Recent developments in stem cell biology have opened new directions in cell therapy. This book provides the state-of-the-art developments in using biomaterials as artificial niches for engineering stem cells, both for the purpose of better understanding their biology under 3D biomimetic conditions as well as for developing new strategies for efficient long term maintenance and directed differentiation of stem cells into various therapeutic lineages. Animal and human stem cells of both embryonic and adult origin are discussed with applications ranging from nerve regeneration, orthopedics, cardiovascular therapy, blood cell generation and cancer therapy. Both synthetic and natural biomaterials are reviewed with emphasis on how material-stem cell interactions direct specific signaling pathways and ultimately modulate the cell fate. This book is valuable for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells.
Author(s): Sarah E. Stabenfeldt, Ashley Carson Brown (auth.), Krishnendu Roy (eds.)
Series: Studies in Mechanobiology, Tissue Engineering and Biomaterials 2
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2010
Language: English
Pages: 309
Tags: Biomedical Engineering; Stem Cells; Biomaterials; Human Genetics; Medical Biochemistry
Front Matter....Pages i-viii
Engineering ECM Complexity into Biomaterials for Directing Cell Fate....Pages 1-18
Functional Biomaterials for Controlling Stem Cell Differentiation....Pages 19-44
Integration of Biomaterials into 3D Stem Cell Microenvironments....Pages 45-59
Stem Cell Interaction with Topography....Pages 61-87
The Nanofiber Matrix as an Artificial Stem Cell Niche....Pages 89-118
Micropatterned Hydrogels for Stem Cell Culture....Pages 119-152
Microengineering Approach for Directing Embryonic Stem Cell Differentiation....Pages 153-171
Biomaterials as Stem Cell Niche: Cardiovascular Stem Cells....Pages 173-193
The Integrated Role of Biomaterials and Stem Cells in Vascular Regeneration....Pages 195-223
Synthetic Niches for Stem Cell Differentiation into T cells....Pages 225-245
Understanding Hypoxic Environments: Biomaterials Approaches to Neural Stabilization and Regeneration after Ischemia....Pages 247-274
Biomaterial Applications in the Adult Skeletal Muscle Satellite Cell Niche: Deliberate Control of Muscle Stem Cells and Muscle Regeneration in the Aged Niche....Pages 275-308
Back Matter....Pages 309-309
