This handbook provides a comprehensive account of materials science approaches to characterization of biominerals and biomimetic model systems. It covers state-of-the-art in the characterization of atomic and molecular structure, including the latest in diffraction, scattering, and spectroscopy, in addition to methods for imaging morphology and interfaces. It also looks at computational approaches and probes for examining energetics and forces in assembly. The final section focuses on mechanical function and measurement methodology as well as studies of live cells and whole organ.