional Skeletal Tissues
Bone and Osteoarthritis
Author(s): Aaron M. Havens, Yusuke Shiozawa, Russell S. Taichman (auth.), Felix Bronner, Mary C. Farach-Carson (eds.)
Series: Topics in Bone Biology 5
Edition: 1
Publisher: Springer-Verlag London
Year: 2009
Language: English
Pages: 246
Tags: Oncology; Orthopedics; Cancer Research
Front Matter....Pages i-xviii
Blood–Bone Axis and Bone Marrow Microenvironment....Pages 1-17
Genetics of Osteosarcoma....Pages 19-42
Multiple Myeloma and Other Hematological Malignancies of Bone....Pages 43-56
Mechanism of Metastasis to Bone: The Role of Bone Marrow Endothelium....Pages 57-71
Lysophosphatidic Acid: Role in Bone and Bone Cancer....Pages 73-88
Role of Bone Microenvironment/Metastatic Niche in Cancer Progression....Pages 89-101
Detection and Characterization of Disseminated Tumor Cells present in Bone Marrow of Cancer Patients....Pages 103-117
Molecular Imaging of Cancer Cells Growing in Bone....Pages 119-140
Inflammatory Cytokines and Their Role in Bone Metastasis and Osteolysis....Pages 141-155
Prostate Cancer Bone Colonization: Osteomimicry in the Bone Niche....Pages 157-166
Bone Pain Associated with Cancer Metastasis....Pages 167-179
Small Animal Models for the Study of Cancer in Bone....Pages 181-203
Hormonal therapies in Breast and Prostate Cancer: Effects on Bone and the Role of Bisphosphonates....Pages 205-218
Therapeutic Approaches to Metastatic Bone Cancer II: Targeted and Non-targeted Systemic Agents....Pages 219-227
The Role of Allogeneic Bone Marrow Transplant in Cancer Treatment....Pages 229-239
The Role of Radiosurgery in the Treatment of Bone Localized Cancers....Pages 241-251
Back Matter....Pages 1-12
