The BLyS/BAFF family of cytokines and receptors has captured and held the attention of B cell biologists during the last decade. Discovery of the two ligands and three receptors comprising this family has yielded a watershed of insights; fostering fresh paradigms in our views about the differentiation, selection, and homeostatic control of virtually all B cell subsets. Moreover, because these processes are intimately tied to the mechanistic underpinnings of immune tolerance and activation, increased understanding of these activities promises translational progress in autoimmunity, neoplasia, and transplantation.
Author(s): Pascal Schneider (auth.), Michael P. Cancro (eds.)
Series: Contemporary Immunology
Edition: 1
Publisher: Humana Press
Year: 2010
Language: English
Pages: 284
Tags: Immunology; Microbiology
Front Matter....Pages i-xiii
The Beautiful Structures of BAFF, APRIL, and Their Receptors....Pages 1-18
BAFF Receptor Regulation of Peripheral B-Lymphocyte Survival and Development....Pages 19-41
Regulation of B-Cell Self-Tolerance By BAFF and the Molecular Basis of Its Action....Pages 43-63
Role of BAFF and APRIL in Antibody Production and Diversification....Pages 65-92
Signal Transduction by Receptors for BAFF and APRIL....Pages 93-114
TACI Signaling and Its Role in Immunity....Pages 115-124
The BAFF/APRIL System in Autoimmunity....Pages 125-160
Systemic Immune-Based Rheumatic Diseases: Blissless States of BLySfulness....Pages 161-193
The Role of BAFF and APRIL in Regulating Human B-Cell Behaviour: Implications for Disease Pathogenesis....Pages 195-220
Translation of BAFF Inhibition from Mouse to Non-human Primate and Human....Pages 221-243
BLyS/BR3 Receptor Signaling in the Biology and Pathophysiology of Aggressive B-Cell Lymphomas....Pages 245-263
Tipping the Scales of Survival: The Role of BLyS in B-Cell Malignancies....Pages 265-282
Back Matter....Pages 283-289
